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Q6EX42

- PI5K1_ORYSJ

UniProt

Q6EX42 - PI5K1_ORYSJ

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Protein

Phosphatidylinositol 4-phosphate 5-kinase 1

Gene
PIPK1, Os03g0701800, LOC_Os03g49510
Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in flowering. May suppress floral initiation by modifying the expression of genes related to floral induction.1 Publication

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

  1. 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. flower development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Transferase

Keywords - Biological processi

Differentiation, Flowering

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_215617. Synthesis of PIPs at the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 5-kinase 1 (EC:2.7.1.68)
Alternative name(s):
1-phosphatidylinositol 4-phosphate kinase
Diphosphoinositide kinase
PIP5K
PtdIns(4)P-5-kinase
Gene namesi
Name:PIPK1
Ordered Locus Names:Os03g0701800, LOC_Os03g49510
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 3

Organism-specific databases

GrameneiQ6EX42.

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: EnsemblPlants/Gramene
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 801780Phosphatidylinositol 4-phosphate 5-kinase 1PRO_0000024105Add
BLAST

Expressioni

Tissue specificityi

Expressed in young seedlings, shoot and seeds, and at lower level in roots, stem and leaf.1 Publication

Inductioni

By auxin, abscisic acid, cytokinins, gibberellic acid, Ca2+, methyl jasmonate and salicylic acid.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ6EX42.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati41 – 6323MORN 1Add
BLAST
Repeati64 – 8623MORN 2Add
BLAST
Repeati87 – 10923MORN 3Add
BLAST
Repeati110 – 13223MORN 4Add
BLAST
Repeati133 – 15523MORN 5Add
BLAST
Repeati156 – 17823MORN 6Add
BLAST
Repeati182 – 20120MORN 7Add
BLAST
Repeati202 – 22322MORN 8Add
BLAST
Domaini366 – 797432PIPKAdd
BLAST

Sequence similaritiesi

Contains 8 MORN repeats.
Contains 1 PIPK domain.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG4642.
HOGENOMiHOG000193875.
KOiK00889.
OMAiMERISEC.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProiIPR003409. MORN.
IPR017163. PIno-4-P-5_kinase_pln.
IPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR016034. PInositol-4P-5-kinase_core_sub.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiPF02493. MORN. 8 hits.
PF01504. PIP5K. 1 hit.
[Graphical view]
PIRSFiPIRSF037274. PIP5K_plant_prd. 1 hit.
SMARTiSM00698. MORN. 8 hits.
SM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6EX42-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPGLHVVSFL VVLLLQLRSS GMHLVASELF WGNTLPNGDI YVGSFDGLVP    50
HGPGKYMWTD GALYDGEWDK SKMTGRGLIQ WPSGASYEGD FRGGFIDGAG 100
TFKGVDGSVY KGSWRMNKKH GMGTMVYSNS DTYEGFWNEG LPDEFGKYTW 150
ADGNVYIGRW KSGKMNGSGV MQWINGDTLD CNWLNGLAHG KGYCKYASGA 200
CYIGTWDRGL KDGHGTFYQP GSKIPCNLEV SDCLTSHDGT SASSSSNEKI 250
TIGLLFLLQK LCKNWRLRRF LHRPRRISNG TTPVFDDNSG SHLCQDVSSK 300
SFSADDQCLQ DSEVDKDSVY EREYVQGVLI MEQPKNEDSR MSESGIAQEN 350
NWEKQAKGPM ETIYKGHRSY YLMLNLQLGI RYTVGKITPV PLREVRSNDF 400
GPRARIKMYF PCEGSQYTPP HYSVDFFWKD YCPMVFRNLR EMFHIDAADY 450
MMSICGGDSL KELSSPGKSG SIFYLSQDER FVIKTLRKTE LKIGLMKYVL 500
QILLKMLPKY YNHVKAYDNT LITKFFGVHR ITLKPGRKVR FVVMGNMFCT 550
ELRIHRKYDL KGSTQGRSTK KQNINENTTL KDLDLSYVFH VDKPWREALF 600
RQIALDCMFL ESQSIIDYSM LLGIHFRAPN HLKRITSCQN ALESTGISAE 650
TECSVALHHE ETISSKGFLL VAADEPGPAV RGSHIRGSMV RAAEGGYEEV 700
DLVLPGTGRF RVQLGVNMPA RARKVQEDVN VEVENRDTIE EYDVVLYLGI 750
IDILQEYNVS KRVEHAVKSL KFDPLSISAV DPNLYSRRFI SFLEKVFPEQ 800
D 801
Length:801
Mass (Da):90,680
Last modified:August 16, 2005 - v2
Checksum:iA72DED14A54CDCE6
GO
Isoform 2 (identifier: Q6EX42-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     494-502: Missing.

