Reviewed, UniProtKB/Swiss-Prot Q6F9J1 (PQQC_ACIAD)

Names and origin

Protein names

Recommended name:
    Pyrroloquinoline-quinone synthase
    EC=1.3.3.11
Alternative name(s):
    Coenzyme PQQ synthesis protein C
    Pyrroloquinoline quinone biosynthesis protein C

Gene names

Name:	pqqC
Ordered Locus Names:	ACIAD2505

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

62977 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ By similarity. HAMAP MF_00654
Catalytic activity	6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O. HAMAP MF_00654
Pathway	Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis. HAMAP MF_00654
Sequence similarities	Belongs to the pqqC family.

Ontologies

Keywords
Biological process	PQQ biosynthesis
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pyrroloquinoline quinone biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	pyrroloquinoline-quinone synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	Pyrroloquinoline-quinone synthase HAMAP MF_00654		PRO_0000219975

Sequences

	Sequence		Length	Mass (Da)
	Q6F9J1-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: B7EA183D0DF7A76A	FASTA	255	29,662
	10 20 30 40 50 60 MRFNMTTTLF SPAEFEQALR DKGRYYHIHH PYHIMMNDGH ATKQQIQGWV ANRFYYQVNI 70 80 90 100 110 120 PLKDAAIMAN CPDPATRRKW VQRILDHDGQ HDDHGGIEAW LRLGEAVGLD RETILSQKMV 130 140 150 160 170 180 LPSVRFAVDA YVNFARRACW QEAACSSLTE LFAPAIHQSR LDTWPTHYPW IDAEGYAYFR 190 200 210 220 230 240 GRLSQANRDV EHGLELALEY CNTVDRQQRM LNILQFKLDI LWTILDGMSM AYVLERAPYH 250 TVTQEAVWHQ KGLLG

References

[1]

"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR543861 Genomic DNA. Translation: CAG69273.1.
RefSeq	YP_047095.1.
3D structure databases
SMR	Q6F9J1. Positions 5-254.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6F9J1.
Genome annotation databases
GeneID	2879637.
GenomeReviews	Gene locus ACIAD2505 in contig CR543861_GR.
KEGG	aci:ACIAD2505.
NMPDR	fig|62977.3.peg.2104.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG5424.
HOGENOM	HBG288944.
OMA	DSWPQHY.
Enzyme and pathway databases
BioCyc	ASP62977:ACIAD2505-MONOMER.
Family and domain databases
HAMAP	MF_00654. PQQ_syn_PqqC. [Tree]
InterPro	IPR016084. Haem_Oase-like_multi-hlx. IPR011845. PQQ_synth_PqqC. IPR004305. TENA/THI4/PQQ_synth_PqqC. [Graphical view]
Gene3D	G3DSA:1.20.910.10. Haem_Oase-like_multi-hlx. 1 hit.
Pfam	PF03070. TENA_THI-4. 1 hit. [Graphical view]
TIGRFAMs	TIGR02111. PQQ_syn_pqqC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PQQC_ACIAD

Accession

Primary (citable) accession number: Q6F9J1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	July 19, 2004
Last modified:	February 9, 2010
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)