Reviewed, UniProtKB/Swiss-Prot Q6F7E4 (AROK_ACIAD)

Names and origin

Protein names

Recommended name:
    Shikimate kinase
      Short name=SK
    EC=2.7.1.71

Gene names

Name:	aroK
Ordered Locus Names:	ACIAD3354

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

62977 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	180 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate By similarity.
Catalytic activity	ATP + shikimate = ADP + shikimate 3-phosphate. HAMAP MF_00109
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7. HAMAP MF_00109
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the shikimate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP shikimate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 180	180	Shikimate kinase HAMAP MF_00109		PRO_0000192364
Regions
	Nucleotide binding	19 – 24	6	ATP By similarity
Sites
	Metal binding	23	1	Magnesium By similarity
	Binding site	41	1	Substrate By similarity
	Binding site	65	1	Substrate By similarity
	Binding site	87	1	Substrate; via amide nitrogen By similarity
	Binding site	125	1	ATP By similarity
	Binding site	144	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6F7E4-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 465C3C033E32F6C7	FASTA	180	20,470
	10 20 30 40 50 60 MPSKEFDTLP NIYLVGPMGA GKTTVGRHLA ELLGREFLDS DHEIERRTGA TIPWIFEKEG 70 80 90 100 110 120 EIGFRSRETI VLDDLTSRRD LVLATGGGVV TQPANRSYLK TRGVVVYLYT PVELQLQRTY 130 140 150 160 170 180 RDKNRPLLQV ENPEQRLRDL LKLRDPLYRD VAHHIIETNQ GAARELAQQI LRVILSSGSH

References

[1]

"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR543861 Genomic DNA. Translation: CAG70021.1.
RefSeq	YP_047843.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6F7E4.
Genome annotation databases
GeneID	2878790.
GenomeReviews	Gene locus ACIAD3354 in contig CR543861_GR.
KEGG	aci:ACIAD3354.
NMPDR	fig|62977.3.peg.3036.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6F7E4.
OMA	HANVFFV.
Enzyme and pathway databases
BioCyc	ASP62977:ACIAD3354-MON.
Family and domain databases
HAMAP	MF_00109. [Tree]
InterPro	IPR000623. Shik_kinase. [Graphical view]
Pfam	PF01202. SKI. 1 hit. [Graphical view]
PRINTS	PR01100. SHIKIMTKNASE.
PROSITE	PS01128. SHIKIMATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROK_ACIAD

Accession

Primary (citable) accession number: Q6F7E4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	July 19, 2004
Last modified:	November 3, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)