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Reviewed, UniProtKB/Swiss-Prot Q6F596 (GGPPS_RAT)

Last modified January 19, 2010. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Geranylgeranyl pyrophosphate synthetase
      Short name=GGPP synthetase
      Short name=GGPPSase
Alternative name(s):
    Geranylgeranyl diphosphate synthase
Including the following 3 domains:
    1- Recommended name:
            Dimethylallyltranstransferase
              EC=2.5.1.1
    2- Recommended name:
            Geranyltranstransferase
              EC=2.5.1.10
    3- Recommended name:
            Farnesyltranstransferase
              EC=2.5.1.29
Gene names
Name: Ggps1
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length300 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.

Catalytic activity

Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.

Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate.

Trans,trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.

Cofactor

Binds 3 magnesium ions per subunit By similarity.

Pathway

Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.

Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.

Isoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1.

Subunit structure

Homohexamer; trimer of homodimers By similarity.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the FPP/GGPP synthetase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 300300Geranylgeranyl pyrophosphate synthetase
PRO_0000123964

Sites

Metal binding641Magnesium 1 By similarity
Metal binding641Magnesium 2 By similarity
Metal binding681Magnesium 1 By similarity
Metal binding681Magnesium 2 By similarity
Metal binding1881Magnesium 3 By similarity
Binding site251Isopentenyl diphosphate By similarity
Binding site281Isopentenyl diphosphate By similarity
Binding site571Isopentenyl diphosphate By similarity
Binding site731Dimethylallyl diphosphate By similarity
Binding site741Isopentenyl diphosphate By similarity
Binding site1511Dimethylallyl diphosphate By similarity
Binding site1521Dimethylallyl diphosphate By similarity
Binding site1851Dimethylallyl diphosphate By similarity
Binding site2021Dimethylallyl diphosphate By similarity
Binding site2121Dimethylallyl diphosphate By similarity

Amino acid modifications

Modified residue251N6-acetyllysine By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q6F596-1 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: A3C47E3F9BB81876

FASTA30034,778
        10         20         30         40         50         60 
MEKTKEKAER ILLEPYKYLL QLPGKQVRTK LSQAFNHWLK VPEDKLQIII EVTEMLHNAS 

        70         80         90        100        110        120 
LLIDDIEDSS KLRRGFPVAH SIYGVPSVIN SANYVYFLGL EKVLTLDHPD AVKLFTRQLL 

       130        140        150        160        170        180 
ELHQGQGLDI YWRDTYTCPT EEEYKAMVLQ KTGGLFGLAV GLMQLFSDYK EDLKPLLDTL 

       190        200        210        220        230        240 
GLFFQIRDDY ANLHSKEYSE NKSFCEDLTE GKFSFPTIHA IWSRPESTQV QNILRQRTEN 

       250        260        270        280        290        300 
IDIKKYCVQY LEDVGSFEYT RYTLRELEAK AYKQIEACGG NPSLVALVKH LSKMFTEENE

« Hide

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References

« Hide 'large scale' references
[1]"Relationship between intron 4b splicing of the rat geranylgeranyl diphosphate synthase gene and the active enzyme expression level."
Matsumura Y., Kuzuguchi T., Sagami H.
J. Biochem. 136:301-312(2004) [PubMed: 15598886] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Tissue: Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB118237 Genomic DNA. Translation: BAD30051.1.
AB118238 mRNA. Translation: BAD30052.1.
AB118239 mRNA. Translation: BAD30053.1.
AB118240 mRNA. Translation: BAD30054.1.
BC090327 mRNA. Translation: AAH90327.1.
IPIIPI00363014.
RefSeqNP_001007627.1.
UniGeneRn.54975

3D structure databases

SMRQ6F596. Positions 6-295.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6F596.

Genome annotation databases

EnsemblENSRNOT00000022483; ENSRNOP00000022483; ENSRNOG00000016767; Rattus norvegicus. [Genome view]
GeneID291211.
KEGGrno:291211.
NMPDRfig|10116.3.peg.13440.
UCSCNM_001007626. rat.

Organism-specific databases

CTD291211.
RGD1359680. Ggps1.

Phylogenomic databases

eggNOGroNOG11131.
HOVERGENQ6F596.
InParanoidQ6F596.
OMADIEDNSI.
OrthoDBEOG9G7FJM.
PhylomeDBQ6F596.

Enzyme and pathway databases

BRENDA2.5.1.1. 248.
2.5.1.10. 248.
2.5.1.29. 248.

Gene expression databases

ArrayExpressQ6F596.
GenevestigatorQ6F596.
GermOnlineENSRNOG00000016767. Rattus norvegicus.

Family and domain databases

InterProIPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view]
Gene3DG3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
PANTHERPTHR12001. Polyprenyl_synt. 1 hit.
PfamPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
PROSITEPS00723. POLYPRENYL_SYNTHET_1. 1 hit.
PS00444. POLYPRENYL_SYNTHET_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio632273.

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Entry information

Entry nameGGPPS_RAT
AccessionPrimary (citable) accession number: Q6F596
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: August 16, 2004
Last modified: January 19, 2010
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents