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Q6F145

- TYSY_MESFL

UniProt

Q6F145 - TYSY_MESFL

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Protein

Thymidylate synthase

Gene

thyA

Organism
Mesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1) (Acholeplasma florum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Provides the sole de novo source of dTMP for DNA biosynthesis.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei170 – 1701UniRule annotation

GO - Molecular functioni

  1. thymidylate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dTMP biosynthetic process Source: UniProtKB-HAMAP
  2. dTTP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Enzyme and pathway databases

BioCyciMFLO265311:GHIB-440-MONOMER.
UniPathwayiUPA00575.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate synthaseUniRule annotation (EC:2.1.1.45UniRule annotation)
Short name:
TSUniRule annotation
Short name:
TSaseUniRule annotation
Gene namesi
Name:thyAUniRule annotation
Ordered Locus Names:Mfl419
OrganismiMesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1) (Acholeplasma florum)
Taxonomic identifieri265311 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesEntomoplasmatalesEntomoplasmataceaeMesoplasma
ProteomesiUP000006647: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Thymidylate synthasePRO_0000140979Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi265311.Mfl419.

Structurei

3D structure databases

ProteinModelPortaliQ6F145.
SMRiQ6F145. Positions 2-288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0207.
HOGENOMiHOG000257899.
KOiK00560.
OMAiDVHLYSN.
OrthoDBiEOG6K6V53.

Family and domain databases

Gene3Di3.30.572.10. 1 hit.
HAMAPiMF_00008. Thymidy_synth_bact.
InterProiIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
[Graphical view]
PfamiPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSiPR00108. THYMDSNTHASE.
SUPFAMiSSF55831. SSF55831. 1 hit.
TIGRFAMsiTIGR03284. thym_sym. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6F145-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKQYLELVNE ILKDGEKRED RTNTGTISKF GVQKRYDLRE GFPLLTTKKV
60 70 80 90 100
FYKAIFHEML WFIKGDTNIK YLVENNVKIW NEWPYENFKK SSEFNNETLQ
110 120 130 140 150
EFVERLKNDN EFCNKWGDLG PVYGKQWRDF GGIDQFAKLI NDIKKNPFSR
160 170 180 190 200
RHIVSAWNPA EVDNMLLPPC HSFWQVYVSK DGWLDLQLYQ RSGDVFLGVP
210 220 230 240 250
FNIASYALLM ELIAKECNLK ARYFVHTIGD AHIYLNHLEQ INEQLKRKPL
260 270 280
PLCKIKINSE KSIFDIAFED IEIEGYESHA KITGEVAV
Length:288
Mass (Da):33,889
Last modified:August 16, 2004 - v1
Checksum:i39CC3DBB87E6B46D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017263 Genomic DNA. Translation: AAT75778.1.
RefSeqiWP_011183318.1. NC_006055.1.
YP_053662.1. NC_006055.1.

Genome annotation databases

EnsemblBacteriaiAAT75778; AAT75778; Mfl419.
GeneIDi2897608.
KEGGimfl:Mfl419.
PATRICi22473585. VBIMesFlo3168_0420.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017263 Genomic DNA. Translation: AAT75778.1 .
RefSeqi WP_011183318.1. NC_006055.1.
YP_053662.1. NC_006055.1.

3D structure databases

ProteinModelPortali Q6F145.
SMRi Q6F145. Positions 2-288.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 265311.Mfl419.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT75778 ; AAT75778 ; Mfl419 .
GeneIDi 2897608.
KEGGi mfl:Mfl419.
PATRICi 22473585. VBIMesFlo3168_0420.

Phylogenomic databases

eggNOGi COG0207.
HOGENOMi HOG000257899.
KOi K00560.
OMAi DVHLYSN.
OrthoDBi EOG6K6V53.

Enzyme and pathway databases

UniPathwayi UPA00575 .
BioCyci MFLO265311:GHIB-440-MONOMER.

Family and domain databases

Gene3Di 3.30.572.10. 1 hit.
HAMAPi MF_00008. Thymidy_synth_bact.
InterProi IPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
[Graphical view ]
Pfami PF00303. Thymidylat_synt. 1 hit.
[Graphical view ]
PRINTSi PR00108. THYMDSNTHASE.
SUPFAMi SSF55831. SSF55831. 1 hit.
TIGRFAMsi TIGR03284. thym_sym. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33453 / NBRC 100688 / NCTC 11704 / L1.

Entry informationi

Entry nameiTYSY_MESFL
AccessioniPrimary (citable) accession number: Q6F145
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3