Reviewed,
UniProtKB/Swiss-Prot Q6F596 (GGPPS_RAT)
Last modified
November 25, 2008.
Version 44.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Geranylgeranyl pyrophosphate synthetase Short name=GGPP synthetase Short name=GGPPSase Alternative name(s): Geranylgeranyl diphosphate synthase Including the following 3 domains: 1- Recommended name: Dimethylallyltranstransferase EC=2.5.1.1 2- Recommended name: Geranyltranstransferase EC=2.5.1.10 3- Recommended name: Farnesyltranstransferase EC=2.5.1.29 | ||
| Gene names |
| ||
| Organism | Rattus norvegicus (Rat) | ||
| Taxonomic identifier | 10116 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 300 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins. |
| Catalytic activity | Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate. Trans,trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate. |
| Pathway | |
| Subunit structure | Homooctamer By similarity. |
| Subcellular location | CytoplasmPotential. |
| Sequence similarities | Belongs to the FPP/GGPP synthetase family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Isoprene biosynthesis |
| Cellular component | Cytoplasm |
| Molecular function | Transferase |
| Technical term | Multifunctional enzyme |
Gene Ontology (GO) | |
| Biological process | isoprenoid biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW soluble fractionInferred from sequence or structural similarity. Source: UniProtKB |
| Molecular function | dimethylallyltranstransferase activity Inferred from electronic annotation. Source: EC farnesyltranstransferase activityInferred from sequence or structural similarity. Source: UniProtKB geranyltranstransferase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 300 | 300 | Geranylgeranyl pyrophosphate synthetase | PRO_0000123964 | |||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Relationship between intron 4b splicing of the rat geranylgeranyl diphosphate synthase gene and the active enzyme expression level." Matsumura Y., Kuzuguchi T., Sagami H. J. Biochem. 136:301-312(2004) [PubMed: 15598886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Testis. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung. |
Cross-references
Sequence databases | |
|---|---|
| AB118237 Genomic DNA. Translation: BAD30051.1. AB118238 mRNA. Translation: BAD30052.1. AB118239 mRNA. Translation: BAD30053.1. AB118240 mRNA. Translation: BAD30054.1. BC090327 mRNA. Translation: AAH90327.1. | |
| RefSeq | NP_001007627.1. |
| UniGene | Rn.54975 |
3D structure databases | |
| SMR | Q6F596. Positions 6-295. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSRNOG00000016767. Rattus norvegicus. [Contig view] |
| GeneID | 291211. |
| KEGG | rno:291211. |
| NMPDR | fig|10116.3.peg.13440. |
Organism-specific databases | |
| RGD | 1359680. Ggps1. |
Phylogenomic databases | |
| HOVERGEN | Q6F596. |
Gene expression databases | |
| ArrayExpress | Q6F596. |
| GermOnline | ENSRNOG00000016767. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR000092. Polyprenyl_synt. IPR017446. Polyprenyl_synth-rel. IPR008949. Terpenoid_synth. [Graphical view] |
| Gene3D | G3DSA:1.10.600.10. Terpenoid_synth. 1 hit. |
| PANTHER | PTHR12001. Polyprenyl_synt. 1 hit. |
| Pfam | PF00348. polyprenyl_synt. 1 hit. [Graphical view] |
| PROSITE | PS00723. POLYPRENYL_SYNTHET_1. 1 hit. PS00444. POLYPRENYL_SYNTHET_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 632273. |
Entry information
| Entry name | GGPPS_RAT | ||||||||
| Accession | Primary (citable) accession number: Q6F596 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


