Q6F7N5 (DXS_ACIAD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-deoxy-D-xylulose-5-phosphate synthase
EC=2.2.1.7

Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Short name=DXP synthase
Short name=DXPS

Gene names

Name:	dxs
Ordered Locus Names:	ACIAD3247

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

62977 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	640 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity. HAMAP MF_00315
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: InterPro thiamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: EC thiamine pyrophosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 640	640	1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315		PRO_0000256368

Sequences

	Sequence		Length	Mass (Da)
	Q6F7N5 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: BF175C48B08484D6	FASTA	640	70,609
	10 20 30 40 50 60 MPHMLYTEIP THRPVTPLLD EIDHPQQLRQ LEQSQLTQVA DELRQFILYA AGQSGGHFGA 70 80 90 100 110 120 NLGVIELTVA LHYCFNTPHD RLIWDVGHQA YPHKVLTGRR EQLMTIRAQH GLAAFPAREE 130 140 150 160 170 180 SVFDTFGVGH SSTAISAGLG MSLARRYQQN PCEVVCIVGD GAMTAGMAFE AMNDAVAHDA 190 200 210 220 230 240 DLMVVLNDND MSISCSTGGF ARHLAAIWEK GQLVNIDEHG EAYVQPHPKW TYNSRLHQSA 250 260 270 280 290 300 TDAADNLFKA IGFDYFGPFD GHDVEHLVHV FNALKKRQGP RLIHIYTKKG KGFEPAEADP 310 320 330 340 350 360 ITYHAITKIT PVSIAPVKKS PPKYSDVFGQ WLCDEAAQDD RLLAITPAMC EGSGMVKFAK 370 380 390 400 410 420 QYPERFFDVA IAEQHAVTLA AGMACEGLKP VVAIYSTFLQ RGYDQLIHDV ALQNLDVTFG 430 440 450 460 470 480 IDRAGLVGED GPTHAGAYDY AYMRTIPNLV IMAPKDENEC RQMLHTAYDF NGPAAVRYPR 490 500 510 520 530 540 GAGLGVEIQQ ELTKLEIGKA EMVLQCHPEH DEHITILAFG SRVSVAMEAA QQLAQLHDIG 550 560 570 580 590 600 ITVVNMRFVK PLDEQIIRDL AERTQLFVTI EEHAVMAGAG SAVNEYLAKA QIMKPTLNLG 610 620 630 640 LPDTFMAQAT HTQMLKNCGL DAEGIQASIE KVWLRIVQAV

References

[1]

"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ADP1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR543861 Genomic DNA. Translation: CAG69930.1.
RefSeq	YP_047752.1. NC_005966.1.
3D structure databases
ProteinModelPortal	Q6F7N5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6F7N5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2879773.
GenomeReviews	Gene locus ACIAD3247 in contig CR543861_GR.
KEGG	aci:ACIAD3247.
NMPDR	fig|62977.3.peg.2945.
PATRIC	20743985. VBIAciSp98416_2907.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1154.
HOGENOM	HBG571647.
OMA	QYDISYM.
PhylomeDB	Q6F7N5.
ProtClustDB	PRK05444.
Enzyme and pathway databases
BioCyc	ASP62977:ACIAD3247-MONOMER.
Family and domain databases
HAMAP	MF_00315. DXP_synth. [Tree]
InterPro	IPR005477. Dxylulose-5-P_synthase. IPR011766. TPP_enzyme-bd_C. IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR020826. Transketolase_BS. IPR005476. Transketolase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KO	K01662.
Pfam	PF02775. TPP_enzyme_C. 1 hit. PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
SUPFAM	SSF52922. Transketo_C_like. 1 hit.
TIGRFAMs	TIGR00204. Dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. False negative. PS00802. TRANSKETOLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS_ACIAD

Accession

Primary (citable) accession number: Q6F7N5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	July 19, 2004
Last modified:	January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program