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Q6F1S1 (KGUA_MESFL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanylate kinase

EC=2.7.4.8
Alternative name(s):
GMP kinase
Gene names
Name:gmk
Ordered Locus Names:Mfl195
OrganismMesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1) (Acholeplasma florum) [Reference proteome] [HAMAP]
Taxonomic identifier265311 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesEntomoplasmatalesEntomoplasmataceaeMesoplasma

Protein attributes

Sequence length297 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP-Rule MF_00328

Catalytic activity

ATP + GMP = ADP + GDP. HAMAP-Rule MF_00328

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00328.

Sequence similarities

Belongs to the guanylate kinase family.

Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpurine nucleotide metabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

guanylate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 297297Guanylate kinase HAMAP-Rule MF_00328
PRO_0000266346

Regions

Domain5 – 184180Guanylate kinase-like
Nucleotide binding12 – 198ATP By similarity
Region205 – 29793Unknown HAMAP-Rule MF_00328

Sequences

Sequence LengthMass (Da)Tools
Q6F1S1 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 94B819C9B7191BA2

FASTA29733,826
        10         20         30         40         50         60 
MKNKGKVIII SGPSGVGKGS VNGELLTNKD LKLEYSVSMT TRAPREGEVN GVNYFFVSKE 

        70         80         90        100        110        120 
EFANAIVNNE LIEYANFVGN SYGTPRKYVE EKLNEGKNVI LEIEVDGATQ VLRNEENVLS 

       130        140        150        160        170        180 
IFLMPPTLNE LESRIKGRAT ESDDKIKARL DKALLEIPLK HNYDYVVEND SVENAVSKIT 

       190        200        210        220        230        240 
DILIREKCTE SNEESKFKEL VKIVENIVDQ KYTYFINNWE ANVKLLAHNK EAKKEANDFD 

       250        260        270        280        290 
ARGELIKILS SEVYRKTLAH GDFSKINDVE YVDFKIQKLM FKINFFSIKQ RSDFSGD 

« Hide

References

[1]Birren B.W., Stange-Thomann N., Hafez N., DeCaprio D., Fisher S., Butler J., Elkins T., Kodira C.D., Major J., Wang S., Nicol R., Nusbaum C.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33453 / NBRC 100688 / NCTC 11704 / L1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017263 Genomic DNA. Translation: AAT75552.1.
RefSeqYP_053436.1. NC_006055.1.

3D structure databases

ProteinModelPortalQ6F1S1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING265311.Mfl195.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAT75552; AAT75552; Mfl195.
GeneID2898173.
KEGGmfl:Mfl195.
PATRIC22473117. VBIMesFlo3168_0196.

Phylogenomic databases

eggNOGCOG0194.
HOGENOMHOG000037639.
KOK00942.
OMAADEMSHY.
OrthoDBEOG6CP410.

Enzyme and pathway databases

BioCycMFLO265311:GHIB-216-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_00328. Guanylate_kinase.
InterProIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR03263. guanyl_kin. 1 hit.
PROSITEPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKGUA_MESFL
AccessionPrimary (citable) accession number: Q6F1S1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: August 16, 2004
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families