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Protein

Protein TANC1

Gene

Tanc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be a scaffold component in the postsynaptic density.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TANC1
Alternative name(s):
TPR domain, ankyrin-repeat and coiled-coil domain-containing protein 1
Gene namesi
Name:Tanc1
Synonyms:Tanc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1302949. Tanc1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1849Missing : Abolishes interaction with DLG1, DLG4 and HOMER1. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003169611 – 1849Protein TANC1Add BLAST1849

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei60PhosphoserineBy similarity1
Modified residuei63PhosphoserineBy similarity1
Modified residuei64PhosphoserineBy similarity1
Modified residuei204PhosphoserineBy similarity1
Modified residuei267PhosphoserineBy similarity1
Modified residuei455PhosphoserineBy similarity1
Modified residuei1429PhosphoserineCombined sources1
Modified residuei1456PhosphoserineCombined sources1
Modified residuei1658PhosphoserineBy similarity1
Modified residuei1666PhosphoserineBy similarity1
Modified residuei1667PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated; by MINK1 and TNIK upon stimulation by RAP2A.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6F6B3.
PeptideAtlasiQ6F6B3.
PRIDEiQ6F6B3.

PTM databases

iPTMnetiQ6F6B3.
PhosphoSitePlusiQ6F6B3.

Expressioni

Tissue specificityi

Expressed in heart, lung, liver and kidney. Expressed in brain (at protein level).1 Publication

Developmental stagei

Detected as early as postnatal day one with increasing expression levels through 20 weeks after birth.

Interactioni

Subunit structurei

Interacts probably directly with DLG1, DLG4, HOMER1. Interacts with DLGAP1, INA, CAMK2A, GRIN2B and GRIA1. Interacts with TNIK and MINK1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TNIKQ9UKE52EBI-2133582,EBI-1051794From a different organism.

Protein-protein interaction databases

BioGridi259817. 11 interactors.
IntActiQ6F6B3. 2 interactors.
STRINGi10116.ENSRNOP00000033136.

Structurei

3D structure databases

ProteinModelPortaliQ6F6B3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati886 – 918ANK 1Add BLAST33
Repeati924 – 953ANK 2Add BLAST30
Repeati957 – 986ANK 3Add BLAST30
Repeati990 – 1019ANK 4Add BLAST30
Repeati1030 – 1059ANK 5Add BLAST30
Repeati1068 – 1097ANK 6Add BLAST30
Repeati1101 – 1130ANK 7Add BLAST30
Repeati1134 – 1163ANK 8Add BLAST30
Repeati1167 – 1196ANK 9Add BLAST30
Repeati1200 – 1229ANK 10Add BLAST30
Repeati1233 – 1262ANK 11Add BLAST30
Repeati1279 – 1312TPR 1Add BLAST34
Repeati1326 – 1359TPR 2Add BLAST34
Repeati1361 – 1393TPR 3Add BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi167 – 240Ser-richAdd BLAST74
Compositional biasi1640 – 1679Ser-richAdd BLAST40

