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Q6F703 (MURG_ACIAD) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
EC=2.4.1.227
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Gene names
Name:murG
Ordered Locus Names:ACIAD3517
OrganismAcinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]
Taxonomic identifier62977 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II) By similarity. HAMAP MF_00033

Catalytic activity

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00033

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00033

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity HAMAP MF_00033.

Sequence similarities

Belongs to the glycosyltransferase 28 family. MurG subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 365365UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase HAMAP MF_00033
PRO_0000225019

Sequences

Sequence LengthMass (Da)Tools
Q6F703 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 9093619A7FE556DC

FASTA36539,444
        10         20         30         40         50         60 
MTDPSQVKPK HVMMMAAGTG GHVFPALAVA KQLQQHGCQV SWLATPAGME NRLLKDQNIP 

        70         80         90        100        110        120 
IYQIDIQGVR GNGAVRKLLA PFKILKATYS AMRYMKQLKV DAVAGFGGYV AGPGGLAARI 

       130        140        150        160        170        180 
LGIPILIHEQ NAVAGFTNTQ LARVASKVCE AFPNTFPASA KRVTTGNPVR KEITAILSPK 

       190        200        210        220        230        240 
WRYDSREQAG QPLNILIVGG SLGAQALNER LPDALKNLNL PLNVFHQCGQ KQFEETRVRY 

       250        260        270        280        290        300 
TNAPANMSVQ VMPFIEDMAQ AYRDADLIIC RAGALTVTEV ATAGVAAVFV PLPIAVDDHQ 

       310        320        330        340        350        360 
TANARFLADV GAAKICQQST MTPENLDALL KPLMNRQLLS EMAVKARQHA QPNATQHVVD 


LIQTL

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References

[1]"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium."
Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C.
Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ADP1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR543861 Genomic DNA. Translation: CAG70162.1.
RefSeqYP_047984.1. NC_005966.1.

3D structure databases

ProteinModelPortalQ6F703.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6F703.

Protein family/group databases

CAZyGT28. Glycosyltransferase Family 28.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2880559.
GenomeReviewsGene locus ACIAD3517 in contig CR543861_GR.
KEGGaci:ACIAD3517.
NMPDRfig|62977.3.peg.3177.
PATRIC20744467. VBIAciSp98416_3142.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0707.
HOGENOMHBG617076.
OMAEDHQTKN.
PhylomeDBQ6F703.
ProtClustDBPRK00726.

Enzyme and pathway databases

BioCycASP62977:ACIAD3517-MONOMER.

Family and domain databases

HAMAPMF_00033. MurG.
[Tree]
InterProIPR006009. GlcNAc_MurG.
IPR004276. Glyco_trans_28.
IPR007235. Glyco_trans_28_C.
[Graphical view]
KOK02563.
PANTHERPTHR21015:SF22. PTHR21015:SF22. 1 hit.
PfamPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsTIGR01133. MurG. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURG_ACIAD
AccessionPrimary (citable) accession number: Q6F703
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 19, 2004
Last modified: January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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