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Protein

G-protein coupled receptor 126

Gene

Gpr126

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 126
Alternative name(s):
Developmentally regulated G-protein-coupled receptor
Gene namesi
Name:Gpr126
Synonyms:Dreg, Gm222
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1916151. Gpr126.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 832802ExtracellularSequence analysisAdd
BLAST
Transmembranei833 – 85321Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini854 – 87320CytoplasmicSequence analysisAdd
BLAST
Transmembranei874 – 89421Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini895 – 8995ExtracellularSequence analysis
Transmembranei900 – 92021Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini921 – 94020CytoplasmicSequence analysisAdd
BLAST
Transmembranei941 – 96121Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini962 – 99433ExtracellularSequence analysisAdd
BLAST
Transmembranei995 – 101521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini1016 – 103924CytoplasmicSequence analysisAdd
BLAST
Transmembranei1040 – 106021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini1061 – 10622ExtracellularSequence analysis
Transmembranei1063 – 108321Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini1084 – 116582CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence analysisAdd
BLAST
Chaini31 – 11651135G-protein coupled receptor 126PRO_0000303888Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 67PROSITE-ProRule annotation
Disulfide bondi94 ↔ 111PROSITE-ProRule annotation
Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence analysis
Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence analysis
Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence analysis
Glycosylationi314 – 3141N-linked (GlcNAc...)1 Publication
Glycosylationi324 – 3241N-linked (GlcNAc...)Sequence analysis
Glycosylationi353 – 3531N-linked (GlcNAc...)Sequence analysis
Glycosylationi370 – 3701N-linked (GlcNAc...)Sequence analysis
Glycosylationi410 – 4101N-linked (GlcNAc...)Sequence analysis
Glycosylationi417 – 4171N-linked (GlcNAc...)Sequence analysis
Glycosylationi424 – 4241N-linked (GlcNAc...)Sequence analysis
Glycosylationi458 – 4581N-linked (GlcNAc...)Sequence analysis
Glycosylationi462 – 4621N-linked (GlcNAc...)Sequence analysis
Glycosylationi478 – 4781N-linked (GlcNAc...)Sequence analysis
Glycosylationi536 – 5361N-linked (GlcNAc...)Sequence analysis
Glycosylationi549 – 5491N-linked (GlcNAc...)Sequence analysis
Glycosylationi563 – 5631N-linked (GlcNAc...)Sequence analysis
Glycosylationi570 – 5701N-linked (GlcNAc...)Sequence analysis
Glycosylationi665 – 6651N-linked (GlcNAc...)Sequence analysis
Glycosylationi674 – 6741N-linked (GlcNAc...)Sequence analysis
Glycosylationi720 – 7201N-linked (GlcNAc...)Sequence analysis
Glycosylationi746 – 7461N-linked (GlcNAc...)Sequence analysis
Glycosylationi781 – 7811N-linked (GlcNAc...)Sequence analysis
Glycosylationi788 – 7881N-linked (GlcNAc...)Sequence analysis
Modified residuei1135 – 11351PhosphoserineCombined sources
Modified residuei1138 – 11381PhosphoserineCombined sources

Post-translational modificationi

Proteolytically cleaved into 2 conserved sites: one in the GPS domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. Furin is involved in the cleavage of the S2 site generating a soluble fragment. Processing at the GPS domain occurred independent of and probably prior to the cleavage at the S2 site. Proteolytic cleavage is required for activation of the receptor (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei447 – 4482Cleavage; by furin like-convertase
Sitei810 – 8112Cleavage

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ6F3F9.
PaxDbiQ6F3F9.
PeptideAtlasiQ6F3F9.
PRIDEiQ6F3F9.

PTM databases

iPTMnetiQ6F3F9.
PhosphoSiteiQ6F3F9.

Expressioni

Tissue specificityi

Expressed at high levels in the heart and somite during embryogenesis and in adult lung.1 Publication

Gene expression databases

BgeeiENSMUSG00000039116.
CleanExiMM_GPR126.
GenevisibleiQ6F3F9. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043055.

Structurei

3D structure databases

ProteinModelPortaliQ6F3F9.
SMRiQ6F3F9. Positions 43-146, 833-1085.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 149109CUBPROSITE-ProRule annotationAdd
BLAST
Domaini150 – 355206PentaxinAdd
BLAST
Domaini770 – 82253GPSPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni41 – 822782Inhibits receptor signaling in absence of type IV collagenBy similarityAdd
BLAST
Regioni41 – 355315Mediates interaction with type IV collagenBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1123 – 116543Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 CUB domain.PROSITE-ProRule annotation
Contains 1 GPS domain.PROSITE-ProRule annotation
Contains 1 pentaxin domain.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3714. Eukaryota.
KOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128227.
HOGENOMiHOG000112768.
HOVERGENiHBG051778.
InParanoidiQ6F3F9.
KOiK08463.
OrthoDBiEOG091G00P5.
PhylomeDBiQ6F3F9.
TreeFamiTF321769.

Family and domain databases

Gene3Di2.60.120.290. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR000859. CUB_dom.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR001759. Pentaxin-related.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF00431. CUB. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00042. CUB. 1 hit.
SM00303. GPS. 1 hit.
SM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6F3F9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFDTLGKRC CPWRLKPSAL LFLFVLCVTC VPLSVCGCGS CRLVLSNPSG
60 70 80 90 100
TFTSPCYPND YPNTQSCSWT LRAPAGYIIQ ITFNDFDIEE APNCIYDSLS
110 120 130 140 150
LDNGESQTKF CGATAKGLSF NSSVNEMHVS FSSDFSIQKK GFNASYIRVA
160 170 180 190 200
VSLRNQKVIL PQTLDAYQVS VAKSISIPEL KAFTLCFEAS KVGNEGGDWT
210 220 230 240 250
AFSYSDESLT QLLSLEKASN GYFLSISGSR CLLNNALPVK DKEDIFTENL
260 270 280 290 300
EQLCLVWNNS WGSIGINFKK NYETVPCDST ISAVVPGDGT LLLGSDRDEV
310 320 330 340 350
ASLRGSIYNF RLWNFTMDLK ALSNLSCSVS GNVIDWHNDF WSISTQALKA
360 370 380 390 400
EGNLSCGSYL IQLPAAELTN CSELGTLCQD GIMYRISVVI HNDFNHPEVK
410 420 430 440 450
VQTKVAEWLN STFQNWNYTV YVVNISFHQK VGEDRMKVKR DIMDDDKRLV
460 470 480 490 500
LWALLVYNAT NNVSLNEEKI KQKLMTNNAS LEDGLRLCEV DVNQLGMCSA
510 520 530 540 550
LEDPDGFSWP ATLPSVYKQP CPNKPGFFMT RACLSNGTST FWGPVDTSNC
560 570 580 590 600
SRQSNEVANE ILNQTGDGQN LTSANINSIV EKVKRIVNKE ENIDITLGST
610 620 630 640 650
LMNIFSNILS SSDSDLLESS TEALKTIDEL AFKIDLNSTP HVNIETQNLA
660 670 680 690 700
LGVSSLIPGT NAPSNFSIGL PSNNESYFQM DFGNGQTDPL ASVILPPNLL
710 720 730 740 750
ENLSPEDSVL VRRAQFTFFN KTGLFQDVGS QRKVLVSYVM ACSIGNITIQ
760 770 780 790 800
NLKDPVQIKI KHTRTQEVHH PICAFWDMNK NKSFGGWNTS GCVAHSDLDA
810 820 830 840 850
GETICLCSHF THFGVLMDLP RSASQIDGRN TKVLTFITYI GCGISAIFSA
860 870 880 890 900
ATLLTYVAFE KLRRDYPSKI LMNLSSALLF LNLIFLLDGW VTSFGVAGLC
910 920 930 940 950
TAVAALLHFF LLATFTWMGL EAIHMYIALV KVFNTYIHRY ILKFCIIGWG
960 970 980 990 1000
LPALVVSIIL VSRRQNEVYG KESYGKDQDD EFCWIQDPVV FYVSCAGYFG
1010 1020 1030 1040 1050
VMFFLNVAMF IVVMVQICGR NGKRSNRTLR EEVLRNLRSV VSLTFLLGMT
1060 1070 1080 1090 1100
WGFAFFAWGP LNIPFMYLFS IFNSLQGLFI FIFHCAMKEN VQKQWRRHLC
1110 1120 1130 1140 1150
CGRFRLADNS DWSKTATNII KKSSDNLGKS LSSSSIGSNS TYLTSKSKSS
1160
STTYFKRNSH SDNFS
Length:1,165
Mass (Da):129,721
Last modified:August 16, 2004 - v1
Checksum:iB5CC5CDEAA42CB50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB183545 mRNA. Translation: BAD27570.1.
BC046534 mRNA. Translation: AAH46534.1.
CCDSiCCDS35848.1.
RefSeqiNP_001002268.1. NM_001002268.3.
UniGeneiMm.440142.

Genome annotation databases

EnsembliENSMUST00000041168; ENSMUSP00000043055; ENSMUSG00000039116.
GeneIDi215798.
KEGGimmu:215798.
UCSCiuc007elk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB183545 mRNA. Translation: BAD27570.1.
BC046534 mRNA. Translation: AAH46534.1.
CCDSiCCDS35848.1.
RefSeqiNP_001002268.1. NM_001002268.3.
UniGeneiMm.440142.

3D structure databases

ProteinModelPortaliQ6F3F9.
SMRiQ6F3F9. Positions 43-146, 833-1085.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043055.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ6F3F9.
PhosphoSiteiQ6F3F9.

Proteomic databases

MaxQBiQ6F3F9.
PaxDbiQ6F3F9.
PeptideAtlasiQ6F3F9.
PRIDEiQ6F3F9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041168; ENSMUSP00000043055; ENSMUSG00000039116.
GeneIDi215798.
KEGGimmu:215798.
UCSCiuc007elk.1. mouse.

Organism-specific databases

CTDi57211.
MGIiMGI:1916151. Gpr126.

Phylogenomic databases

eggNOGiKOG3714. Eukaryota.
KOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128227.
HOGENOMiHOG000112768.
HOVERGENiHBG051778.
InParanoidiQ6F3F9.
KOiK08463.
OrthoDBiEOG091G00P5.
PhylomeDBiQ6F3F9.
TreeFamiTF321769.

Miscellaneous databases

PROiQ6F3F9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039116.
CleanExiMM_GPR126.
GenevisibleiQ6F3F9. MM.

Family and domain databases

Gene3Di2.60.120.290. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR000859. CUB_dom.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR001759. Pentaxin-related.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF00431. CUB. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00042. CUB. 1 hit.
SM00303. GPS. 1 hit.
SM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP126_MOUSE
AccessioniPrimary (citable) accession number: Q6F3F9
Secondary accession number(s): Q811E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: August 16, 2004
Last modified: September 7, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.