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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei639 – 6391ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciASP62977:GJVV-2875-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:ACIAD3106
OrganismiAcinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Taxonomic identifieri62977 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter
ProteomesiUP000000430 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 873873Leucine--tRNA ligasePRO_0000151959Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi62977.ACIAD3106.

Structurei

3D structure databases

ProteinModelPortaliQ6F817.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi47 – 5711"HIGH" regionAdd
BLAST
Motifi636 – 6405"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6F817-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTAHIDAEY QANAIESQIQ NDWENRKAFK VADTVEGKHR YILSMFPYPS
60 70 80 90 100
GKLHMGHVRN YTIGDVISRF YRLKGETVLQ PMGWDAFGLP AENAAIAHQV
110 120 130 140 150
APAKWTFENI AYMRDQLKKL GLSIDWDREF ATCTPEYYHW EQWLFVQLYK
160 170 180 190 200
KGLIYRKLST VNWDPVDQTV LANEQVENGR GWRSGALVEK RDIPMYYFRI
210 220 230 240 250
TDYAQELLDD LDTLKDGWPQ QVLTMQRNWI GRSTGMDITF PSANPEIYAD
260 270 280 290 300
GLTVYTTRAD TLMGVTYVAV AAEHPMALKA AENNPELAAF IEECRMGSVA
310 320 330 340 350
EADLATAEKK GMATGLFVKH PVTGEEVPVW IANYVLMSYG SGAVMAVPAH
360 370 380 390 400
DERDFEFANK FNLPIKQVID AKAADDAEYS VTAWQEWYGS KEGTLVNSGE
410 420 430 440 450
FDGLEFQAAF DAFLAKLEPQ GLANSKVQFR LRDWGVSRQR YWGCPIPMIN
460 470 480 490 500
CDSCGQVPVP EEQLPVVLPT DVVPDGSGNP LNKMPEFYET TCPSCGGHAR
510 520 530 540 550
RETDTLDTFV ESSWYYARYA SPDFTGGMVK PEAAQSWLPV NQYIGGVEHA
560 570 580 590 600
ILHLLYARFF HKLMRDEGVV QGNEPFTNLL TQGMVLADTF YRESESGKKT
610 620 630 640 650
WFNPADIILE RDEKGRIVSA KYSGDGQDVV IGGQEKMSKS KNNGIDPQAI
660 670 680 690 700
IDQYGADTAR VFMMFAAPPD QSLEWSDAGV EGANRFLKRV WRLATGFLEK
710 720 730 740 750
GYAQAPIAAE LSKDAQDLRR KTHETIQKVG DDIERRHAFN TAIAALMELL
760 770 780 790 800
NATSKFEVQT ADDAAVAREA IETLLTLLAP FAPHLSQTLL AEFGIDLIAA
810 820 830 840 850
QFPSVDESAL TRNTQTIVVQ VNGKLRGKLE VSVEISKDEL LAQAKALPEI
860 870
QQFLTGPTKK EIVVPNKLVN LVV
Length:873
Mass (Da):97,658
Last modified:July 19, 2004 - v1
Checksum:i11032A965B307CED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR543861 Genomic DNA. Translation: CAG69798.1.
RefSeqiWP_004924404.1. NC_005966.1.
YP_047620.1. NC_005966.1.

Genome annotation databases

EnsemblBacteriaiCAG69798; CAG69798; ACIAD3106.
KEGGiaci:ACIAD3106.
PATRICi20743697. VBIAciSp98416_2772.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR543861 Genomic DNA. Translation: CAG69798.1.
RefSeqiWP_004924404.1. NC_005966.1.
YP_047620.1. NC_005966.1.

3D structure databases

ProteinModelPortaliQ6F817.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi62977.ACIAD3106.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG69798; CAG69798; ACIAD3106.
KEGGiaci:ACIAD3106.
PATRICi20743697. VBIAciSp98416_2772.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciASP62977:GJVV-2875-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium."
    Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C.
    Nucleic Acids Res. 32:5766-5779(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33305 / BD413 / ADP1.

Entry informationi

Entry nameiSYL_ACIAD
AccessioniPrimary (citable) accession number: Q6F817
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 19, 2004
Last modified: May 27, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.