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Protein

Phosphatidylinositol 4-phosphate 5-kinase 1

Gene

PIPK1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in flowering. May suppress floral initiation by modifying the expression of genes related to floral induction.1 Publication

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Transferase

Keywords - Biological processi

Differentiation, Flowering

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_319272. Synthesis of PIPs at the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 5-kinase 1 (EC:2.7.1.68)
Alternative name(s):
1-phosphatidylinositol 4-phosphate kinase
Diphosphoinositide kinase
PIP5K
PtdIns(4)P-5-kinase
Gene namesi
Name:PIPK1
Ordered Locus Names:Os03g0701800Imported, LOC_Os03g49510Imported
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
ProteomesiUP000000763 Componenti: Chromosome 3

Organism-specific databases

GrameneiQ6EX42.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 801780Phosphatidylinositol 4-phosphate 5-kinase 1PRO_0000024105Add
BLAST

Expressioni

Tissue specificityi

Expressed in young seedlings, shoot and seeds, and at lower level in roots, stem and leaf.1 Publication

Inductioni

By auxin, abscisic acid, cytokinins, gibberellic acid, Ca2+, methyl jasmonate and salicylic acid.1 Publication

Gene expression databases

ExpressionAtlasiQ6EX42. baseline.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os03g49510.1.

Structurei

3D structure databases

ProteinModelPortaliQ6EX42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati41 – 6323MORN 1Add
BLAST
Repeati64 – 8623MORN 2Add
BLAST
Repeati87 – 10923MORN 3Add
BLAST
Repeati110 – 13223MORN 4Add
BLAST
Repeati133 – 15523MORN 5Add
BLAST
Repeati156 – 17823MORN 6Add
BLAST
Repeati182 – 20120MORN 7Add
BLAST
Repeati202 – 22322MORN 8Add
BLAST
Domaini366 – 797432PIPKPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 8 MORN repeats.Curated
Contains 1 PIPK domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG4642.
HOGENOMiHOG000193875.
InParanoidiQ6EX42.
KOiK00889.
OMAiARIKMYF.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProiIPR003409. MORN.
IPR017163. PIno-4-P-5_kinase_pln.
IPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR016034. PInositol-4P-5-kinase_core_sub.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiPF02493. MORN. 8 hits.
PF01504. PIP5K. 1 hit.
[Graphical view]
PIRSFiPIRSF037274. PIP5K_plant_prd. 1 hit.
SMARTiSM00698. MORN. 8 hits.
SM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6EX42-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGLHVVSFL VVLLLQLRSS GMHLVASELF WGNTLPNGDI YVGSFDGLVP
60 70 80 90 100
HGPGKYMWTD GALYDGEWDK SKMTGRGLIQ WPSGASYEGD FRGGFIDGAG
110 120 130 140 150
TFKGVDGSVY KGSWRMNKKH GMGTMVYSNS DTYEGFWNEG LPDEFGKYTW
160 170 180 190 200
ADGNVYIGRW KSGKMNGSGV MQWINGDTLD CNWLNGLAHG KGYCKYASGA
210 220 230 240 250
CYIGTWDRGL KDGHGTFYQP GSKIPCNLEV SDCLTSHDGT SASSSSNEKI
260 270 280 290 300
TIGLLFLLQK LCKNWRLRRF LHRPRRISNG TTPVFDDNSG SHLCQDVSSK
310 320 330 340 350
SFSADDQCLQ DSEVDKDSVY EREYVQGVLI MEQPKNEDSR MSESGIAQEN
360 370 380 390 400
NWEKQAKGPM ETIYKGHRSY YLMLNLQLGI RYTVGKITPV PLREVRSNDF
410 420 430 440 450
GPRARIKMYF PCEGSQYTPP HYSVDFFWKD YCPMVFRNLR EMFHIDAADY
460 470 480 490 500
MMSICGGDSL KELSSPGKSG SIFYLSQDER FVIKTLRKTE LKIGLMKYVL
510 520 530 540 550
QILLKMLPKY YNHVKAYDNT LITKFFGVHR ITLKPGRKVR FVVMGNMFCT
560 570 580 590 600
ELRIHRKYDL KGSTQGRSTK KQNINENTTL KDLDLSYVFH VDKPWREALF
610 620 630 640 650
RQIALDCMFL ESQSIIDYSM LLGIHFRAPN HLKRITSCQN ALESTGISAE
660 670 680 690 700
TECSVALHHE ETISSKGFLL VAADEPGPAV RGSHIRGSMV RAAEGGYEEV
710 720 730 740 750
DLVLPGTGRF RVQLGVNMPA RARKVQEDVN VEVENRDTIE EYDVVLYLGI
760 770 780 790 800
IDILQEYNVS KRVEHAVKSL KFDPLSISAV DPNLYSRRFI SFLEKVFPEQ

