ID   Q6F1P5_MESFL            Unreviewed;       386 AA.
AC   Q6F1P5;
DT   16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT   16-AUG-2004, sequence version 1.
DT   27-MAR-2024, entry version 122.
DE   SubName: Full=Probable serine/threonine protein kinase {ECO:0000313|EMBL:AAT75578.1};
GN   OrderedLocusNames=Mfl221 {ECO:0000313|EMBL:AAT75578.1};
OS   Mesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1)
OS   (Acholeplasma florum).
OC   Bacteria; Mycoplasmatota; Mollicutes; Entomoplasmatales;
OC   Entomoplasmataceae; Mesoplasma.
OX   NCBI_TaxID=265311 {ECO:0000313|EMBL:AAT75578.1, ECO:0000313|Proteomes:UP000006647};
RN   [1] {ECO:0000313|EMBL:AAT75578.1, ECO:0000313|Proteomes:UP000006647}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33453 / NBRC 100688 / NCTC 11704 / L1
RC   {ECO:0000313|Proteomes:UP000006647};
RA   Birren B.W., Stange-Thomann N., Hafez N., DeCaprio D., Fisher S.,
RA   Butler J., Elkins T., Kodira C.D., Major J., Wang S., Nicol R., Nusbaum C.;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001433};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR   EMBL; AE017263; AAT75578.1; -; Genomic_DNA.
DR   RefSeq; WP_011183118.1; NC_006055.1.
DR   RefSeq; YP_053462.1; NC_006055.1.
DR   AlphaFoldDB; Q6F1P5; -.
DR   STRING; 265311.Mfl221; -.
DR   PaxDb; 265311-Mfl221; -.
DR   EnsemblBacteria; AAT75578; AAT75578; Mfl221.
DR   GeneID; 2898246; -.
DR   KEGG; mfl:Mfl221; -.
DR   PATRIC; fig|265311.5.peg.221; -.
DR   eggNOG; COG0515; Bacteria.
DR   HOGENOM; CLU_000288_63_44_14; -.
DR   OrthoDB; 9788659at2; -.
DR   Proteomes; UP000006647; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd14014; STKc_PknB_like; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR24345; SERINE/THREONINE-PROTEIN KINASE PLK; 1.
DR   PANTHER; PTHR24345:SF0; SERINE_THREONINE-PROTEIN KINASE PLK1; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Kinase {ECO:0000313|EMBL:AAT75578.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000006647};
KW   Serine/threonine-protein kinase {ECO:0000313|EMBL:AAT75578.1};
KW   Transferase {ECO:0000313|EMBL:AAT75578.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        366..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          27..323
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   BINDING         61
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   386 AA;  44507 MW;  756671D16538A8FF CRC64;
     MQDEKKYTRI DEIPVDYFAN KKISGNYLLI NEIGRGTFGL VYKAKDLSNQ NYSSESFLAI
     KLMFVPNIKN ENDRLREQEI RDEIKKYSTQ IFNPRVVKIQ DYLQWENFLL IVMEYVDGQS
     LQDMLKEKDG TLTFEEIIYY FSEIALGLQG VHDMNMIHRD IKPGNILLSK DKKIKITDFG
     ISHVKGFVYE GGNAKKTLKP SSPGTPRFAS PEQYIETDSS SEDKVSFQSD IYSLGVMMYE
     ATTGVELIKI NDPRLFKPQD DKARKDRNSY LLDQTLVAEI VSPSVINPSI DKSLEYIIMK
     CLEKNVAERY KTANEVARDL KAIGRGEKII IKKSKNEPYR TDSIKKLENE NKKFNTFIST
     FINAKVVPIV ACIFIIFVLL IFVLIW
//