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Q6F817 (SYL_ACIAD) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:ACIAD3106
OrganismAcinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) [Complete proteome] [HAMAP]
Taxonomic identifier62977 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter

Protein attributes

Sequence length873 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 873873Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000151959

Regions

Motif47 – 5711"HIGH" region HAMAP-Rule MF_00049
Motif636 – 6405"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6391ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6F817 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 11032A965B307CED

FASTA87397,658
        10         20         30         40         50         60 
MTTAHIDAEY QANAIESQIQ NDWENRKAFK VADTVEGKHR YILSMFPYPS GKLHMGHVRN 

        70         80         90        100        110        120 
YTIGDVISRF YRLKGETVLQ PMGWDAFGLP AENAAIAHQV APAKWTFENI AYMRDQLKKL 

       130        140        150        160        170        180 
GLSIDWDREF ATCTPEYYHW EQWLFVQLYK KGLIYRKLST VNWDPVDQTV LANEQVENGR 

       190        200        210        220        230        240 
GWRSGALVEK RDIPMYYFRI TDYAQELLDD LDTLKDGWPQ QVLTMQRNWI GRSTGMDITF 

       250        260        270        280        290        300 
PSANPEIYAD GLTVYTTRAD TLMGVTYVAV AAEHPMALKA AENNPELAAF IEECRMGSVA 

       310        320        330        340        350        360 
EADLATAEKK GMATGLFVKH PVTGEEVPVW IANYVLMSYG SGAVMAVPAH DERDFEFANK 

       370        380        390        400        410        420 
FNLPIKQVID AKAADDAEYS VTAWQEWYGS KEGTLVNSGE FDGLEFQAAF DAFLAKLEPQ 

       430        440        450        460        470        480 
GLANSKVQFR LRDWGVSRQR YWGCPIPMIN CDSCGQVPVP EEQLPVVLPT DVVPDGSGNP 

       490        500        510        520        530        540 
LNKMPEFYET TCPSCGGHAR RETDTLDTFV ESSWYYARYA SPDFTGGMVK PEAAQSWLPV 

       550        560        570        580        590        600 
NQYIGGVEHA ILHLLYARFF HKLMRDEGVV QGNEPFTNLL TQGMVLADTF YRESESGKKT 

       610        620        630        640        650        660 
WFNPADIILE RDEKGRIVSA KYSGDGQDVV IGGQEKMSKS KNNGIDPQAI IDQYGADTAR 

       670        680        690        700        710        720 
VFMMFAAPPD QSLEWSDAGV EGANRFLKRV WRLATGFLEK GYAQAPIAAE LSKDAQDLRR 

       730        740        750        760        770        780 
KTHETIQKVG DDIERRHAFN TAIAALMELL NATSKFEVQT ADDAAVAREA IETLLTLLAP 

       790        800        810        820        830        840 
FAPHLSQTLL AEFGIDLIAA QFPSVDESAL TRNTQTIVVQ VNGKLRGKLE VSVEISKDEL 

       850        860        870 
LAQAKALPEI QQFLTGPTKK EIVVPNKLVN LVV 

« Hide

References

[1]"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium."
Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C.
Nucleic Acids Res. 32:5766-5779(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33305 / BD413 / ADP1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR543861 Genomic DNA. Translation: CAG69798.1.
RefSeqYP_047620.1. NC_005966.1.

3D structure databases

ProteinModelPortalQ6F817.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING62977.ACIAD3106.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG69798; CAG69798; ACIAD3106.
GeneID2880116.
KEGGaci:ACIAD3106.
PATRIC20743697. VBIAciSp98416_2772.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAGIEHACM.
OrthoDBEOG63Z74X.
ProtClustDBPRK00390.

Enzyme and pathway databases

BioCycASP62977:GJVV-2875-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 2 hits.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_ACIAD
AccessionPrimary (citable) accession number: Q6F817
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 19, 2004
Last modified: April 16, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries