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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi368 – 375ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:ACIAD2365
OrganismiAcinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Taxonomic identifieri62977 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter
Proteomesi
  • UP000000430 Componenti: Chromosome

Subcellular locationi

Q6F9X0:
  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei60 – 80HelicalUniRule annotationAdd BLAST21
Transmembranei156 – 176HelicalUniRule annotationAdd BLAST21
Transmembranei244 – 264HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000925671 – 574Lipid A export ATP-binding/permease protein MsbAAdd BLAST574

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi62977.ACIAD2365.

Structurei

3D structure databases

ProteinModelPortaliQ6F9X0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 304ABC transmembrane type-1UniRule annotationAdd BLAST283
Domaini335 – 570ABC transporterUniRule annotationAdd BLAST236

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK11085.
OMAiSPLMEFL.
OrthoDBiPOG091H00DB.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6F9X0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQDFKVYVR LLSYLKPYWG IALLVLVGFG INAATEVSVA KLLKYIIDAI
60 70 80 90 100
QEGSRADLDW FPLLIVLLVF FRGLGLFMGG YYTAVISRRL IFSIRQEIYA
110 120 130 140 150
KLIRLPSQYY LDNSSGHISA KIMYNVEQLT AASSESLKIM VKDGLITLGL
160 170 180 190 200
LGYLLYTNWR LTLCIFIFMP IIGVLVRKAS KRMRKLSIQV QNTMGDVNHV
210 220 230 240 250
VQESIGGQAV VKSFVGEEFE QKRFYKSSED NLKRGLKMVI VQNLNSPLVQ
260 270 280 290 300
LVMAMAMSLI VWLALRPQIL GETTAGEFVA YITAAGLLAK PIKNLTDVNE
310 320 330 340 350
KLQRGIAAAY SVFELLDLPS EENHGTQTPK LQGDVRFDHV TLEYAGQVKA
360 370 380 390 400
IKDFNLTIEP GETVAIVGRS GAGKTSLVNL LVRFQEVTSG SLYLDHIPIQ
410 420 430 440 450
DIELSCLRQQ VAMVNQQVVL FNRSVRENIA YGQLEGAAEA DIVAAAKAAY
460 470 480 490 500
AHDFIMNLPQ GYDTILGAQG LNLSGGQRQR IAIARAILKN APILILDEAT
510 520 530 540 550
SALDNESEHF IQKAFDEAMQ NRTTIVIAHR LSTIENADRI VVMDKGQIIE
560 570
QGTHQELLLK QGAYFQLHQR NFEE
Length:574
Mass (Da):64,005
Last modified:July 19, 2004 - v1
Checksum:i27AADAE78AB5EF39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR543861 Genomic DNA. Translation: CAG69143.1.
RefSeqiWP_004928194.1. NC_005966.1.

Genome annotation databases

EnsemblBacteriaiCAG69143; CAG69143; ACIAD2365.
KEGGiaci:ACIAD2365.

Similar proteinsi

Entry informationi

Entry nameiMSBA_ACIAD
AccessioniPrimary (citable) accession number: Q6F9X0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 19, 2004
Last modified: October 25, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families