Q6F943 (PDXB_ACIAD) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 69.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Erythronate-4-phosphate dehydrogenase EC=1.1.1.290 | ||||
| Gene names |
| ||||
| Organism | Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 62977 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter![]() |
Protein attributes
| Sequence length | 355 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate By similarity. HAMAP-Rule MF_01825 |
| Catalytic activity | 4-phospho-D-erythronate + NAD+ = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + NADH. HAMAP-Rule MF_01825 |
| Pathway | Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 2/5. HAMAP-Rule MF_01825 |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | Cytoplasm Potential HAMAP-Rule MF_01825. |
| Sequence similarities | Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Pyridoxine biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological_process | pyridoxine biosynthetic process Inferred from electronic annotation. Source: HAMAP |
| Cellular_component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | 4-phosphoerythronate dehydrogenase activity Inferred from electronic annotation. Source: EC NAD bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 355 | 355 | Erythronate-4-phosphate dehydrogenase HAMAP-Rule MF_01825 | PRO_0000297429 | |||||
Sites | |||||||||
| Active site | 206 | 1 | By similarity | ||||||
| Active site | 234 | 1 | By similarity | ||||||
| Active site | 251 | 1 | Proton donor By similarity | ||||||
| Binding site | 45 | 1 | Substrate By similarity | ||||||
| Binding site | 66 | 1 | Substrate By similarity | ||||||
| Binding site | 146 | 1 | NAD By similarity | ||||||
| Binding site | 229 | 1 | NAD By similarity | ||||||
| Binding site | 254 | 1 | NAD; via amide nitrogen By similarity | ||||||
| Binding site | 255 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ADP1. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CR543861 Genomic DNA. Translation: CAG69422.1. |
| RefSeq | YP_047244.1. NC_005966.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1SC6 based on UniProtKB P0A9T0. |
| ProteinModelPortal | Q6F943. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 62977.ACIAD2667. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | CAG69422; CAG69422; ACIAD2667. |
| GeneID | 2878298. |
| KEGG | aci:ACIAD2667. |
| PATRIC | 20742933. VBIAciSp98416_2407. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0111. |
| HOGENOM | HOG000234432. |
| KO | K03473. |
| OMA | SSAPGCN. |
| ProtClustDB | CLSK707643. |
Enzyme and pathway databases | |
| BioCyc | ASP62977:GJVV-2481-MONOMER. |
| UniPathway | UPA00244; UER00310. |
Family and domain databases | |
| Gene3D | 3.40.50.720. 2 hits. |
| HAMAP | MF_01825. PdxB. |
| InterPro | IPR006139. D-isomer_2_OHA_DH_cat_dom. IPR006140. D-isomer_2_OHA_DH_NAD-bd. IPR020921. Erythronate-4-P_DHase. IPR024531. Erythronate-4-P_DHase_dimer. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| PANTHER | PTHR10996:SF4. PTHR10996:SF4. 1 hit. |
| Pfam | PF00389. 2-Hacid_dh. 1 hit. PF02826. 2-Hacid_dh_C. 1 hit. PF11890. DUF3410. 1 hit. [Graphical view] |
| PROSITE | PS00065. D_2_HYDROXYACID_DH_1. 1 hit. PS00670. D_2_HYDROXYACID_DH_2. False negative. PS00671. D_2_HYDROXYACID_DH_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PDXB_ACIAD | ||||||||
| Accession | Primary (citable) accession number: Q6F943 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with
