ID   Q6F5F2_MOUSE            Unreviewed;       391 AA.
AC   Q6F5F2; D3YXM3;
DT   16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT   16-AUG-2004, sequence version 1.
DT   27-MAR-2024, entry version 154.
DE   SubName: Full=SIRP-beta B-type {ECO:0000313|EMBL:BAD26608.1};
DE   SubName: Full=Signal-regulatory protein beta 1A {ECO:0000313|Ensembl:ENSMUSP00000141504.2};
GN   Name=Sirpb1a {ECO:0000313|Ensembl:ENSMUSP00000141504.2,
GN   ECO:0000313|MGI:MGI:2444824};
GN   Synonyms=SIRP-beta {ECO:0000313|EMBL:BAD26608.1};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:BAD26608.1};
RN   [1] {ECO:0000313|EMBL:BAD26608.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6 {ECO:0000313|EMBL:BAD26608.1};
RC   TISSUE=Spleen {ECO:0000313|EMBL:BAD26608.1};
RX   PubMed=15123631; DOI=10.1074/jbc.M400950200;
RA   Hayashi A., Ohnishi H., Okazawa H., Nakazawa S., Ikeda H., Motegi S.,
RA   Aoki N., Kimura S., Mikuni M., Matozaki T.;
RT   "Positive regulation of phagocytosis by SIRPbeta and its signaling
RT   mechanism in macrophages.";
RL   J. Biol. Chem. 279:29450-29460(2004).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000141504.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000141504.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000141504.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000141504.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AB112022; BAD26608.1; -; mRNA.
DR   RefSeq; NP_001002898.1; NM_001002898.1.
DR   STRING; 10090.ENSMUSP00000141504; -.
DR   PaxDb; 10090-ENSMUSP00000096807; -.
DR   ProteomicsDB; 340765; -.
DR   DNASU; 320832; -.
DR   Ensembl; ENSMUST00000192700.3; ENSMUSP00000141504.2; ENSMUSG00000095788.7.
DR   GeneID; 320832; -.
DR   KEGG; mmu:320832; -.
DR   UCSC; uc008oqw.1; mouse.
DR   AGR; MGI:2444824; -.
DR   CTD; 320832; -.
DR   MGI; MGI:2444824; Sirpb1a.
DR   VEuPathDB; HostDB:ENSMUSG00000095788; -.
DR   eggNOG; ENOG502S1XD; Eukaryota.
DR   GeneTree; ENSGT00960000186656; -.
DR   HOGENOM; CLU_044430_0_0_1; -.
DR   OrthoDB; 5401342at2759; -.
DR   TreeFam; TF341862; -.
DR   BioGRID-ORCS; 320832; 2 hits in 57 CRISPR screens.
DR   ChiTaRS; Sirpb1a; mouse.
DR   Proteomes; UP000000589; Chromosome 3.
DR   Bgee; ENSMUSG00000095788; Expressed in granulocyte and 39 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; ISO:MGI.
DR   GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR   GO; GO:0051649; P:establishment of localization in cell; IDA:MGI.
DR   GO; GO:0035556; P:intracellular signal transduction; IDA:MGI.
DR   GO; GO:0006909; P:phagocytosis; IDA:MGI.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; IDA:MGI.
DR   GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central.
DR   CDD; cd05772; IgC1_SIRP_domain_2; 1.
DR   CDD; cd16085; IgC1_SIRP_domain_3; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   PANTHER; PTHR19971; SIGNAL-REGULATORY PROTEIN BETA; 1.
DR   PANTHER; PTHR19971:SF11; SIGNAL-REGULATORY PROTEIN BETA 1A-RELATED; 1.
DR   Pfam; PF07654; C1-set; 2.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 2.
DR   SMART; SM00407; IGc1; 2.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 3.
DR   PROSITE; PS50835; IG_LIKE; 3.
PE   2: Evidence at transcript level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        364..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          11..118
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          146..245
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          252..340
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
SQ   SEQUENCE   391 AA;  43491 MW;  56F8EBDB4CE89B7D CRC64;
     MLLLDAWTHI PHSVLLLILL LGFKGAAVRE LKVIQPVKSF FVGAGGSATL NCTVTSLLPV
     GPIRWYRGVG QSRLLIYPFT GEHSPRITNV SDVTKRNNMD FSIRISNVTP ADSGTYYCVK
     FQRGSSEPDI EIQSGGGTEL LVLAKPSSPM VSGPAARAVP QQTVTFTCRS HGFFPRNLTL
     KWFKNGDEIS HLETSVEPEE TSVSYRVSST VQVVLEPRDV RSQIICEVDH VTLDRAPLRG
     IAHISEFIQV PPTLEIRQQP TMVWNVINVT CQIQKFYPPS FQLTWLENGN ISRREVPFTL
     IVNKDGTYNW ISCLLVNISA LEENMVVTCK VEHDEQAEVI ETHTVLVTEH QRVKELKTAG
     IAKIPVAVLL GSKILLLIAA TVIYMHKKQN A
//