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Protein

Curculin-2

Gene
N/A
Organism
Molineria latifolia (Lumbah) (Curculigo latifolia)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Taste-modifying protein; sweet-tasting. After curculin, water elicits a sweet taste, and sour substances induce a stronger sense of sweetness.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Taste-modifying protein

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Curculin-2
Alternative name(s):
Neoculin acidic subunit
Short name:
NAS
OrganismiMolineria latifolia (Lumbah) (Curculigo latifolia)
Taxonomic identifieri4676 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaAsparagalesHypoxidaceaeMolineria

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Chaini23 – 135113Curculin-2PRO_0000366212Add
BLAST
Propeptidei136 – 15823PRO_0000366213Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 74
Disulfide bondi99 – 99Interchain (with C-131 in NBS)
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence analysis
Disulfide bondi131 – 131Interchain (with C-99 in NBS)

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Heterodimer with curculin-1; Disulfide-linked.2 Publications

Structurei

Secondary structure

1
158
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi25 – 273Combined sources
Beta strandi36 – 405Combined sources
Beta strandi43 – 475Combined sources
Beta strandi53 – 575Combined sources
Beta strandi60 – 645Combined sources
Beta strandi75 – 784Combined sources
Beta strandi84 – 874Combined sources
Beta strandi93 – 953Combined sources
Beta strandi102 – 1043Combined sources
Beta strandi107 – 1104Combined sources
Beta strandi116 – 1194Combined sources
Beta strandi124 – 1307Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2D04X-ray2.76A/C/E/G23-135[»]
ProteinModelPortaliQ6F495.
SMRiQ6F495. Positions 23-135.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6F495.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 131109Bulb-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 bulb-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.90.10.10. 1 hit.
InterProiIPR001480. Bulb-type_lectin_dom.
[Graphical view]
PfamiPF01453. B_lectin. 1 hit.
[Graphical view]
SMARTiSM00108. B_lectin. 1 hit.
[Graphical view]
SUPFAMiSSF51110. SSF51110. 1 hit.
PROSITEiPS50927. BULB_LECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6F495-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKFLLTIL VTFAAVASLG MADSVLLSGQ TLYAGHSLTS GSYTLTIQNN
60 70 80 90 100
CNLVKYQHGR QIWASDTDGQ GSQCRLTLRS DGNLIIYDDN NMVVWGSDCW
110 120 130 140 150
GNNGTYALVL QQDGLFVIYG PVLWPLGLNG CRSLNGEITV AKDSTEPQHE

DIKMVINN
Length:158
Mass (Da):17,174
Last modified:August 16, 2004 - v1
Checksum:iCE597B53F069FFE1
GO

Sequence cautioni

The sequence BAE45253 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti80 – 801S → N.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB167079 mRNA. Translation: BAD29946.1.
AB167080 mRNA. Translation: BAE45253.1. Different initiation.
AB181490 mRNA. Translation: BAD38841.1.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB167079 mRNA. Translation: BAD29946.1.
AB167080 mRNA. Translation: BAE45253.1. Different initiation.
AB181490 mRNA. Translation: BAD38841.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2D04X-ray2.76A/C/E/G23-135[»]
ProteinModelPortaliQ6F495.
SMRiQ6F495. Positions 23-135.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ6F495.

Family and domain databases

Gene3Di2.90.10.10. 1 hit.
InterProiIPR001480. Bulb-type_lectin_dom.
[Graphical view]
PfamiPF01453. B_lectin. 1 hit.
[Graphical view]
SMARTiSM00108. B_lectin. 1 hit.
[Graphical view]
SUPFAMiSSF51110. SSF51110. 1 hit.
PROSITEiPS50927. BULB_LECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCURC2_MOLLA
AccessioniPrimary (citable) accession number: Q6F495
Secondary accession number(s): Q3MV17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: August 16, 2004
Last modified: October 14, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.