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Q6F1N5 (RNC_MESFL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease 3

EC=3.1.26.3
Alternative name(s):
Ribonuclease III
Short name=RNase III
Gene names
Name:rnc
Ordered Locus Names:Mfl231
OrganismMesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1) (Acholeplasma florum) [Reference proteome] [HAMAP]
Taxonomic identifier265311 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesEntomoplasmatalesEntomoplasmataceaeMesoplasma

Protein attributes

Sequence length231 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon By similarity. HAMAP-Rule MF_00104

Catalytic activity

Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP-Rule MF_00104

Cofactor

Mg2+ By similarity. HAMAP-Rule MF_00104

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00104

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00104.

Sequence similarities

Contains 1 DRBM (double-stranded RNA-binding) domain.

Contains 1 RNase III domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 231231Ribonuclease 3 HAMAP-Rule MF_00104
PRO_0000228547

Regions

Domain3 – 130128RNase III
Domain157 – 22872DRBM

Sites

Active site471 Potential
Active site1191 By similarity
Metal binding431Magnesium By similarity
Metal binding1161Magnesium By similarity
Metal binding1191Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6F1N5 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 602CFC7DCE911A2B

FASTA23126,602
        10         20         30         40         50         60 
MTMHEFFENF GIKINDSKIF STALTHNSYA NETKTKETYQ RLEFLGDAVL QMYVSKFLYL 

        70         80         90        100        110        120 
NFTNAPEGKL TKTRSDIVRQ ETLSEIAKMI DLGKIIRLGQ GEIKSKGYEK PSILSDVYEA 

       130        140        150        160        170        180 
VTAAIYLDQT EEVLISWIKS TIFKYIEKND YKELNHDYKS ELQEIIQAEI RSDLEYRVES 

       190        200        210        220        230 
QKHIEKDNKI EYTVSVNLDG KKYGIGTGFS KQEASQNAAK DCLNKLKKSA K 

« Hide

References

[1]Birren B.W., Stange-Thomann N., Hafez N., DeCaprio D., Fisher S., Butler J., Elkins T., Kodira C.D., Major J., Wang S., Nicol R., Nusbaum C.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33453 / NBRC 100688 / NCTC 11704 / L1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017263 Genomic DNA. Translation: AAT75588.1.
RefSeqYP_053472.1. NC_006055.1.

3D structure databases

ProteinModelPortalQ6F1N5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING265311.Mfl231.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAT75588; AAT75588; Mfl231.
GeneID2897980.
KEGGmfl:Mfl231.
PATRIC22473189. VBIMesFlo3168_0231.

Phylogenomic databases

eggNOGCOG0571.
HOGENOMHOG000246808.
KOK03685.
OMAYGFQEAR.
OrthoDBEOG6T1WVS.

Enzyme and pathway databases

BioCycMFLO265311:GHIB-252-MONOMER.

Family and domain databases

Gene3D1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPMF_00104. RNase_III.
InterProIPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERPTHR11207. PTHR11207. 1 hit.
PfamPF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
[Graphical view]
SMARTSM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMSSF69065. SSF69065. 1 hit.
TIGRFAMsTIGR02191. RNaseIII. 1 hit.
PROSITEPS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRNC_MESFL
AccessionPrimary (citable) accession number: Q6F1N5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: August 16, 2004
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families