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Q6F1U6 (GUAC_MESFL) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GMP reductase
EC=1.7.1.7
Alternative name(s):
Guanosine 5'-monophosphate oxidoreductase
Short name=Guanosine monophosphate reductase
Gene names
Name:guaC
Ordered Locus Names:Mfl170
OrganismMesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1) (Acholeplasma florum)
Taxonomic identifier265311 [NCBI]
Taxonomic lineageBacteria › Tenericutes › Mollicutes › Entomoplasmatales › Entomoplasmataceae › Mesoplasma

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity. HAMAP MF_01511

Catalytic activity

Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. HAMAP MF_01511

Sequence similarities

Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.

Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processpurine nucleotide metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionGMP reductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 320320GMP reductase HAMAP MF_01511
PRO_0000294277

Regions

Nucleotide binding203 – 22624NADP Potential

Sites

Active site1741Thioimidate intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6F1U6 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 53933FE2937D8CCD

FASTA32035,585
        10         20         30         40         50         60 
MYAFDYEDIQ LIPNMCVVNS RSECNTSVTL GKHTFKMPVV PANMATVINE ELSIMLAEKN 

        70         80         90        100        110        120 
YFYVMHRFDF DAVSFIKKMK EKKLISSISV GVKEQDFKMI NELTELNLIP DYITIDIAHG 

       130        140        150        160        170        180 
HANSVKEMIE HIRTKMGDQT FIIAGNVATP QAVRDLEHWG ADATKVGVGP GKVCITKLKT 

       190        200        210        220        230        240 
GFGTGGWQLG AIKWCSKAAT KPIIADGGLR VNGDIAKSIR FGATMCMIGS LFAAHEESPG 

       250        260        270        280        290        300 
KNVTVDNVLF KEYYGSASEY NKGEKRYVEG KKELIKVRGK LMDTYKEMEE DLQSSISYAG 

       310        320 
GKTLKAIKKV DYVILKTSNF

« Hide

References

[1]Birren B.W., Stange-Thomann N., Hafez N., DeCaprio D., Fisher S., Butler J., Elkins T., Kodira C.D., Major J., Wang S., Nicol R., Nusbaum C.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33453 / NBRC 100688 / NCTC 11704 / L1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017263 Genomic DNA. Translation: AAT75527.1.
RefSeqYP_053411.1. NC_006055.1.

3D structure databases

HSSPHSSP built from PDB template 1YPF based on UniProtKB Q81JJ9.
ProteinModelPortalQ6F1U6.
SMRQ6F1U6. Positions 4-320.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2898130.
GenomeReviewsGene locus Mfl170 in contig AE017263_GR.
KEGGmfl:Mfl170.
PATRIC22473067. VBIMesFlo3168_0171.

Phylogenomic databases

HOGENOMHBG298985.
OMAPDYITID.
ProtClustDBPRK05458.

Enzyme and pathway databases

BioCycMFLO265311:MFL170-MONOMER.

Family and domain databases

HAMAPMF_01511. GMP_reduct_type2.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR005994. GMP_reduct2.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK00364.
PANTHERPTHR11911:SF30. PTHR11911:SF30. 1 hit.
PfamPF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFPIRSF036500. GMP_red_Firmic. 1 hit.
TIGRFAMsTIGR01306. GMP_reduct_2. 1 hit.
PROSITEPS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGUAC_MESFL
AccessionPrimary (citable) accession number: Q6F1U6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: August 16, 2004
Last modified: January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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