Reviewed, UniProtKB/Swiss-Prot Q6F7E5 (AROB_ACIAD)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	ACIAD3353

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

62977 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	Divalent metal cations By similarity. HAMAP MF_00110 NAD By similarity. HAMAP MF_00110
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity. HAMAP MF_00110
Subcellular location	Cytoplasm Probable HAMAP MF_00110.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	3-dehydroquinate synthase HAMAP MF_00110		PRO_0000231060

Sequences

	Sequence		Length	Mass (Da)
	Q6F7E5-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 8D97CD4034D4AB3E	FASTA	362	39,743
	10 20 30 40 50 60 MQTLHVELGD RRYPIFIGSQ LNPQNLLAPY IKGRQVMIVT NTTLEQLYLQ HYQDALHALD 70 80 90 100 110 120 KQVAVCVLPD GEKYKNIEHL NLIFDALLKA GFNRDCTVLA LGGGVIGDMA GFAAASFQRG 130 140 150 160 170 180 VYFVQIPTTL LSQVDSSVGG KTGINHPLGK NMIGAFKQPE VVMADMSQLK TLPPRELSAG 190 200 210 220 230 240 LAEVIKYALL GDIEFLGWLE THMDGLIAGD ETLLAEAVYR SCAHKARIVA NDEKEQGERA 250 260 270 280 290 300 LLNLGHTFGH AIESYLGYGE WLHGEAVATG MVMAADLSHR LGWISSGDLE RTKKIIQRAN 310 320 330 340 350 360 LPISCPPIPL DEFLSYMSHD KKVLNGQLRL VLLQQLGQAI ITKTFDVEMM KAAILANQAS HT

References

[1]

"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR543861 Genomic DNA. Translation: CAG70020.1.
RefSeq	YP_047842.1.
3D structure databases
SMR	Q6F7E5. Positions 12-348.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6F7E5.
Genome annotation databases
GeneID	2878787.
GenomeReviews	Gene locus ACIAD3353 in contig CR543861_GR.
KEGG	aci:ACIAD3353.
NMPDR	fig|62977.3.peg.3035.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0337.
HOGENOM	HBG632303.
OMA	APESMDF.
PhylomeDB	Q6F7E5.
Enzyme and pathway databases
BioCyc	ASP62977:ACIAD3353-MONOMER.
Family and domain databases
HAMAP	MF_00110. DHQ_synthase. [Tree]
InterPro	IPR016303. DHQ_synth. IPR002658. DHQ_synth_AroB. IPR016037. DHQ_synth_AroB_sub. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. aroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_ACIAD

Accession

Primary (citable) accession number: Q6F7E5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	July 19, 2004
Last modified:	February 9, 2010
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)