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Q6F5F2

- Q6F5F2_MOUSE

UniProt

Q6F5F2 - Q6F5F2_MOUSE

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Protein
Submitted name:

Protein Sirpb1a

Gene

SIRP-beta

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

ReactomeiREACT_188188. DAP12 interactions.
REACT_215628. Signal regulatory protein (SIRP) family interactions.
REACT_225233. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Sirpb1aImported
Submitted name:
SIRP-beta B-typeImported
Gene namesi
Name:SIRP-betaImported
Synonyms:Sirpb1aImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:2444824. Sirpb1a.

Expressioni

Gene expression databases

GenevestigatoriQ6F5F2.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096807.

Structurei

3D structure databases

SMRiQ6F5F2. Positions 30-339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00440000033339.
HOGENOMiHOG000230874.
HOVERGENiHBG056632.
KOiK06551.
OrthoDBiEOG7CG6ZQ.
PhylomeDBiQ6F5F2.
TreeFamiTF341862.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07654. C1-set. 2 hits.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00407. IGc1. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6F5F2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLLDAWTHI PHSVLLLILL LGFKGAAVRE LKVIQPVKSF FVGAGGSATL
60 70 80 90 100
NCTVTSLLPV GPIRWYRGVG QSRLLIYPFT GEHSPRITNV SDVTKRNNMD
110 120 130 140 150
FSIRISNVTP ADSGTYYCVK FQRGSSEPDI EIQSGGGTEL LVLAKPSSPM
160 170 180 190 200
VSGPAARAVP QQTVTFTCRS HGFFPRNLTL KWFKNGDEIS HLETSVEPEE
210 220 230 240 250
TSVSYRVSST VQVVLEPRDV RSQIICEVDH VTLDRAPLRG IAHISEFIQV
260 270 280 290 300
PPTLEIRQQP TMVWNVINVT CQIQKFYPPS FQLTWLENGN ISRREVPFTL
310 320 330 340 350
IVNKDGTYNW ISCLLVNISA LEENMVVTCK VEHDEQAEVI ETHTVLVTEH
360 370 380 390
QRVKELKTAG IAKIPVAVLL GSKILLLIAA TVIYMHKKQN A
Length:391
Mass (Da):43,491
Last modified:August 16, 2004 - v1
Checksum:i56F8EBDB4CE89B7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC152069 Genomic DNA. No translation available.
AB112022 mRNA. Translation: BAD26608.1.
RefSeqiNP_001002898.1. NM_001002898.1.
UniGeneiMm.330924.
Mm.423523.
Mm.425126.

Genome annotation databases

EnsembliENSMUST00000099201; ENSMUSP00000096807; ENSMUSG00000095788.
GeneIDi320832.
KEGGimmu:320832.
UCSCiuc008oqw.1. mouse.
uc008ore.4. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC152069 Genomic DNA. No translation available.
AB112022 mRNA. Translation: BAD26608.1 .
RefSeqi NP_001002898.1. NM_001002898.1.
UniGenei Mm.330924.
Mm.423523.
Mm.425126.

3D structure databases

SMRi Q6F5F2. Positions 30-339.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000096807.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000099201 ; ENSMUSP00000096807 ; ENSMUSG00000095788 .
GeneIDi 320832.
KEGGi mmu:320832.
UCSCi uc008oqw.1. mouse.
uc008ore.4. mouse.

Organism-specific databases

CTDi 320832.
MGIi MGI:2444824. Sirpb1a.

Phylogenomic databases

GeneTreei ENSGT00440000033339.
HOGENOMi HOG000230874.
HOVERGENi HBG056632.
KOi K06551.
OrthoDBi EOG7CG6ZQ.
PhylomeDBi Q6F5F2.
TreeFami TF341862.

Enzyme and pathway databases

Reactomei REACT_188188. DAP12 interactions.
REACT_215628. Signal regulatory protein (SIRP) family interactions.
REACT_225233. Cell surface interactions at the vascular wall.

Miscellaneous databases

NextBioi 35549337.
SOURCEi Search...

Gene expression databases

Genevestigatori Q6F5F2.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07654. C1-set. 2 hits.
PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00407. IGc1. 2 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Positive regulation of phagocytosis by SIRPbeta and its signaling mechanism in macrophages."
    Hayashi A., Ohnishi H., Okazawa H., Nakazawa S., Ikeda H., Motegi S., Aoki N., Kimura S., Mikuni M., Matozaki T.
    J. Biol. Chem. 279:29450-29460(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6Imported.
    Tissue: SpleenImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ6F5F2_MOUSE
AccessioniPrimary (citable) accession number: Q6F5F2
Secondary accession number(s): D3YXM3
Entry historyi
Integrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: January 7, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.