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Q6EX42

- PI5K1_ORYSJ

UniProt

Q6EX42 - PI5K1_ORYSJ

Protein

Phosphatidylinositol 4-phosphate 5-kinase 1

Gene

PIPK1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 2 (16 Aug 2005)
      Previous versions | rss
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    Functioni

    Involved in flowering. May suppress floral initiation by modifying the expression of genes related to floral induction.1 Publication

    Catalytic activityi

    ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

    GO - Molecular functioni

    1. 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. flower development Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein, Kinase, Transferase

    Keywords - Biological processi

    Differentiation, Flowering

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_215617. Synthesis of PIPs at the plasma membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol 4-phosphate 5-kinase 1 (EC:2.7.1.68)
    Alternative name(s):
    1-phosphatidylinositol 4-phosphate kinase
    Diphosphoinositide kinase
    PIP5K
    PtdIns(4)P-5-kinase
    Gene namesi
    Name:PIPK1
    Ordered Locus Names:Os03g0701800, LOC_Os03g49510
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 3

    Organism-specific databases

    GrameneiQ6EX42.

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: EnsemblPlants/Gramene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 801780Phosphatidylinositol 4-phosphate 5-kinase 1PRO_0000024105Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed in young seedlings, shoot and seeds, and at lower level in roots, stem and leaf.1 Publication

    Inductioni

    By auxin, abscisic acid, cytokinins, gibberellic acid, Ca2+, methyl jasmonate and salicylic acid.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ6EX42.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati41 – 6323MORN 1Add
    BLAST
    Repeati64 – 8623MORN 2Add
    BLAST
    Repeati87 – 10923MORN 3Add
    BLAST
    Repeati110 – 13223MORN 4Add
    BLAST
    Repeati133 – 15523MORN 5Add
    BLAST
    Repeati156 – 17823MORN 6Add
    BLAST
    Repeati182 – 20120MORN 7Add
    BLAST
    Repeati202 – 22322MORN 8Add
    BLAST
    Domaini366 – 797432PIPKPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 8 MORN repeats.Curated
    Contains 1 PIPK domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG4642.
    HOGENOMiHOG000193875.
    KOiK00889.
    OMAiMERISEC.

    Family and domain databases

    Gene3Di3.30.800.10. 1 hit.
    3.30.810.10. 2 hits.
    InterProiIPR003409. MORN.
    IPR017163. PIno-4-P-5_kinase_pln.
    IPR023610. PInositol-4-P-5-kinase.
    IPR027483. PInositol-4-P-5-kinase_C.
    IPR002498. PInositol-4-P-5-kinase_core.
    IPR027484. PInositol-4-P-5-kinase_N.
    IPR016034. PInositol-4P-5-kinase_core_sub.
    [Graphical view]
    PANTHERiPTHR23086. PTHR23086. 1 hit.
    PfamiPF02493. MORN. 8 hits.
    PF01504. PIP5K. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037274. PIP5K_plant_prd. 1 hit.
    SMARTiSM00698. MORN. 8 hits.
    SM00330. PIPKc. 1 hit.
    [Graphical view]
    PROSITEiPS51455. PIPK. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6EX42-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPGLHVVSFL VVLLLQLRSS GMHLVASELF WGNTLPNGDI YVGSFDGLVP    50
    HGPGKYMWTD GALYDGEWDK SKMTGRGLIQ WPSGASYEGD FRGGFIDGAG 100
    TFKGVDGSVY KGSWRMNKKH GMGTMVYSNS DTYEGFWNEG LPDEFGKYTW 150
    ADGNVYIGRW KSGKMNGSGV MQWINGDTLD CNWLNGLAHG KGYCKYASGA 200
    CYIGTWDRGL KDGHGTFYQP GSKIPCNLEV SDCLTSHDGT SASSSSNEKI 250
    TIGLLFLLQK LCKNWRLRRF LHRPRRISNG TTPVFDDNSG SHLCQDVSSK 300
    SFSADDQCLQ DSEVDKDSVY EREYVQGVLI MEQPKNEDSR MSESGIAQEN 350
    NWEKQAKGPM ETIYKGHRSY YLMLNLQLGI RYTVGKITPV PLREVRSNDF 400
    GPRARIKMYF PCEGSQYTPP HYSVDFFWKD YCPMVFRNLR EMFHIDAADY 450
    MMSICGGDSL KELSSPGKSG SIFYLSQDER FVIKTLRKTE LKIGLMKYVL 500
    QILLKMLPKY YNHVKAYDNT LITKFFGVHR ITLKPGRKVR FVVMGNMFCT 550
    ELRIHRKYDL KGSTQGRSTK KQNINENTTL KDLDLSYVFH VDKPWREALF 600
    RQIALDCMFL ESQSIIDYSM LLGIHFRAPN HLKRITSCQN ALESTGISAE 650
    TECSVALHHE ETISSKGFLL VAADEPGPAV RGSHIRGSMV RAAEGGYEEV 700
    DLVLPGTGRF RVQLGVNMPA RARKVQEDVN VEVENRDTIE EYDVVLYLGI 750
    IDILQEYNVS KRVEHAVKSL KFDPLSISAV DPNLYSRRFI SFLEKVFPEQ 800
    D 801
    Length:801
    Mass (Da):90,680
    Last modified:August 16, 2005 - v2
    Checksum:iA72DED14A54CDCE6
    GO
    Isoform 2 (identifier: Q6EX42-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         494-502: Missing.