Sequence similaritiesi

Belongs to the TANC family.Curated
Contains 11 ANK repeats.PROSITE-ProRule annotation
Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
HOGENOMiHOG000231045.
HOVERGENiHBG061464.
InParanoidiQ6F6B3.
PhylomeDBiQ6F6B3.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 10 hits.
SM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF48452. SSF48452. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6F6B3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKAVLKKSR EGVKGSKKEA GGDFGSETPT LSSSGDSPVN SLSTTEDTYR
60 70 80 90 100
VSLAKGVSMS LPSSPLLPRQ SHLTQSRANK KSPGPVRKPK YVESPRVPGD
110 120 130 140 150
PVMIPFREGS KPAEPIETEA KVDNEPSCSP AAQELLTRLG FLLGEGIPSA
160 170 180 190 200
THITIEDKNE AMCTALSQGI SPCSTLTSST ASPSTDSPCS TLNSCVSKTA
210 220 230 240 250
ANKSPCETIS SPSSTLESKD SGIIATITSS SENDDRSGSS LEWNRDGSLR
260 270 280 290 300
LGVQKGVLHD RRLDNCSPVA EEETTGSAES VLPKAESSAG DGPVPYSQSS
310 320 330 340 350
GSLIMPRPNS VAATSSTKLE DLSYLDGQRN APLRTSIRLP WHSTAGARFA
360 370 380 390 400
PYKPQEILLK PLLFEVPSIT TDSVFVGRDW LFQQIEENLR NTELAENRGA
410 420 430 440 450
VVVGNVGFGK TAIISKLVAL SCHGSRMRQV ASSSPSSSLK TSDPTHDLPG
460 470 480 490 500
TPLLSPSSST SALSAARTPP GPGTVDSQRP REDAVKYLAS RVVAYHYCQA
510 520 530 540 550
DNTYTCLVPE FVHSIATLLC RSHQLAAYRD LLIREPQLQS MLNLRSCVQD
560 570 580 590 600
PVAAFKRGIL EPLTNLRNEQ KIPEEEYIIL IDGLNEAEFH KPDHGDTLSS
610 620 630 640 650
FITKIIPKFP PWLKLIVTVR ADFQEIISTL PFVKLSLDDF PGNQDIHSDL
660 670 680 690 700
HAYVQHRVHS SQDILSNISL NGKADAALIG KVSSRLVLRN LGSYLYLKLT
710 720 730 740 750
LDLFQRGHLV IKSASYKVVP VSLSELYLLQ CNMKFMTQSA FDRALPILNV
760 770 780 790 800
ALASLHPMTD EQIFQAINAG HIQGEQGWED FQQKMEALSC FLIKKRDKTR
810 820 830 840 850
MFCHPSFREW LVWRADGEST AFLCEPRNGH ALLAFMFSRQ ESKLNRQQTV
860 870 880 890 900
ELGHHILKAH IFKGLSKKTG VSSSHPQALW IGYSTEGLSA ALASLRNLYT
910 920 930 940 950
PNVKVSRLLI LGGANVNYRT EVLNNAPILC VQSHLGHEEV VTLLLEFGAC
960 970 980 990 1000
LDGMSENGMN ALCYAAAAGH MKLVCLLTKK GARVDHLDKK GQCALVHSAL
1010 1020 1030 1040 1050
RGHSDILQYL LNCEWSAGPP QPGTLRKSQA LQQALTAAAS MGHSAVVQSL
1060 1070 1080 1090 1100
LGMAEEHEIE VNGTDTLWGE TALTAAAGRG KLEICELLLE RGAAVSRANR
1110 1120 1130 1140 1150
RGVPPLFCAA RQGHWQVVQL LLDRGCDVNP NDKQGRTPLM VAACEGHLST
1160 1170 1180 1190 1200
VEFLLSKGAA LSSLDKEGLS ALSWACLKGH RAVVQYLVEE GAEIDQTDKN
1210 1220 1230 1240 1250
GRTPLDLAAF YGDAETVLYL VEKGAVIEHV DHSGMRPLDR AIGCRNTAVV
1260 1270 1280 1290 1300
VTLLRKGAKL GNAAWAMATF KPDILIILLQ KLMEEGNVMY KKGKMKEAAQ
1310 1320 1330 1340 1350
RYQYALRKFP REGPGEDMRP FNELRVSLYL NLSRCRRKTN DFGLAEEFAS
1360 1370 1380 1390 1400
KALELKPKSY EAFYARARAK RNSRQFLAAL ADLQEAVKLC PTNQEIKRLL
1410 1420 1430 1440 1450
ARVEEECKQL QRNQQQKQQA PLPAPPNDSD NDEEAPASSL KDHFPIEEAE
1460 1470 1480 1490 1500
EEDTSSQEES ISPTPRSQPP PSVPSPYIRN LQEGLQSKGR PASPQSWAGI
1510 1520 1530 1540 1550
SKSLRETVAQ PGLVMQPTKQ AQIVKTNQHL GSGQSSMRNS NTKVQVSSQN
1560 1570 1580 1590 1600
PPPSPMPGRV SAAPAVSRNQ HLEGTGPFST GTGCGHFGDR LGPSQSLQLQ
1610 1620 1630 1640 1650
RGESGTAYPL PSKVKAAERL LAHASVAVDM ALPSQGGPVS CSDVRHPASL
1660 1670 1680 1690 1700
SSSGSSGSPS SSVKMSSSTS SLTSSSSVSD GFKAQGPDCR IRDRGTTQVQ
1710 1720 1730 1740 1750
GGTAEHRPRN TPFMGIMDKI ARFQQQVNPP SRSWHCPVTE GLLTNTATAA
1760 1770 1780 1790 1800
GLQTNSEKPA LKPGGYCSQA KPCSVPPLGM GVHNGAQVKE LEENKCQVPA
1810 1820 1830 1840
LCQDNRKTKG VPHLYPEGVS KQPLHVSTEA HRSHLTSAKP KRSFIESNV
Length:1,849
Mass (Da):200,507
Last modified:August 16, 2004 - v1
Checksum:iE52BA9EABF2ECECF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB098072 mRNA. Translation: BAD27523.1.
RefSeqiNP_001002854.1. NM_001002854.1.
UniGeneiRn.161791.

Genome annotation databases

GeneIDi311055.
KEGGirno:311055.
UCSCiRGD:1302949. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB098072 mRNA. Translation: BAD27523.1.
RefSeqiNP_001002854.1. NM_001002854.1.
UniGeneiRn.161791.

3D structure databases

ProteinModelPortaliQ6F6B3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi259817. 11 interactors.
IntActiQ6F6B3. 2 interactors.
STRINGi10116.ENSRNOP00000033136.

PTM databases

iPTMnetiQ6F6B3.
PhosphoSitePlusiQ6F6B3.

Proteomic databases

PaxDbiQ6F6B3.
PeptideAtlasiQ6F6B3.
PRIDEiQ6F6B3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi311055.
KEGGirno:311055.
UCSCiRGD:1302949. rat.

Organism-specific databases

CTDi85461.
RGDi1302949. Tanc1.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
HOGENOMiHOG000231045.
HOVERGENiHBG061464.
InParanoidiQ6F6B3.
PhylomeDBiQ6F6B3.

Miscellaneous databases

PROiQ6F6B3.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 10 hits.
SM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF48452. SSF48452. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTANC1_RAT
AccessioniPrimary (citable) accession number: Q6F6B3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 16, 2004
Last modified: November 30, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.