Reviewed, UniProtKB/Swiss-Prot Q6F821 (ILVC_ACIAD)

Names and origin

Protein names

Recommended name:
    Ketol-acid reductoisomerase
    EC=1.1.1.86
Alternative name(s):
    Acetohydroxy-acid isomeroreductase
    Alpha-keto-beta-hydroxylacil reductoisomerase

Gene names

Name:	ilvC
Ordered Locus Names:	ACIAD3102

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

62977 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.
Pathway	Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.
Sequence similarities	Belongs to the ketol-acid reductoisomerase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	isoleucine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW valine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	binding Inferred from electronic annotation. Source: InterPro ketol-acid reductoisomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	Ketol-acid reductoisomerase		PRO_0000226153
Sites
	Active site	107	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6F821-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 1564789A03851645	FASTA	338	36,943
	10 20 30 40 50 60 MQIFYDKDCD LSIIQGKKVA IIGYGSQGHA HALNLKDSGV DVTVGLRANS ASWKKAENAG 70 80 90 100 110 120 LKVAEVPEAV KQADLVMILT PDEFQSQLYR DVIEPNIKEG ATLAFAHGFS VLYNQVVPRQ 130 140 150 160 170 180 DLDVIMVAPK APGHTVRSEF QRGSGVPDLI AIHQDASGNA RNVALSYASG VGGGRTGIIE 190 200 210 220 230 240 TSFREETETD LFGEQAVLCG GAVELVKMGF ETLVEAGYSP EMAYFECLHE LKLIVDLMFE 250 260 270 280 290 300 GGIADMNYSV SNNAEYGEYV TGVEVINEQS REAMRNALKR IQSGEYAKMF IQEGALNYPS 310 320 330 MTARRRQNAA HGIEVTGSKL RAMMPWIQAN KIVDKEKN

References

[1]

"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR543861 Genomic DNA. Translation: CAG69794.1.
RefSeq	YP_047616.1.
3D structure databases
SMR	Q6F821. Positions 1-327.
ModBase	Search...
Genome annotation databases
GeneID	2877810.
GenomeReviews	Gene locus ACIAD3102 in contig CR543861_GR.
KEGG	aci:ACIAD3102.
NMPDR	fig|62977.3.peg.2809.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6F821.
Enzyme and pathway databases
BioCyc	ASP62977:ACIAD3102-MON.
Family and domain databases
HAMAP	MF_00435. [Tree]
InterPro	IPR013023. AcH_isomrdctse. IPR000506. AcH_isomrdctse_C. IPR013116. IlvN. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR21371. AcH_isomrdctse. 1 hit.
Pfam	PF01450. IlvC. 1 hit. PF07991. IlvN. 1 hit. [Graphical view]
TIGRFAMs	TIGR00465. ilvC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ILVC_ACIAD

Accession

Primary (citable) accession number: Q6F821

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	July 19, 2004
Last modified:	November 25, 2008
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)