    Note: May be due to intron retention. No experimental confirmation available.

    Show »
    Length:792
    Mass (Da):89,634
    Checksum:iC63D276B87126611
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei494 – 5029Missing in isoform 2. 1 PublicationVSP_015135

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ439082 mRNA. Translation: CAD27794.1.
    AJ544688 mRNA. Translation: CAD67588.1.
    AC091670 Genomic DNA. Translation: AAX95508.1.
    RefSeqiNP_001051005.1. NM_001057540.1. [Q6EX42-2]
    UniGeneiOs.38046.

    Genome annotation databases

    GeneIDi4333833.
    KEGGiosa:4333833.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ439082 mRNA. Translation: CAD27794.1 .
    AJ544688 mRNA. Translation: CAD67588.1 .
    AC091670 Genomic DNA. Translation: AAX95508.1 .
    RefSeqi NP_001051005.1. NM_001057540.1. [Q6EX42-2 ]
    UniGenei Os.38046.

    3D structure databases

    ProteinModelPortali Q6EX42.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4333833.
    KEGGi osa:4333833.

    Organism-specific databases

    Gramenei Q6EX42.

    Phylogenomic databases

    eggNOGi COG4642.
    HOGENOMi HOG000193875.
    KOi K00889.
    OMAi MERISEC.

    Enzyme and pathway databases

    Reactomei REACT_215617. Synthesis of PIPs at the plasma membrane.

    Family and domain databases

    Gene3Di 3.30.800.10. 1 hit.
    3.30.810.10. 2 hits.
    InterProi IPR003409. MORN.
    IPR017163. PIno-4-P-5_kinase_pln.
    IPR023610. PInositol-4-P-5-kinase.
    IPR027483. PInositol-4-P-5-kinase_C.
    IPR002498. PInositol-4-P-5-kinase_core.
    IPR027484. PInositol-4-P-5-kinase_N.
    IPR016034. PInositol-4P-5-kinase_core_sub.
    [Graphical view ]
    PANTHERi PTHR23086. PTHR23086. 1 hit.
    Pfami PF02493. MORN. 8 hits.
    PF01504. PIP5K. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037274. PIP5K_plant_prd. 1 hit.
    SMARTi SM00698. MORN. 8 hits.
    SM00330. PIPKc. 1 hit.
    [Graphical view ]
    PROSITEi PS51455. PIPK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "OsPIPK 1, a rice phosphatidylinositol monophosphate kinase, regulates rice heading by modifying the expression of floral induction genes."
      Ma H., Xu S.-P., Luo D., Xu Z.-H., Xue H.-W.
      Plant Mol. Biol. 54:295-310(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [MRNA] OF 112-801 (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, INDUCTION.
      Strain: cv. Zhonghua 11.
    2. "Sequence, annotation, and analysis of synteny between rice chromosome 3 and diverged grass species."
      The rice chromosome 3 sequencing consortium
      Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B., Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T., Fadrosh D., Bera J., Weaver B., Jin S.
      , Johri S., Reardon M., Webb K., Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T., Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R., Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J., Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S., Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M., Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M., Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L., O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R., Jin W., Lee H.R., Jiang J., Jackson S.
      Genome Res. 15:1284-1291(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiPI5K1_ORYSJ
    AccessioniPrimary (citable) accession number: Q6EX42
    Secondary accession number(s): Q70Z13
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: August 16, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Transgenic plants suppressing PIPK1 show earlier heading (7 to 14 days earlier), delayed leaf development (a common phenotype observed with earlier flowering), and greater expression of floral induction genes.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3