Q6F973 (PUR5_ACIAD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase
EC=6.3.3.1

Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase

Gene names

Name:	purM
Ordered Locus Names:	ACIAD2634

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

62977 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP MF_00741_B
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP MF_00741_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00741_B.
Sequence similarities	Belongs to the AIR synthase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 356	356	Phosphoribosylformylglycinamidine cyclo-ligase HAMAP MF_00741_B		PRO_0000258324

Sequences

	Sequence		Length	Mass (Da)
	Q6F973 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: F4309330D84DD540	FASTA	356	37,697
	10 20 30 40 50 60 MSNSTSTPNT GLSYKDAGVD IEAGDALVDR IKSVAKRTTR PEVMGGLGGF GALCKIPKGY 70 80 90 100 110 120 EEPVLVSGTD GVGTKLRLAL NLNRHDTIGQ DLVAMCVNDL LVCGAEPLFF LDYYATGHLN 130 140 150 160 170 180 VDVAANVVTG IGKGCELAGC ALVGGETAEM PGMYEGEDYD LAGFAVGVVE QSKIIDGSKV 190 200 210 220 230 240 KAGDVLIGVA SSGAHSNGYS LLRKILDVKN VDLTQEIDGR SLADAAMEPT RIYVKPVLEL 250 260 270 280 290 300 CKQVDVHAMA HITGGGLPGN LPRVLPNGAQ AVIDEASWEW PELFKLLQRE GGVEQFEMYR 310 320 330 340 350 TFNCGVGMVI AVDAADADKT IQVLNAQGEK SWKIGHIQDN AESIEGADEK IRVIFA

References

[1]

"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ADP1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR543861 Genomic DNA. Translation: CAG69392.1.
RefSeq	YP_047214.1. NC_005966.1.
3D structure databases
HSSP	HSSP built from PDB template 1CLI based on UniProtKB P08178.
ProteinModelPortal	Q6F973.
SMR	Q6F973. Positions 10-338.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6F973.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2880908.
GenomeReviews	Gene locus ACIAD2634 in contig CR543861_GR.
KEGG	aci:ACIAD2634.
NMPDR	fig|62977.3.peg.2407.
PATRIC	20742869. VBIAciSp98416_2375.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0150.
HOGENOM	HBG531222.
OMA	GIDMIAM.
PhylomeDB	Q6F973.
ProtClustDB	PRK05385.
Enzyme and pathway databases
BioCyc	ASP62977:ACIAD2634-MONOMER.
Family and domain databases
HAMAP	MF_00741_B. AIRS_B. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view]
KO	K01933.
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR00878. PurM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR5_ACIAD

Accession

Primary (citable) accession number: Q6F973

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	July 19, 2004
Last modified:	January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program