Reviewed,
UniProtKB/Swiss-Prot Q6F7X1 (MDH_ACIAD)
Last modified
November 25, 2008.
Version 35.
History...
Clusters with 100%,
90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Malate dehydrogenase EC=1.1.1.37 | ||||
| Gene names |
| ||||
| Organism | Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 62977 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter |
Protein attributes
| Sequence length | 328 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. |
| Catalytic activity | (S)-malate + NAD(+) = oxaloacetate + NADH. |
| Subunit structure | Homodimer By similarity. |
| Sequence similarities | Belongs to the LDH/MDH superfamily. MDH type 2 family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Tricarboxylic acid cycle |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | glycolysis Inferred from electronic annotation. Source: InterPro malate metabolic processInferred from electronic annotation. Source: InterPro oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycleInferred from electronic annotation. Source: HAMAP |
| Molecular function | L-malate dehydrogenase activity Inferred from electronic annotation. Source: HAMAP bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 328 | 328 | Malate dehydrogenase | PRO_0000113343 | |||||
Regions | |||||||||
| Nucleotide binding | 11 – 17 | 7 | NAD By similarity | ||||||
| Nucleotide binding | 131 – 133 | 3 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 189 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 94 | 1 | Substrate By similarity | ||||||
| Binding site | 100 | 1 | Substrate By similarity | ||||||
| Binding site | 107 | 1 | NAD By similarity | ||||||
| Binding site | 114 | 1 | NAD By similarity | ||||||
| Binding site | 133 | 1 | Substrate By similarity | ||||||
| Binding site | 164 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| CR543861 Genomic DNA. Translation: CAG69844.1. | |
| RefSeq | YP_047666.1. |
3D structure databases | |
| SMR | Q6F7X1. Positions 2-327. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 2880577. |
| GenomeReviews | Gene locus ACIAD3155 in contig CR543861_GR. |
| KEGG | aci:ACIAD3155. |
| NMPDR | fig|62977.3.peg.2859. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q6F7X1. |
Enzyme and pathway databases | |
| BioCyc | ASP62977:ACIAD3155-MON. |
Family and domain databases | |
| HAMAP | MF_01517. [Tree] |
| InterPro | IPR001557. L-lactate/malate_DHase. IPR001236. Lactate/malate_DHase. IPR015955. Lactate_DHase/Glyco_Ohase_4_C. IPR001252. Malate_DHase_AS. IPR010945. Malate_DHase_SF1. IPR016040. NAD(P)-bd. [Graphical view] |
| Gene3D | G3DSA:3.90.110.10. lact_mal_DH. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| PANTHER | PTHR23382. MDH_SF1. 1 hit. |
| Pfam | PF02866. Ldh_1_C. 1 hit. PF00056. Ldh_1_N. 1 hit. [Graphical view] |
| PIRSF | PIRSF000102. Lac_mal_DH. 1 hit. |
| ProDom | PD003052. Mal_dehydrog. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR01759. MalateDH-SF1. 1 hit. |
| PROSITE | PS00068. MDH. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MDH_ACIAD | ||||||||
| Accession | Primary (citable) accession number: Q6F7X1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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