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Protein
Submitted name:

SIRP-beta B-type

Gene

Sirpb1a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • intracellular signal transduction Source: MGI
  • positive regulation of phagocytosis Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-2172127 DAP12 interactions
R-MMU-391160 Signal regulatory protein family interactions
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Submitted name:
SIRP-beta B-typeImported
Submitted name:
Signal-regulatory protein beta 1AImported
Gene namesi
Name:Sirpb1aImported
Synonyms:SIRP-betaImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2444824 Sirpb1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei364 – 385HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiQ6F5F2

Expressioni

Gene expression databases

BgeeiENSMUSG00000095788

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096807

Structurei

3D structure databases

SMRiQ6F5F2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 118Ig-likeInterPro annotationAdd BLAST108
Domaini146 – 245Ig-likeInterPro annotationAdd BLAST100
Domaini252 – 340Ig-likeInterPro annotationAdd BLAST89

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IKYM Eukaryota
ENOG410YKK2 LUCA
GeneTreeiENSGT00440000033339
HOGENOMiHOG000230874
HOVERGENiHBG056632
KOiK06551
TreeFamiTF341862

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07654 C1-set, 2 hits
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00407 IGc1, 2 hits
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

Sequencei

Sequence statusi: Complete.

Q6F5F2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLDAWTHI PHSVLLLILL LGFKGAAVRE LKVIQPVKSF FVGAGGSATL
60 70 80 90 100
NCTVTSLLPV GPIRWYRGVG QSRLLIYPFT GEHSPRITNV SDVTKRNNMD
110 120 130 140 150
FSIRISNVTP ADSGTYYCVK FQRGSSEPDI EIQSGGGTEL LVLAKPSSPM
160 170 180 190 200
VSGPAARAVP QQTVTFTCRS HGFFPRNLTL KWFKNGDEIS HLETSVEPEE
210 220 230 240 250
TSVSYRVSST VQVVLEPRDV RSQIICEVDH VTLDRAPLRG IAHISEFIQV
260 270 280 290 300
PPTLEIRQQP TMVWNVINVT CQIQKFYPPS FQLTWLENGN ISRREVPFTL
310 320 330 340 350
IVNKDGTYNW ISCLLVNISA LEENMVVTCK VEHDEQAEVI ETHTVLVTEH
360 370 380 390
QRVKELKTAG IAKIPVAVLL GSKILLLIAA TVIYMHKKQN A
Length:391
Mass (Da):43,491
Last modified:August 16, 2004 - v1
Checksum:i56F8EBDB4CE89B7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC152069 Genomic DNA No translation available.
AC161359 Genomic DNA No translation available.
AB112022 mRNA Translation: BAD26608.1
RefSeqiNP_001002898.1, NM_001002898.1
UniGeneiMm.330924
Mm.423523
Mm.425126

Genome annotation databases

EnsembliENSMUST00000192700; ENSMUSP00000141504; ENSMUSG00000095788
GeneIDi320832
KEGGimmu:320832
UCSCiuc008oqw.1 mouse

Similar proteinsi

Entry informationi

Entry nameiQ6F5F2_MOUSE
AccessioniPrimary (citable) accession number: Q6F5F2
Secondary accession number(s): D3YXM3
Entry historyiIntegrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: April 25, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health