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Protein

Orotate phosphoribosyltransferase

Gene

pyrE

Organism
Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from orotate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei305-phosphoribose 1-diphosphateUniRule annotation1
Binding sitei1025-phosphoribose 1-diphosphate; shared with dimeric partnerUniRule annotation1
Binding sitei1035-phosphoribose 1-diphosphateUniRule annotation1
Binding sitei1065-phosphoribose 1-diphosphate; shared with dimeric partnerUniRule annotation1
Binding sitei1085-phosphoribose 1-diphosphate; shared with dimeric partnerUniRule annotation1
Binding sitei132OrotateUniRule annotation1
Binding sitei160OrotateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processPyrimidine biosynthesis
LigandMagnesium

Enzyme and pathway databases

BioCyciASP62977:G1GJ8-3219-MONOMER
UniPathwayiUPA00070; UER00119

Names & Taxonomyi

Protein namesi
Recommended name:
Orotate phosphoribosyltransferaseUniRule annotation (EC:2.4.2.10UniRule annotation)
Short name:
OPRTUniRule annotation
Short name:
OPRTaseUniRule annotation
Gene namesi
Name:pyrEUniRule annotation
Ordered Locus Names:ACIAD3525
OrganismiAcinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Taxonomic identifieri62977 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter
Proteomesi
  • UP000000430 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001106611 – 216Orotate phosphoribosyltransferaseAdd BLAST216

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi62977.ACIAD3525

Structurei

3D structure databases

ProteinModelPortaliQ6F6Z6
SMRiQ6F6Z6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni38 – 39Orotate bindingUniRule annotation2
Regioni75 – 765-phosphoribose 1-diphosphate bindingUniRule annotation2
Regioni128 – 1365-phosphoribose 1-diphosphate bindingUniRule annotation9

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QP2 Bacteria
COG0461 LUCA
HOGENOMiHOG000037974
KOiK00762
OrthoDBiPOG091H034Q

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01208 PyrE, 1 hit
InterProiView protein in InterPro
IPR023031 OPRT
IPR004467 Or_phspho_trans_dom
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR00336 pyrE, 1 hit

Sequencei

Sequence statusi: Complete.

Q6F6Z6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTPSSFNPQ AFIELALSRG VLKFGEFTLK SGRVSPYFFN AGLLNDGEAL
60 70 80 90 100
SLLAQGYADQ LMQCQHVDVI FGPAYKGIPF VAATAVALSQ LHAKSVPWGF
110 120 130 140 150
NRKEAKDHGE GGVLVGASVE GKKVWIIDDV ITAGTAIREV VTILKNAGAT
160 170 180 190 200
IAGVLVALDR QERGQGQLSA IQEVQQELEI PVHALITMKD LMNYLDAKGE
210
TQALAKMEDY RLKYGI
Length:216
Mass (Da):23,336
Last modified:August 21, 2007 - v2
Checksum:iFA9F6067752858EE
GO

Sequence cautioni

The sequence CAG70169 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR543861 Genomic DNA Translation: CAG70169.1 Different initiation.
RefSeqiWP_004923310.1, NC_005966.1

Genome annotation databases

EnsemblBacteriaiCAG70169; CAG70169; ACIAD3525
KEGGiaci:ACIAD3525

Similar proteinsi

Entry informationi

Entry nameiPYRE_ACIAD
AccessioniPrimary (citable) accession number: Q6F6Z6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: August 21, 2007
Last modified: February 28, 2018
This is version 84 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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