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Q6F0I2

- KITH_MESFL

UniProt

Q6F0I2 - KITH_MESFL

Protein

Thymidine kinase

Gene

tdk

Organism
Mesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1) (Acholeplasma florum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei100 – 1001Proton acceptorUniRule annotation
    Metal bindingi156 – 1561ZincUniRule annotation
    Metal bindingi159 – 1591ZincUniRule annotation
    Metal bindingi194 – 1941ZincUniRule annotation
    Metal bindingi197 – 1971ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi21 – 288ATPUniRule annotation
    Nucleotide bindingi99 – 1024ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciMFLO265311:GHIB-653-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotation
    Ordered Locus Names:Mfl635
    OrganismiMesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1) (Acholeplasma florum)
    Taxonomic identifieri265311 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesEntomoplasmatalesEntomoplasmataceaeMesoplasma
    ProteomesiUP000006647: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 203203Thymidine kinasePRO_0000174992Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi265311.Mfl635.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6F0I2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1435.
    HOGENOMiHOG000076390.
    KOiK00857.
    OMAiQAICLSC.
    OrthoDBiEOG69D3J2.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6F0I2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIPNRDTIEQ KQLGWVELIT GCMFAGKTEE FIKRLRRHAF AKRNVIAFKP    50
    VIDTRYAVNE VASHAGTLLP SIPVNSTAEL KEKLEAKILE KKVDVVGIDE 100
    IQFFDEAIVD YIEELADRGI IVIVTGLDKD FRSQPFKNVD RILPLAEMVD 150
    KLTAICQKCG NFANRTQRII DGKPADWNSP LILVDGNDSY EARCRNCYQI 200
    EKG 203
    Length:203
    Mass (Da):22,998
    Last modified:August 16, 2004 - v1
    Checksum:iB4871C2CC2B2D487
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017263 Genomic DNA. Translation: AAT75991.1.
    RefSeqiYP_053875.1. NC_006055.1.

    Genome annotation databases

    EnsemblBacteriaiAAT75991; AAT75991; Mfl635.
    GeneIDi2897887.
    KEGGimfl:Mfl635.
    PATRICi22474049. VBIMesFlo3168_0637.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017263 Genomic DNA. Translation: AAT75991.1 .
    RefSeqi YP_053875.1. NC_006055.1.

    3D structure databases

    ProteinModelPortali Q6F0I2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 265311.Mfl635.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAT75991 ; AAT75991 ; Mfl635 .
    GeneIDi 2897887.
    KEGGi mfl:Mfl635.
    PATRICi 22474049. VBIMesFlo3168_0637.

    Phylogenomic databases

    eggNOGi COG1435.
    HOGENOMi HOG000076390.
    KOi K00857.
    OMAi QAICLSC.
    OrthoDBi EOG69D3J2.

    Enzyme and pathway databases

    BioCyci MFLO265311:GHIB-653-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33453 / NBRC 100688 / NCTC 11704 / L1.

    Entry informationi

    Entry nameiKITH_MESFL
    AccessioniPrimary (citable) accession number: Q6F0I2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3