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Protein
Submitted name:

SIRP-beta B-type

Gene

SIRP-beta

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • intracellular signal transduction Source: MGI
  • positive regulation of phagocytosis Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-202733. Cell surface interactions at the vascular wall.
R-MMU-2172127. DAP12 interactions.
R-MMU-391160. Signal regulatory protein family interactions.
R-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Submitted name:
SIRP-beta B-typeImported
Submitted name:
Signal-regulatory protein beta 1AImported
Gene namesi
Name:SIRP-betaImported
Synonyms:Sirpb1aImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2444824. Sirpb1a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei364 – 385HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000095788.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096807.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 118Ig-likeInterPro annotationAdd BLAST108
Domaini146 – 245Ig-likeInterPro annotationAdd BLAST100
Domaini252 – 340Ig-likeInterPro annotationAdd BLAST89

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IKYM. Eukaryota.
ENOG410YKK2. LUCA.
GeneTreeiENSGT00440000033339.
HOGENOMiHOG000230874.
HOVERGENiHBG056632.
KOiK06551.
TreeFamiTF341862.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
PfamiView protein in Pfam
PF07654. C1-set. 2 hits.
PF07686. V-set. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 2 hits.
SM00407. IGc1. 2 hits.
SM00406. IGv. 1 hit.
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 3 hits.

Sequencei

Sequence statusi: Complete.

Q6F5F2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLDAWTHI PHSVLLLILL LGFKGAAVRE LKVIQPVKSF FVGAGGSATL
60 70 80 90 100
NCTVTSLLPV GPIRWYRGVG QSRLLIYPFT GEHSPRITNV SDVTKRNNMD
110 120 130 140 150
FSIRISNVTP ADSGTYYCVK FQRGSSEPDI EIQSGGGTEL LVLAKPSSPM
160 170 180 190 200
VSGPAARAVP QQTVTFTCRS HGFFPRNLTL KWFKNGDEIS HLETSVEPEE
210 220 230 240 250
TSVSYRVSST VQVVLEPRDV RSQIICEVDH VTLDRAPLRG IAHISEFIQV
260 270 280 290 300
PPTLEIRQQP TMVWNVINVT CQIQKFYPPS FQLTWLENGN ISRREVPFTL
310 320 330 340 350
IVNKDGTYNW ISCLLVNISA LEENMVVTCK VEHDEQAEVI ETHTVLVTEH
360 370 380 390
QRVKELKTAG IAKIPVAVLL GSKILLLIAA TVIYMHKKQN A
Length:391
Mass (Da):43,491
Last modified:August 16, 2004 - v1
Checksum:i56F8EBDB4CE89B7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC152069 Genomic DNA. No translation available.
AC161359 Genomic DNA. No translation available.
AB112022 mRNA. Translation: BAD26608.1.
RefSeqiNP_001002898.1. NM_001002898.1.
UniGeneiMm.330924.
Mm.423523.
Mm.425126.

Genome annotation databases

EnsembliENSMUST00000192700; ENSMUSP00000141504; ENSMUSG00000095788.
GeneIDi320832.
KEGGimmu:320832.
UCSCiuc008oqw.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiQ6F5F2_MOUSE
AccessioniPrimary (citable) accession number: Q6F5F2
Secondary accession number(s): D3YXM3
Entry historyiIntegrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: September 27, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported