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Q6F0X5

- SYL_MESFL

UniProt

Q6F0X5 - SYL_MESFL

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Mesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1) (Acholeplasma florum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei581 – 5811ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMFLO265311:GHIB-510-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Mfl490
    OrganismiMesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1) (Acholeplasma florum)
    Taxonomic identifieri265311 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesEntomoplasmatalesEntomoplasmataceaeMesoplasma
    ProteomesiUP000006647: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 801801Leucine--tRNA ligasePRO_0000152041Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi265311.Mfl490.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6F0X5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi39 – 5012"HIGH" regionAdd
    BLAST
    Motifi578 – 5825"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 2 hits.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6F0X5-1 [UniParc]FASTAAdd to Basket

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    MEFSHKAIEK KWKKYWEENN TNKTTNTSDK KSYVLDMFPY PSGAGIHVGH    50
    VKGYTATDVF SRYKRMNGYD VLHPMGWDAF GLPAEQYALK TGNDPIDFTL 100
    ENIKTFKRQL KMMGFSYDFD KEISTANPNY YKITQWIFNQ LYKKGLAENR 150
    DVEVNWCQEL GTVLANDEII EKDGLMVSER GEHPVTKRKM RQWVLKITEY 200
    ADRLLEGLDE LEWNSSIKDL QRNWIGKSTG VELDFLVNNI KVPVFTTRID 250
    TIYGVSYIVL APEHEQVLNI TTPEQLKEVQ TYIELAKNKS EIDRKDESKP 300
    KTGVFTGSYA TNPHTNELVQ VWVSDYVLAN YGTGAVMAVP AHDKRDWEFA 350
    TKFNLEKKFV IENKTDEKAF VGEGKIINSD ILNGMDKKQA IQTMTKIAIE 400
    QGWGREQTNY KLRDWLFSRQ RFYGEPFPVL YGPNQEITLI EDLPVELPRI 450
    KNIKPSGTGE SPLANVEEWV NVEIDGVKYR RETNTMPQSA GSSWYYLAYI 500
    LADGENEFID IDSAEAKKRF EKWMPVDLYV GGQEHAVGHL LYARFWNYVL 550
    YDLGITSVKE PFKQLFNQGM ILGPDGRKMS KSWGNVINPD DIVSTHGADS 600
    LRLYEMFMGP LDASLPWSED GLDSALKWIH RAYRMVMTTE LTDVNDTKLD 650
    FVYNDVVKNV SEMIESLKFN TAISQLMIFV NAVYKHEGPV YRPYIEGFVK 700
    MLSIYAPFIG EELWEKLGHA PSITKQAWPV FDPSKLVSNT VVIALQINGK 750
    LRATIEVEKG TIKDKLLELA KKQESIISYI KDKEIIKEIA VVDRIVNIVI 800
    K 801
    Length:801
    Mass (Da):92,070
    Last modified:August 16, 2004 - v1
    Checksum:i7B12CCD8B1BCFFD5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017263 Genomic DNA. Translation: AAT75848.1.
    RefSeqiYP_053732.1. NC_006055.1.

    Genome annotation databases

    EnsemblBacteriaiAAT75848; AAT75848; Mfl490.
    GeneIDi2898120.
    KEGGimfl:Mfl490.
    PATRICi22473739. VBIMesFlo3168_0496.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017263 Genomic DNA. Translation: AAT75848.1 .
    RefSeqi YP_053732.1. NC_006055.1.

    3D structure databases

    ProteinModelPortali Q6F0X5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 265311.Mfl490.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAT75848 ; AAT75848 ; Mfl490 .
    GeneIDi 2898120.
    KEGGi mfl:Mfl490.
    PATRICi 22473739. VBIMesFlo3168_0496.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci MFLO265311:GHIB-510-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 2 hits.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33453 / NBRC 100688 / NCTC 11704 / L1.

    Entry informationi

    Entry nameiSYL_MESFL
    AccessioniPrimary (citable) accession number: Q6F0X5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3