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Protein

Thymidylate kinase

Gene

tmk

Organism
Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 14ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processNucleotide biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciASP62977:G1GJ8-2371-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinaseUniRule annotation
Gene namesi
Name:tmkUniRule annotation
Ordered Locus Names:ACIAD2588
OrganismiAcinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Taxonomic identifieri62977 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter
Proteomesi
  • UP000000430 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001552271 – 202Thymidylate kinaseAdd BLAST202

Proteomic databases

PRIDEiQ6F9B5

Interactioni

Protein-protein interaction databases

STRINGi62977.ACIAD2588

Structurei

3D structure databases

ProteinModelPortaliQ6F9B5
SMRiQ6F9B5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZMD Bacteria
COG0125 LUCA
HOGENOMiHOG000229078
KOiK00943
OMAiFLYTADH
OrthoDBiPOG091H02B9

Family and domain databases

HAMAPiMF_00165 Thymidylate_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR018094 Thymidylate_kinase
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00041 DTMP_kinase, 1 hit

Sequencei

Sequence statusi: Complete.

Q6F9B5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFISFEGTEG VGKTTLIRKL YEHFEASGKQ VVLTREPGGT PLAEQIRSLL
60 70 80 90 100
LAVNHDEPMS SDTELLLMYA ARAQHLQQVI VPALADEKLV LSDRFTDASY
110 120 130 140 150
AYQCVGRGLS KDKLNTLNQT FVSHMPDITF WLDAPIELGM SRARERGALD
160 170 180 190 200
RFEQEKVEFF QRVRQGYQQL HELYPERIKR LDATQAPEIV FQEALEHIQA

LV
Length:202
Mass (Da):23,049
Last modified:July 19, 2004 - v1
Checksum:iF78488DB63AFC6A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR543861 Genomic DNA Translation: CAG69350.1
RefSeqiWP_004928742.1, NC_005966.1

Genome annotation databases

EnsemblBacteriaiCAG69350; CAG69350; ACIAD2588
KEGGiaci:ACIAD2588

Similar proteinsi

Entry informationi

Entry nameiKTHY_ACIAD
AccessioniPrimary (citable) accession number: Q6F9B5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: July 19, 2004
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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