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Protein

Curculin-2

Gene
N/A
Organism
Molineria latifolia (Lumbah) (Curculigo latifolia)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Taste-modifying protein; sweet-tasting. After curculin, water elicits a sweet taste, and sour substances induce a stronger sense of sweetness.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Taste-modifying protein

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Curculin-2
Alternative name(s):
Neoculin acidic subunit
Short name:
NAS
OrganismiMolineria latifolia (Lumbah) (Curculigo latifolia)
Taxonomic identifieri4676 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaAsparagalesHypoxidaceaeMolineria

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000036621223 – 135Curculin-2Add BLAST113
PropeptideiPRO_0000366213136 – 158Add BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 74
Disulfide bondi99Interchain (with C-131 in NBS)
Glycosylationi103N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi131Interchain (with C-99 in NBS)

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Heterodimer with curculin-1; Disulfide-linked.2 Publications

Structurei

Secondary structure

1158
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi25 – 27Combined sources3
Beta strandi36 – 40Combined sources5
Beta strandi43 – 47Combined sources5
Beta strandi53 – 57Combined sources5
Beta strandi60 – 64Combined sources5
Beta strandi75 – 78Combined sources4
Beta strandi84 – 87Combined sources4
Beta strandi93 – 95Combined sources3
Beta strandi102 – 104Combined sources3
Beta strandi107 – 110Combined sources4
Beta strandi116 – 119Combined sources4
Beta strandi124 – 130Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D04X-ray2.76A/C/E/G23-135[»]
ProteinModelPortaliQ6F495.
SMRiQ6F495.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6F495.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 131Bulb-type lectinPROSITE-ProRule annotationAdd BLAST109

Sequence similaritiesi

Contains 1 bulb-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.90.10.10. 1 hit.
InterProiIPR001480. Bulb-type_lectin_dom.
[Graphical view]
PfamiPF01453. B_lectin. 1 hit.
[Graphical view]
SMARTiSM00108. B_lectin. 1 hit.
[Graphical view]
SUPFAMiSSF51110. SSF51110. 1 hit.
PROSITEiPS50927. BULB_LECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6F495-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKFLLTIL VTFAAVASLG MADSVLLSGQ TLYAGHSLTS GSYTLTIQNN
60 70 80 90 100
CNLVKYQHGR QIWASDTDGQ GSQCRLTLRS DGNLIIYDDN NMVVWGSDCW
110 120 130 140 150
GNNGTYALVL QQDGLFVIYG PVLWPLGLNG CRSLNGEITV AKDSTEPQHE

DIKMVINN
Length:158
Mass (Da):17,174
Last modified:August 16, 2004 - v1
Checksum:iCE597B53F069FFE1
GO

Sequence cautioni

The sequence BAE45253 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti80S → N.1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB167079 mRNA. Translation: BAD29946.1.
AB167080 mRNA. Translation: BAE45253.1. Different initiation.
AB181490 mRNA. Translation: BAD38841.1.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB167079 mRNA. Translation: BAD29946.1.
AB167080 mRNA. Translation: BAE45253.1. Different initiation.
AB181490 mRNA. Translation: BAD38841.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D04X-ray2.76A/C/E/G23-135[»]
ProteinModelPortaliQ6F495.
SMRiQ6F495.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ6F495.

Family and domain databases

Gene3Di2.90.10.10. 1 hit.
InterProiIPR001480. Bulb-type_lectin_dom.
[Graphical view]
PfamiPF01453. B_lectin. 1 hit.
[Graphical view]
SMARTiSM00108. B_lectin. 1 hit.
[Graphical view]
SUPFAMiSSF51110. SSF51110. 1 hit.
PROSITEiPS50927. BULB_LECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCURC2_MOLLA
AccessioniPrimary (citable) accession number: Q6F495
Secondary accession number(s): Q3MV17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: August 16, 2004
Last modified: November 2, 2016
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.