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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:ACIAD3562
OrganismiAcinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Taxonomic identifieri62977 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter
Proteomesi
  • UP000000430 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002058161 – 407Nicotinate phosphoribosyltransferaseAdd BLAST407

Proteomic databases

PRIDEiQ6F6W1

Interactioni

Protein-protein interaction databases

STRINGi62977.ACIAD3562

Structurei

3D structure databases

ProteinModelPortaliQ6F6W1
SMRiQ6F6W1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RH7 Bacteria
COG1488 LUCA
HOGENOMiHOG000284928
KOiK00763
OMAiKLTMQCA
OrthoDBiPOG091H0197

Family and domain databases

CDDicd01401 PncB_like, 1 hit
HAMAPiMF_00570 NAPRTase, 1 hit
InterProiView protein in InterPro
IPR006406 Nic_PRibTrfase
IPR007229 Nic_PRibTrfase-Fam
IPR036068 Nicotinate_pribotase_like_C
PANTHERiPTHR11098 PTHR11098, 1 hit
PfamiView protein in Pfam
PF04095 NAPRTase, 1 hit
PIRSFiPIRSF000484 NAPRT, 1 hit
SUPFAMiSSF51690 SSF51690, 1 hit
TIGRFAMsiTIGR01514 NAPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

Q6F6W1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSMSPIIHS LLDTDLYKFT MLQVVLHQFP QTHSVYHFRC RNLDETQYPL
60 70 80 90 100
TDILDDLNEQ LDHLCTLKFK DDELQYLRSF RFIKSDFVDY LELFQLKRRF
110 120 130 140 150
ITAGIDEEGR LDIWVEGPMV QAMMFEIFVL AIVNELYFRR IRSDAVLEEG
160 170 180 190 200
ERRLQAKLAL LEQYQTQHQS DEPPFLVSDF GTRRRYSFEW QKHVIAAFHH
210 220 230 240 250
HFPNIFRGTS NVLLAKELNI TPIGTMAHEF LQAFQALDVR LRDFQKAALE
260 270 280 290 300
TWVQEYRGDL GIALTDVVGM DAFLRDFDLY FAKLFDGLRH DSGDPYEWGD
310 320 330 340 350
KAYAHYRKLK IDTKTKMLTF SDGLNLEKAW ELHQYFKGRF KVSFGIGTNL
360 370 380 390 400
TNDMGQTPLN IVLKLVECNG QSVAKISDSP GKTMTDNDTF LAYLRQVFQI

AEEEPVA
Length:407
Mass (Da):47,576
Last modified:July 19, 2004 - v1
Checksum:i549EAC3E9EFB05F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR543861 Genomic DNA Translation: CAG70204.1

Genome annotation databases

EnsemblBacteriaiCAG70204; CAG70204; ACIAD3562
KEGGiaci:ACIAD3562

Similar proteinsi

Entry informationi

Entry nameiPNCB_ACIAD
AccessioniPrimary (citable) accession number: Q6F6W1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 19, 2004
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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