Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Mesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1) (Acholeplasma florum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathway: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei276 – 2761Proton donorUniRule annotation
Active sitei297 – 2971UniRule annotation
Active sitei413 – 4131UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciMFLO265311:GHIB-275-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:Mfl254
OrganismiMesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1) (Acholeplasma florum)
Taxonomic identifieri265311 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesEntomoplasmatalesEntomoplasmataceaeMesoplasma
ProteomesiUP000006647 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Glucose-6-phosphate isomerasePRO_0000180671Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi265311.Mfl254.

Structurei

3D structure databases

ProteinModelPortaliQ6F1L2.
SMRiQ6F1L2. Positions 2-425.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000100403.
KOiK01810.
OMAiKYNMFKL.
OrthoDBiEOG64R61J.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6F1L2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKVDLQHSG LSIADLNEAK VKKVHEMIIN KSGKGNDFLG WIEWPKTFDK
60 70 80 90 100
KEYEEMKKVA SSLRNKIDVL VTVGIGGSYL GIRAADEMIR GINHSDKVQV
110 120 130 140 150
IYAGHTMSST YVAQLSEYLK GKKFGICVIS KSGTTTEPGI AFRALEKQLI
160 170 180 190 200
EQVGVEASKE LIVAVTDSSK GALKTLADNK GYPTFVIPDD IGGRFSVLTP
210 220 230 240 250
VGIFPLLVAG VNTDNIFAGA IKAMDELVQG DLTNEAYKYA AARNALYNAG
260 270 280 290 300
YKAEALVAYE LQMQYTAEWW KQLFGESEGK DNKGLYPTSM IFSTDLHSLG
310 320 330 340 350
QWVQEGARNV LFETVIKVKE PVANMLVEAD TDNYDGLNYL SGKSFHEINS
360 370 380 390 400
TAIEGVIDAH VNTGKMPNIV LEFDKMNDVQ FGYLVYFFEI AVAMSGYLLE
410 420
VNPFDQPGVE VYKYNMFKLL GKPGVK
Length:426
Mass (Da):47,034
Last modified:August 16, 2004 - v1
Checksum:i4E282927B6B145A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017263 Genomic DNA. Translation: AAT75611.1.
RefSeqiWP_011183151.1. NC_006055.1.
YP_053495.1. NC_006055.1.

Genome annotation databases

EnsemblBacteriaiAAT75611; AAT75611; Mfl254.
GeneIDi2897789.
KEGGimfl:Mfl254.
PATRICi22473235. VBIMesFlo3168_0254.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017263 Genomic DNA. Translation: AAT75611.1.
RefSeqiWP_011183151.1. NC_006055.1.
YP_053495.1. NC_006055.1.

3D structure databases

ProteinModelPortaliQ6F1L2.
SMRiQ6F1L2. Positions 2-425.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi265311.Mfl254.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT75611; AAT75611; Mfl254.
GeneIDi2897789.
KEGGimfl:Mfl254.
PATRICi22473235. VBIMesFlo3168_0254.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000100403.
KOiK01810.
OMAiKYNMFKL.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
BioCyciMFLO265311:GHIB-275-MONOMER.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33453 / NBRC 100688 / NCTC 11704 / L1.

Entry informationi

Entry nameiG6PI_MESFL
AccessioniPrimary (citable) accession number: Q6F1L2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: August 16, 2004
Last modified: April 1, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.