Reviewed, UniProtKB/Swiss-Prot Q6F7N0 (HEMH_ACIAD)

Names and origin

Protein names

Recommended name:
    Ferrochelatase
    EC=4.99.1.1
Alternative name(s):
    Protoheme ferro-lyase
    Heme synthetase

Gene names

Name:	hemH
Ordered Locus Names:	ACIAD3255

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

62977 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	340 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323
Catalytic activity	Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323
Pathway	Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323
Subcellular location	Cytoplasm By similarity HAMAP MF_00323.
Sequence similarities	Belongs to the ferrochelatase family.

Ontologies

Keywords
Biological process	Heme biosynthesis Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	heme biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ferrochelatase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 340	340	Ferrochelatase HAMAP MF_00323		PRO_0000175098
Sites
	Metal binding	202	1	Iron By similarity
	Metal binding	283	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6F7N0-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 8E49B61D7A6D3A3B	FASTA	340	38,456
	10 20 30 40 50 60 MPIFPKPKVT VILANLGTPD VPTASAVRAF LKQFLSDQRV IEIPKLLWKI ILYSFVLPFR 70 80 90 100 110 120 PKRVAHAYAS VWGQDSPMRE ILFAQTDALK RQLISHYPQL DLNIVPAMTY GNPGVQHILK 130 140 150 160 170 180 DLAASPQEHV ILLPLFPQYS ATSTAPLYDA FANWIPKQRH LPGLTIIKDY YRHPVFIQAL 190 200 210 220 230 240 VSSVQRFQQQ HGKPQKLLMS FHGIPQPYAD KGDPYADRCR ETARLVAKQL GLTPDDWAIS 250 260 270 280 290 300 FQSRFGKQEW VKPYTDELLT TWAANGIKSV QILSPAFSAD CLETLEELEI QNAELFLEAG 310 320 330 340 GTSYQYIPAL NTSVEHLELL RQLLQAHLDA LNYSLAYSAH

References

[1]

"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR543861 Genomic DNA. Translation: CAG69935.1.
RefSeq	YP_047757.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6F7N0.
Genome annotation databases
GeneID	2879992.
GenomeReviews	Gene locus ACIAD3255 in contig CR543861_GR.
KEGG	aci:ACIAD3255.
NMPDR	fig|62977.3.peg.2950.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0276.
HOGENOM	HBG697135.
OMA	TIEEIGM.
PhylomeDB	Q6F7N0.
Enzyme and pathway databases
BioCyc	ASP62977:ACIAD3255-MONOMER.
Family and domain databases
HAMAP	MF_00323. Ferrochelatase. [Tree]
InterPro	IPR001015. Ferrochelatase. IPR019772. Ferrochelatase_AS. [Graphical view]
PANTHER	PTHR11108. Ferrochelatase. 1 hit.
Pfam	PF00762. Ferrochelatase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00109. hemH. 1 hit.
PROSITE	PS00534. FERROCHELATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEMH_ACIAD

Accession

Primary (citable) accession number: Q6F7N0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	July 19, 2004
Last modified:	February 9, 2010
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)