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Q6F0R1 (SYR_MESFL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:Mfl554
OrganismMesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1) (Acholeplasma florum) [Reference proteome] [HAMAP]
Taxonomic identifier265311 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesEntomoplasmatalesEntomoplasmataceaeMesoplasma

Protein attributes

Sequence length553 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 553553Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000242042

Regions

Motif122 – 13211"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q6F0R1 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 754E92E79AF9C77E

FASTA55362,891
        10         20         30         40         50         60 
MENIISIVKK DLKEIAQKFN ISKDPIVEIN KNNIDSHFST TLALMSAKEL KQNPIQLAEN 

        70         80         90        100        110        120 
IKNELLQKDY YDQIEIAGPG FINIKLKTEL LSTTIKNITT LKEAYGKNKI KNKIINIEYV 

       130        140        150        160        170        180 
SANPTGFLHV GHARNAVTGS VLEEVLKFDG YEVQTEFYTN DAGNQINILA VTVFVHYLWA 

       190        200        210        220        230        240 
LGIETEKPAN TYGGTFYDDL ANIMIQKYGD KFKNLTFTET AISDEETHQI FRKEAVQHFL 

       250        260        270        280        290        300 
TEIKQQLKDF GVVIDHYSSE QEMYDTNQIE KLLKEYKEKN ATYEADGALW LKTTEFGDDK 

       310        320        330        340        350        360 
DRVLVKKDGS LTYIVPDLAT HNIRIQRTHA DVLINIWGGD HHGYIPRMRA GLQLLGHNPD 

       370        380        390        400        410        420 
ILEIEMVQMV RLIKDGKEYK MSKRKGTAVW LVDIMEMVGK DALRYMLASK SSSSHMDLDL 

       430        440        450        460        470        480 
DLVQQKNATN PVYYAQYATA RCHSILNQAD QKNIKANLNV SNLLSNKKEV ELLLTLDNFN 

       490        500        510        520        530        540 
QVIQMSAKNR APQLICEYIQ TVCKQFHSYY ADTKILDEND VPTSEARLGL VLSVLQVLTN 

       550 
AFNIIGVSAL ETM 

« Hide

References

[1]Birren B.W., Stange-Thomann N., Hafez N., DeCaprio D., Fisher S., Butler J., Elkins T., Kodira C.D., Major J., Wang S., Nicol R., Nusbaum C.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33453 / NBRC 100688 / NCTC 11704 / L1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017263 Genomic DNA. Translation: AAT75912.1.
RefSeqYP_053796.1. NC_006055.1.

3D structure databases

ProteinModelPortalQ6F0R1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING265311.Mfl554.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAT75912; AAT75912; Mfl554.
GeneID2897600.
KEGGmfl:Mfl554.
PATRIC22473889. VBIMesFlo3168_0559.

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247214.
KOK01887.
OMANPNGPLH.
OrthoDBEOG6JB13C.
ProtClustDBPRK01611.

Enzyme and pathway databases

BioCycMFLO265311:GHIB-574-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_MESFL
AccessionPrimary (citable) accession number: Q6F0R1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: August 16, 2004
Last modified: April 16, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries