Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q6FA43 (SAHH_ACIAD) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenosylhomocysteinase
EC=3.3.1.1
Alternative name(s):
S-adenosyl-L-homocysteine hydrolase
Short name=AdoHcyase
Gene names
Name:ahcY
Ordered Locus Names:ACIAD2282
OrganismAcinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]
Taxonomic identifier62977 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length467 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine By similarity. HAMAP MF_00563

Catalytic activity

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. HAMAP MF_00563

Cofactor

Binds 1 NAD per subunit By similarity. HAMAP MF_00563

Pathway

Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. HAMAP MF_00563

Subcellular location

Cytoplasm By similarity HAMAP MF_00563.

Sequence similarities

Belongs to the adenosylhomocysteinase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processone-carbon metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionadenosylhomocysteinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 467467Adenosylhomocysteinase HAMAP MF_00563
PRO_0000116938

Regions

Nucleotide binding170 – 1723NAD By similarity
Nucleotide binding233 – 2386NAD By similarity
Nucleotide binding326 – 3283NAD By similarity

Sites

Binding site681Substrate By similarity
Binding site1441Substrate By similarity
Binding site1691Substrate By similarity
Binding site1991Substrate By similarity
Binding site2031Substrate By similarity
Binding site2041NAD By similarity
Binding site2561NAD By similarity
Binding site3051NAD By similarity
Binding site3731NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6FA43 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: F01509306CD0DF6A

FASTA46751,370
        10         20         30         40         50         60 
MFFKEIVMNA VNASFTDYKV ADISLADYGR KEIKLAEAEM PALIGLRKRY AAEKPLAGAK 

        70         80         90        100        110        120 
ILGCIHMTIQ TAVLIETLVE LGAEVRWTSC NIFSTQDHAA AAIAASGVPV FAWKGETEEE 

       130        140        150        160        170        180 
YNWCLEQQIN VNGKPWDANM ILDDGGDLTA LVHEKYPTLL DHIHGITEET TTGVQRLLEM 

       190        200        210        220        230        240 
WKDGSLKVPA INVNDSVTKS KNDNKYGCRH SLNDAIKRAT DMLLSGRRAL VIGYGDVGKG 

       250        260        270        280        290        300 
SAQSLRQEGM IVRVTEVDPI CAMQACMDGY EVVSPYKNGV QTGKKEDINL DLLKNTDLIV 

       310        320        330        340        350        360 
TTTGNYHVCD SAMLDTLKAG AVVCNIGHFD TEIDTNYLRG YKWVEVKPQV HQVYRSENEN 

       370        380        390        400        410        420 
DYLILLSEGR LVNLGNATGH PSRVMDGSFA NQVLGQIHLF QEKFADLPAS EKAAQIRVEV 

       430        440        450        460 
LPKKLDEEVA AAMVLGFGGV LTQLTSVQAD YLGVPVEGPF KSDAYKY

« Hide

References

[1]"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium."
Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C.
Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ADP1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR543861 Genomic DNA. Translation: CAG69070.1.
RefSeqYP_046892.1. NC_005966.1.

3D structure databases

ProteinModelPortalQ6FA43.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6FA43.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2879932.
GenomeReviewsGene locus ACIAD2282 in contig CR543861_GR.
KEGGaci:ACIAD2282.
NMPDRfig|62977.3.peg.2179.
PATRIC20742218. VBIAciSp98416_2051.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0499.
HOGENOMHBG352029.
OMASAQVWVT.
PhylomeDBQ6FA43.
ProtClustDBPRK05476.

Enzyme and pathway databases

BioCycASP62977:ACIAD2282-MONOMER.

Family and domain databases

HAMAPMF_00563. AdoHcyase.
[Tree]
InterProIPR000043. Adenosylhomocysteinase.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
[Graphical view]
KOK01251.
PANTHERPTHR23420. Ad_hcy_hydrolase. 1 hit.
PfamPF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
[Graphical view]
PIRSFPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTSM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
[Graphical view]
TIGRFAMsTIGR00936. AhcY. 1 hit.
PROSITEPS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSAHH_ACIAD
AccessionPrimary (citable) accession number: Q6FA43
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 19, 2004
Last modified: January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents