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Q6FA07

- LPXB_ACIAD

UniProt

Q6FA07 - LPXB_ACIAD

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Protein

Lipid-A-disaccharide synthase

Gene
lpxB, ACIAD2324
Organism
Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciASP62977:GJVV-2180-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:ACIAD2324
OrganismiAcinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Taxonomic identifieri62977 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter
ProteomesiUP000000430: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Lipid-A-disaccharide synthaseUniRule annotationPRO_0000255157Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi62977.ACIAD2324.

Structurei

3D structure databases

ProteinModelPortaliQ6FA07.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6FA07-1 [UniParc]FASTAAdd to Basket

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MYGTCHLSTH KLKIGIVVGE VSGDTLGVQL MRSFREQGID AEFEGIGGPQ    50
MIAEGFNSFY PMETLSVMGI VEVLKDIKKL FAVRDGLVQR WREHPVDVFV 100
GIDAPDFNLR LSKSLKEKNL PIRTVQYVSP SVWAWRQGRV KGIKATIDLV 150
LCLFPFEKNF YEQHSVRAAF VGHPLAKLLP LNNSLVEAKQ ALGLNPEKTY 200
IALLPGSRKG EVERLLPMLL GSAEILLKKY PDVEYLIPAI SDVRKKQIQD 250
GIQSIAPQYA QKLHVLENQD QESKIGRQVM NASDIVALAS GTATLEAMLL 300
HRPMVSFYKL NTLTYIIAKL LVKIQYYSLP NIIAGKKVIE ELIQKDANPE 350
RLAHEIEKLM NNETAKIQMM QHFSMHKQLI SGNTEDPVQA IMTLIQ 396
Length:396
Mass (Da):44,513
Last modified:July 19, 2004 - v1
Checksum:i38F11C98CA97A24E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR543861 Genomic DNA. Translation: CAG69106.1.
RefSeqiWP_011182487.1. NC_005966.1.
YP_046928.1. NC_005966.1.

Genome annotation databases

EnsemblBacteriaiCAG69106; CAG69106; ACIAD2324.
GeneIDi2879759.
KEGGiaci:ACIAD2324.
PATRICi20742294. VBIAciSp98416_2089.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR543861 Genomic DNA. Translation: CAG69106.1 .
RefSeqi WP_011182487.1. NC_005966.1.
YP_046928.1. NC_005966.1.

3D structure databases

ProteinModelPortali Q6FA07.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 62977.ACIAD2324.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG69106 ; CAG69106 ; ACIAD2324 .
GeneIDi 2879759.
KEGGi aci:ACIAD2324.
PATRICi 20742294. VBIAciSp98416_2089.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci ASP62977:GJVV-2180-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium."
    Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C.
    Nucleic Acids Res. 32:5766-5779(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33305 / BD413 / ADP1.

Entry informationi

Entry nameiLPXB_ACIAD
AccessioniPrimary (citable) accession number: Q6FA07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 19, 2004
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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