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Protein
Submitted name:

SIRP-beta B-type

Gene

SIRP-beta

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • intracellular signal transduction Source: MGI
  • positive regulation of phagocytosis Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-202733. Cell surface interactions at the vascular wall.
R-MMU-2172127. DAP12 interactions.
R-MMU-391160. Signal regulatory protein (SIRP) family interactions.
R-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Submitted name:
SIRP-beta B-typeImported
Submitted name:
Signal-regulatory protein beta 1AImported
Gene namesi
Name:SIRP-betaImported
Synonyms:Sirpb1aImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2444824. Sirpb1a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei364 – 385HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: GOC
  • plasma membrane Source: MGI

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiQ6F5F2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000095788.
ExpressionAtlasiQ6F5F2. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096807.

Structurei

3D structure databases

ProteinModelPortaliQ6F5F2.
SMRiQ6F5F2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 118Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST108
Domaini146 – 245Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST100
Domaini252 – 340Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST89

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IKYM. Eukaryota.
ENOG410YKK2. LUCA.
GeneTreeiENSGT00440000033339.
HOGENOMiHOG000230874.
HOVERGENiHBG056632.
KOiK06551.
TreeFamiTF341862.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
PfamiView protein in Pfam
PF07654. C1-set. 2 hits.
PF07686. V-set. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 2 hits.
SM00407. IGc1. 2 hits.
SM00406. IGv. 1 hit.
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 3 hits.

Sequencei

Sequence statusi: Complete.

Q6F5F2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLDAWTHI PHSVLLLILL LGFKGAAVRE LKVIQPVKSF FVGAGGSATL
60 70 80 90 100
NCTVTSLLPV GPIRWYRGVG QSRLLIYPFT GEHSPRITNV SDVTKRNNMD
110 120 130 140 150
FSIRISNVTP ADSGTYYCVK FQRGSSEPDI EIQSGGGTEL LVLAKPSSPM
160 170 180 190 200
VSGPAARAVP QQTVTFTCRS HGFFPRNLTL KWFKNGDEIS HLETSVEPEE
210 220 230 240 250
TSVSYRVSST VQVVLEPRDV RSQIICEVDH VTLDRAPLRG IAHISEFIQV
260 270 280 290 300
PPTLEIRQQP TMVWNVINVT CQIQKFYPPS FQLTWLENGN ISRREVPFTL
310 320 330 340 350
IVNKDGTYNW ISCLLVNISA LEENMVVTCK VEHDEQAEVI ETHTVLVTEH
360 370 380 390
QRVKELKTAG IAKIPVAVLL GSKILLLIAA TVIYMHKKQN A
Length:391
Mass (Da):43,491
Last modified:August 16, 2004 - v1
Checksum:i56F8EBDB4CE89B7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC152069 Genomic DNA. No translation available.
AC161359 Genomic DNA. No translation available.
AB112022 mRNA. Translation: BAD26608.1.
RefSeqiNP_001002898.1. NM_001002898.1.
UniGeneiMm.330924.
Mm.423523.
Mm.425126.

Genome annotation databases

EnsembliENSMUST00000192700; ENSMUSP00000141504; ENSMUSG00000095788.
GeneIDi320832.
KEGGimmu:320832.
UCSCiuc008oqw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC152069 Genomic DNA. No translation available.
AC161359 Genomic DNA. No translation available.
AB112022 mRNA. Translation: BAD26608.1.
RefSeqiNP_001002898.1. NM_001002898.1.
UniGeneiMm.330924.
Mm.423523.
Mm.425126.

3D structure databases

ProteinModelPortaliQ6F5F2.
SMRiQ6F5F2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096807.

Proteomic databases

MaxQBiQ6F5F2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000192700; ENSMUSP00000141504; ENSMUSG00000095788.
GeneIDi320832.
KEGGimmu:320832.
UCSCiuc008oqw.1. mouse.

Organism-specific databases

CTDi320832.
MGIiMGI:2444824. Sirpb1a.

Phylogenomic databases

eggNOGiENOG410IKYM. Eukaryota.
ENOG410YKK2. LUCA.
GeneTreeiENSGT00440000033339.
HOGENOMiHOG000230874.
HOVERGENiHBG056632.
KOiK06551.
TreeFamiTF341862.

Enzyme and pathway databases

ReactomeiR-MMU-202733. Cell surface interactions at the vascular wall.
R-MMU-2172127. DAP12 interactions.
R-MMU-391160. Signal regulatory protein (SIRP) family interactions.
R-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000095788.
ExpressionAtlasiQ6F5F2. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
PfamiView protein in Pfam
PF07654. C1-set. 2 hits.
PF07686. V-set. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 2 hits.
SM00407. IGc1. 2 hits.
SM00406. IGv. 1 hit.
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6F5F2_MOUSE
AccessioniPrimary (citable) accession number: Q6F5F2
Secondary accession number(s): D3YXM3
Entry historyiIntegrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: April 12, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.