Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Geranylgeranyl pyrophosphate synthase

Gene

Ggps1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.

Catalytic activityi

Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.

Cofactori

Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity

Pathwayi: farnesyl diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Farnesyl pyrophosphate synthase (Fdps), Geranylgeranyl pyrophosphate synthase (Ggps1)
This subpathway is part of the pathway farnesyl diphosphate biosynthesis, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate, the pathway farnesyl diphosphate biosynthesis and in Isoprenoid biosynthesis.

Pathwayi: geranyl diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Farnesyl pyrophosphate synthase (Fdps), Geranylgeranyl pyrophosphate synthase (Ggps1)
This subpathway is part of the pathway geranyl diphosphate biosynthesis, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate, the pathway geranyl diphosphate biosynthesis and in Isoprenoid biosynthesis.

Pathwayi: geranylgeranyl diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Geranylgeranyl pyrophosphate synthase (Ggps1)
This subpathway is part of the pathway geranylgeranyl diphosphate biosynthesis, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate, the pathway geranylgeranyl diphosphate biosynthesis and in Isoprenoid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei25Isopentenyl diphosphateBy similarity1
Binding sitei28Isopentenyl diphosphateBy similarity1
Binding sitei57Isopentenyl diphosphateBy similarity1
Metal bindingi64Magnesium 1By similarity1
Metal bindingi64Magnesium 2By similarity1
Metal bindingi68Magnesium 1By similarity1
Metal bindingi68Magnesium 2By similarity1
Binding sitei73Dimethylallyl diphosphateBy similarity1
Binding sitei74Isopentenyl diphosphateBy similarity1
Binding sitei151Dimethylallyl diphosphateBy similarity1
Binding sitei152Dimethylallyl diphosphateBy similarity1
Binding sitei185Dimethylallyl diphosphateBy similarity1
Metal bindingi188Magnesium 3By similarity1
Binding sitei202Dimethylallyl diphosphateBy similarity1
Binding sitei212Dimethylallyl diphosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processIsoprene biosynthesis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BRENDAi2.5.1.29 5301
ReactomeiR-RNO-191273 Cholesterol biosynthesis
UniPathwayiUPA00259; UER00368
UPA00260; UER00369
UPA00389; UER00564

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranyl pyrophosphate synthase (EC:2.5.1.-)
Short name:
GGPP synthase
Short name:
GGPPSase
Alternative name(s):
(2E,6E)-farnesyl diphosphate synthase
Dimethylallyltranstransferase (EC:2.5.1.1)
Farnesyl diphosphate synthase
Farnesyltranstransferase (EC:2.5.1.29)
Geranylgeranyl diphosphate synthase
Geranyltranstransferase (EC:2.5.1.10)
Gene namesi
Name:Ggps1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi1359680 Ggps1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001239641 – 300Geranylgeranyl pyrophosphate synthaseAdd BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ6F596
PRIDEiQ6F596

PTM databases

iPTMnetiQ6F596
PhosphoSitePlusiQ6F596

Expressioni

Gene expression databases

BgeeiENSRNOG00000016767
ExpressionAtlasiQ6F596 baseline and differential
GenevisibleiQ6F596 RN

Interactioni

Subunit structurei

Homohexamer; trimer of homodimers.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022483

Structurei

3D structure databases

ProteinModelPortaliQ6F596
SMRiQ6F596
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FPP/GGPP synthase family.Curated

Phylogenomic databases

eggNOGiKOG0777 Eukaryota
COG0142 LUCA
GeneTreeiENSGT00390000010417
HOGENOMiHOG000169461
HOVERGENiHBG051729
InParanoidiQ6F596
KOiK00804
OMAiFYSKAFF
PhylomeDBiQ6F596
TreeFamiTF300101

Family and domain databases

Gene3Di1.10.600.10, 1 hit
InterProiView protein in InterPro
IPR008949 Isoprenoid_synthase_dom_sf
IPR000092 Polyprenyl_synt
IPR033749 Polyprenyl_synt_CS
PfamiView protein in Pfam
PF00348 polyprenyl_synt, 1 hit
SUPFAMiSSF48576 SSF48576, 1 hit
PROSITEiView protein in PROSITE
PS00723 POLYPRENYL_SYNTHASE_1, 1 hit
PS00444 POLYPRENYL_SYNTHASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6F596-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKTKEKAER ILLEPYKYLL QLPGKQVRTK LSQAFNHWLK VPEDKLQIII
60 70 80 90 100
EVTEMLHNAS LLIDDIEDSS KLRRGFPVAH SIYGVPSVIN SANYVYFLGL
110 120 130 140 150
EKVLTLDHPD AVKLFTRQLL ELHQGQGLDI YWRDTYTCPT EEEYKAMVLQ
160 170 180 190 200
KTGGLFGLAV GLMQLFSDYK EDLKPLLDTL GLFFQIRDDY ANLHSKEYSE
210 220 230 240 250
NKSFCEDLTE GKFSFPTIHA IWSRPESTQV QNILRQRTEN IDIKKYCVQY
260 270 280 290 300
LEDVGSFEYT RYTLRELEAK AYKQIEACGG NPSLVALVKH LSKMFTEENE
Length:300
Mass (Da):34,778
Last modified:August 16, 2004 - v1
Checksum:iA3C47E3F9BB81876
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB118237 Genomic DNA Translation: BAD30051.1
AB118238 mRNA Translation: BAD30052.1
AB118239 mRNA Translation: BAD30053.1
AB118240 mRNA Translation: BAD30054.1
BC090327 mRNA Translation: AAH90327.1
RefSeqiNP_001007627.1, NM_001007626.2
UniGeneiRn.54975

Genome annotation databases

EnsembliENSRNOT00000022483; ENSRNOP00000022483; ENSRNOG00000016767
ENSRNOT00000080101; ENSRNOP00000073229; ENSRNOG00000016767
GeneIDi291211
KEGGirno:291211
UCSCiRGD:1359680 rat

Similar proteinsi

Entry informationi

Entry nameiGGPPS_RAT
AccessioniPrimary (citable) accession number: Q6F596
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health