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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Mesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1) (Acholeplasma florum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei581ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMFLO265311:G1G0W-512-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Mfl490
OrganismiMesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1) (Acholeplasma florum)
Taxonomic identifieri265311 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesEntomoplasmatalesEntomoplasmataceaeMesoplasma
Proteomesi
  • UP000006647 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001520411 – 801Leucine--tRNA ligaseAdd BLAST801

Proteomic databases

PRIDEiQ6F0X5

Interactioni

Protein-protein interaction databases

STRINGi265311.Mfl490

Structurei

3D structure databases

ProteinModelPortaliQ6F0X5
SMRiQ6F0X5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi39 – 50"HIGH" regionAdd BLAST12
Motifi578 – 582"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q6F0X5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFSHKAIEK KWKKYWEENN TNKTTNTSDK KSYVLDMFPY PSGAGIHVGH
60 70 80 90 100
VKGYTATDVF SRYKRMNGYD VLHPMGWDAF GLPAEQYALK TGNDPIDFTL
110 120 130 140 150
ENIKTFKRQL KMMGFSYDFD KEISTANPNY YKITQWIFNQ LYKKGLAENR
160 170 180 190 200
DVEVNWCQEL GTVLANDEII EKDGLMVSER GEHPVTKRKM RQWVLKITEY
210 220 230 240 250
ADRLLEGLDE LEWNSSIKDL QRNWIGKSTG VELDFLVNNI KVPVFTTRID
260 270 280 290 300
TIYGVSYIVL APEHEQVLNI TTPEQLKEVQ TYIELAKNKS EIDRKDESKP
310 320 330 340 350
KTGVFTGSYA TNPHTNELVQ VWVSDYVLAN YGTGAVMAVP AHDKRDWEFA
360 370 380 390 400
TKFNLEKKFV IENKTDEKAF VGEGKIINSD ILNGMDKKQA IQTMTKIAIE
410 420 430 440 450
QGWGREQTNY KLRDWLFSRQ RFYGEPFPVL YGPNQEITLI EDLPVELPRI
460 470 480 490 500
KNIKPSGTGE SPLANVEEWV NVEIDGVKYR RETNTMPQSA GSSWYYLAYI
510 520 530 540 550
LADGENEFID IDSAEAKKRF EKWMPVDLYV GGQEHAVGHL LYARFWNYVL
560 570 580 590 600
YDLGITSVKE PFKQLFNQGM ILGPDGRKMS KSWGNVINPD DIVSTHGADS
610 620 630 640 650
LRLYEMFMGP LDASLPWSED GLDSALKWIH RAYRMVMTTE LTDVNDTKLD
660 670 680 690 700
FVYNDVVKNV SEMIESLKFN TAISQLMIFV NAVYKHEGPV YRPYIEGFVK
710 720 730 740 750
MLSIYAPFIG EELWEKLGHA PSITKQAWPV FDPSKLVSNT VVIALQINGK
760 770 780 790 800
LRATIEVEKG TIKDKLLELA KKQESIISYI KDKEIIKEIA VVDRIVNIVI

K
Length:801
Mass (Da):92,070
Last modified:August 16, 2004 - v1
Checksum:i7B12CCD8B1BCFFD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017263 Genomic DNA Translation: AAT75848.1
RefSeqiWP_011183388.1, NC_006055.1
YP_053732.1, NC_006055.1

Genome annotation databases

EnsemblBacteriaiAAT75848; AAT75848; Mfl490
GeneIDi2898120
KEGGimfl:Mfl490
PATRICifig|265311.5.peg.496

Similar proteinsi

Entry informationi

Entry nameiSYL_MESFL
AccessioniPrimary (citable) accession number: Q6F0X5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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