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Q6F145

- TYSY_MESFL

UniProt

Q6F145 - TYSY_MESFL

Protein

Thymidylate synthase

Gene

thyA

Organism
Mesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1) (Acholeplasma florum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Provides the sole de novo source of dTMP for DNA biosynthesis.UniRule annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei170 – 1701UniRule annotation

    GO - Molecular functioni

    1. thymidylate synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dTMP biosynthetic process Source: UniProtKB-HAMAP
    2. dTTP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciMFLO265311:GHIB-440-MONOMER.
    UniPathwayiUPA00575.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidylate synthaseUniRule annotation (EC:2.1.1.45UniRule annotation)
    Short name:
    TSUniRule annotation
    Short name:
    TSaseUniRule annotation
    Gene namesi
    Name:thyAUniRule annotation
    Ordered Locus Names:Mfl419
    OrganismiMesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1) (Acholeplasma florum)
    Taxonomic identifieri265311 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesEntomoplasmatalesEntomoplasmataceaeMesoplasma
    ProteomesiUP000006647: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288Thymidylate synthasePRO_0000140979Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi265311.Mfl419.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6F145.
    SMRiQ6F145. Positions 2-288.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0207.
    HOGENOMiHOG000257899.
    KOiK00560.
    OMAiDVHLYSN.
    OrthoDBiEOG6K6V53.

    Family and domain databases

    Gene3Di3.30.572.10. 1 hit.
    HAMAPiMF_00008. Thymidy_synth_bact.
    InterProiIPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    [Graphical view]
    PfamiPF00303. Thymidylat_synt. 1 hit.
    [Graphical view]
    PRINTSiPR00108. THYMDSNTHASE.
    SUPFAMiSSF55831. SSF55831. 1 hit.
    TIGRFAMsiTIGR03284. thym_sym. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6F145-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKQYLELVNE ILKDGEKRED RTNTGTISKF GVQKRYDLRE GFPLLTTKKV    50
    FYKAIFHEML WFIKGDTNIK YLVENNVKIW NEWPYENFKK SSEFNNETLQ 100
    EFVERLKNDN EFCNKWGDLG PVYGKQWRDF GGIDQFAKLI NDIKKNPFSR 150
    RHIVSAWNPA EVDNMLLPPC HSFWQVYVSK DGWLDLQLYQ RSGDVFLGVP 200
    FNIASYALLM ELIAKECNLK ARYFVHTIGD AHIYLNHLEQ INEQLKRKPL 250
    PLCKIKINSE KSIFDIAFED IEIEGYESHA KITGEVAV 288
    Length:288
    Mass (Da):33,889
    Last modified:August 16, 2004 - v1
    Checksum:i39CC3DBB87E6B46D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017263 Genomic DNA. Translation: AAT75778.1.
    RefSeqiYP_053662.1. NC_006055.1.

    Genome annotation databases

    EnsemblBacteriaiAAT75778; AAT75778; Mfl419.
    GeneIDi2897608.
    KEGGimfl:Mfl419.
    PATRICi22473585. VBIMesFlo3168_0420.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017263 Genomic DNA. Translation: AAT75778.1 .
    RefSeqi YP_053662.1. NC_006055.1.

    3D structure databases

    ProteinModelPortali Q6F145.
    SMRi Q6F145. Positions 2-288.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 265311.Mfl419.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAT75778 ; AAT75778 ; Mfl419 .
    GeneIDi 2897608.
    KEGGi mfl:Mfl419.
    PATRICi 22473585. VBIMesFlo3168_0420.

    Phylogenomic databases

    eggNOGi COG0207.
    HOGENOMi HOG000257899.
    KOi K00560.
    OMAi DVHLYSN.
    OrthoDBi EOG6K6V53.

    Enzyme and pathway databases

    UniPathwayi UPA00575 .
    BioCyci MFLO265311:GHIB-440-MONOMER.

    Family and domain databases

    Gene3Di 3.30.572.10. 1 hit.
    HAMAPi MF_00008. Thymidy_synth_bact.
    InterProi IPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    [Graphical view ]
    Pfami PF00303. Thymidylat_synt. 1 hit.
    [Graphical view ]
    PRINTSi PR00108. THYMDSNTHASE.
    SUPFAMi SSF55831. SSF55831. 1 hit.
    TIGRFAMsi TIGR03284. thym_sym. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33453 / NBRC 100688 / NCTC 11704 / L1.

    Entry informationi

    Entry nameiTYSY_MESFL
    AccessioniPrimary (citable) accession number: Q6F145
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3