D
Length:801
Mass (Da):90,680
Last modified:August 16, 2005 - v2
Checksum:iA72DED14A54CDCE6
GO
Isoform 2 (identifier: Q6EX42-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     494-502: Missing.

Note: May be due to intron retention. No experimental confirmation available.
Show »
Length:792
Mass (Da):89,634
Checksum:iC63D276B87126611
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei494 – 5029Missing in isoform 2. 1 PublicationVSP_015135

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ439082 mRNA. Translation: CAD27794.1.
AJ544688 mRNA. Translation: CAD67588.1.
AC091670 Genomic DNA. Translation: AAX95508.1.
DP000009 Genomic DNA. Translation: ABF98412.1.
AP008209 Genomic DNA. Translation: BAF12919.1.
RefSeqiNP_001051005.1. NM_001057540.1. [Q6EX42-2]
UniGeneiOs.38046.

Genome annotation databases

GeneIDi4333833.
KEGGiosa:4333833.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ439082 mRNA. Translation: CAD27794.1.
AJ544688 mRNA. Translation: CAD67588.1.
AC091670 Genomic DNA. Translation: AAX95508.1.
DP000009 Genomic DNA. Translation: ABF98412.1.
AP008209 Genomic DNA. Translation: BAF12919.1.
RefSeqiNP_001051005.1. NM_001057540.1. [Q6EX42-2]
UniGeneiOs.38046.

3D structure databases

ProteinModelPortaliQ6EX42.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os03g49510.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4333833.
KEGGiosa:4333833.

Organism-specific databases

GrameneiQ6EX42.

Phylogenomic databases

eggNOGiCOG4642.
HOGENOMiHOG000193875.
InParanoidiQ6EX42.
KOiK00889.
OMAiARIKMYF.

Enzyme and pathway databases

ReactomeiREACT_319272. Synthesis of PIPs at the plasma membrane.

Gene expression databases

ExpressionAtlasiQ6EX42. baseline.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProiIPR003409. MORN.
IPR017163. PIno-4-P-5_kinase_pln.
IPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR016034. PInositol-4P-5-kinase_core_sub.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiPF02493. MORN. 8 hits.
PF01504. PIP5K. 1 hit.
[Graphical view]
PIRSFiPIRSF037274. PIP5K_plant_prd. 1 hit.
SMARTiSM00698. MORN. 8 hits.
SM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "OsPIPK 1, a rice phosphatidylinositol monophosphate kinase, regulates rice heading by modifying the expression of floral induction genes."
    Ma H., Xu S.-P., Luo D., Xu Z.-H., Xue H.-W.
    Plant Mol. Biol. 54:295-310(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [MRNA] OF 112-801 (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, INDUCTION.
    Strain: cv. Zhonghua 11.
  2. "Sequence, annotation, and analysis of synteny between rice chromosome 3 and diverged grass species."
    The rice chromosome 3 sequencing consortium
    Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B., Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T., Fadrosh D., Bera J., Weaver B., Jin S.
    , Johri S., Reardon M., Webb K., Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T., Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R., Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J., Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S., Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M., Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M., Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L., O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R., Jin W., Lee H.R., Jiang J., Jackson S.
    Genome Res. 15:1284-1291(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  4. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiPI5K1_ORYSJ
AccessioniPrimary (citable) accession number: Q6EX42
Secondary accession number(s): Q10ED0, Q70Z13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: July 22, 2015
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Transgenic plants suppressing PIPK1 show earlier heading (7 to 14 days earlier), delayed leaf development (a common phenotype observed with earlier flowering), and greater expression of floral induction genes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.