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Q6F7D6 (MRAY_ACIAD) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:ACIAD3363
OrganismAcinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]
Taxonomic identifier62977 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length372 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 372372Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_0000108768

Regions

Transmembrane25 – 4521Helical; Potential
Transmembrane73 – 9321Helical; Potential
Transmembrane98 – 11821Helical; Potential
Transmembrane134 – 15421Helical; Potential
Transmembrane176 – 19621Helical; Potential
Transmembrane211 – 23121Helical; Potential
Transmembrane251 – 27121Helical; Potential
Transmembrane275 – 29521Helical; Potential
Transmembrane300 – 32021Helical; Potential
Transmembrane349 – 36921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q6F7D6 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: DB64B50383259295

FASTA37240,888
        10         20         30         40         50         60 
MLLWLFEHLS GYNSSFQVIR YLTLRSLLSI LTSLAIGLML GPVMIRKLQA LKYGQAVSSF 

        70         80         90        100        110        120 
APENHAKKMG TPTMGGVLIL MSIGISTLLW ADLSNPYVWI VLGVMVVFGA VGWADDWIKI 

       130        140        150        160        170        180 
RYKDNAGLPA RKKFFWTSVA SLGAGISLYV IAQNQPNPIH TANMLDLLIP FFKNLSIPLS 

       190        200        210        220        230        240 
AVPLGIAFII FTYLVINGAS NAVNLTDGLD GLAIMPIVMV AAGLGVFAYL AGDIRFANYL 

       250        260        270        280        290        300 
HIPYVKYTSE LVVICSAMVG AGLAFLWYNA HPAQIFMGDV GALALGAMLG TIAVMVRQEI 

       310        320        330        340        350        360 
VFAIMGGVFV MEAISVFLQI GSLRMRNKRV FLMAPLHHHY EKQGWKETQV VTRFWIITIM 

       370 
LVVLGLMTLK LR

« Hide

References

[1]"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium."
Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C.
Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ADP1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR543861 Genomic DNA. Translation: CAG70029.1.
RefSeqYP_047851.1. NC_005966.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ6F7D6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2878501.
GenomeReviewsGene locus ACIAD3363 in contig CR543861_GR.
KEGGaci:ACIAD3363.
NMPDRfig|62977.3.peg.3044.
PATRIC20744183. VBIAciSp98416_3006.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0472.
HOGENOMHBG708263.
OMARFWIISM.
PhylomeDBQ6F7D6.
ProtClustDBPRK00108.

Enzyme and pathway databases

BioCycASP62977:ACIAD3363-MONOMER.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_ACIAD
AccessionPrimary (citable) accession number: Q6F7D6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 19, 2004
Last modified: January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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