Note: May be due to intron retention. No experimental confirmation available.

Show »
Length:792
Mass (Da):89,634
Checksum:iC63D276B87126611
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei494 – 5029Missing in isoform 2. VSP_015135

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ439082 mRNA. Translation: CAD27794.1.
AJ544688 mRNA. Translation: CAD67588.1.
AC091670 Genomic DNA. Translation: AAX95508.1.
RefSeqiNP_001051005.1. NM_001057540.1. [Q6EX42-2]
UniGeneiOs.38046.

Genome annotation databases

GeneIDi4333833.
KEGGiosa:4333833.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ439082 mRNA. Translation: CAD27794.1 .
AJ544688 mRNA. Translation: CAD67588.1 .
AC091670 Genomic DNA. Translation: AAX95508.1 .
RefSeqi NP_001051005.1. NM_001057540.1. [Q6EX42-2 ]
UniGenei Os.38046.

3D structure databases

ProteinModelPortali Q6EX42.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4333833.
KEGGi osa:4333833.

Organism-specific databases

Gramenei Q6EX42.

Phylogenomic databases

eggNOGi COG4642.
HOGENOMi HOG000193875.
KOi K00889.
OMAi MERISEC.

Enzyme and pathway databases

Reactomei REACT_215617. Synthesis of PIPs at the plasma membrane.

Family and domain databases

Gene3Di 3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProi IPR003409. MORN.
IPR017163. PIno-4-P-5_kinase_pln.
IPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR016034. PInositol-4P-5-kinase_core_sub.
[Graphical view ]
PANTHERi PTHR23086. PTHR23086. 1 hit.
Pfami PF02493. MORN. 8 hits.
PF01504. PIP5K. 1 hit.
[Graphical view ]
PIRSFi PIRSF037274. PIP5K_plant_prd. 1 hit.
SMARTi SM00698. MORN. 8 hits.
SM00330. PIPKc. 1 hit.
[Graphical view ]
PROSITEi PS51455. PIPK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "OsPIPK 1, a rice phosphatidylinositol monophosphate kinase, regulates rice heading by modifying the expression of floral induction genes."
    Ma H., Xu S.-P., Luo D., Xu Z.-H., Xue H.-W.
    Plant Mol. Biol. 54:295-310(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [MRNA] OF 112-801 (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, INDUCTION.
    Strain: cv. Zhonghua 11.
  2. "Sequence, annotation, and analysis of synteny between rice chromosome 3 and diverged grass species."
    The rice chromosome 3 sequencing consortium
    Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B., Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T., Fadrosh D., Bera J., Weaver B., Jin S.
    , Johri S., Reardon M., Webb K., Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T., Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R., Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J., Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S., Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M., Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M., Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L., O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R., Jin W., Lee H.R., Jiang J., Jackson S.
    Genome Res. 15:1284-1291(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiPI5K1_ORYSJ
AccessioniPrimary (citable) accession number: Q6EX42
Secondary accession number(s): Q70Z13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: September 3, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Transgenic plants suppressing PIPK1 show earlier heading (7 to 14 days earlier), delayed leaf development (a common phenotype observed with earlier flowering), and greater expression of floral induction genes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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