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Protein

Phosphatidylinositol 4-phosphate 5-kinase 1

Gene

PIPK1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in flowering. May suppress floral initiation by modifying the expression of genes related to floral induction.1 Publication

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Transferase

Keywords - Biological processi

Differentiation, Flowering

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-OSA-1660499. Synthesis of PIPs at the plasma membrane.
R-OSA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-OSA-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 5-kinase 1 (EC:2.7.1.68)
Alternative name(s):
1-phosphatidylinositol 4-phosphate kinase
Diphosphoinositide kinase
PIP5K
PtdIns(4)P-5-kinase
Gene namesi
Name:PIPK1
Ordered Locus Names:Os03g0701800Imported, LOC_Os03g49510Imported
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
Proteomesi
  • UP000059680 Componenti: Chromosome 3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002410522 – 801Phosphatidylinositol 4-phosphate 5-kinase 1Add BLAST780

Proteomic databases

PaxDbiQ6EX42.

Expressioni

Tissue specificityi

Expressed in young seedlings, shoot and seeds, and at lower level in roots, stem and leaf.1 Publication

Inductioni

By auxin, abscisic acid, cytokinins, gibberellic acid, Ca2+, methyl jasmonate and salicylic acid.1 Publication

Gene expression databases

GenevisibleiQ6EX42. OS.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os03g49510.1.

Structurei

3D structure databases

ProteinModelPortaliQ6EX42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati41 – 63MORN 1Add BLAST23
Repeati64 – 86MORN 2Add BLAST23
Repeati87 – 109MORN 3Add BLAST23
Repeati110 – 132MORN 4Add BLAST23
Repeati133 – 155MORN 5Add BLAST23
Repeati156 – 178MORN 6Add BLAST23
Repeati182 – 201MORN 7Add BLAST20
Repeati202 – 223MORN 8Add BLAST22
Domaini366 – 797PIPKPROSITE-ProRule annotationAdd BLAST432

Sequence similaritiesi

Contains 8 MORN repeats.Curated
Contains 1 PIPK domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG0229. Eukaryota.
COG4642. LUCA.
COG5253. LUCA.
HOGENOMiHOG000193875.
InParanoidiQ6EX42.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProiIPR003409. MORN.
IPR017163. PIno-4-P-5_kinase_pln.
IPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 2 hits.
PfamiPF02493. MORN. 8 hits.
PF01504. PIP5K. 1 hit.
[Graphical view]
PIRSFiPIRSF037274. PIP5K_plant_prd. 1 hit.
SMARTiSM00698. MORN. 8 hits.
SM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6EX42-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGLHVVSFL VVLLLQLRSS GMHLVASELF WGNTLPNGDI YVGSFDGLVP
60 70 80 90 100
HGPGKYMWTD GALYDGEWDK SKMTGRGLIQ WPSGASYEGD FRGGFIDGAG
110 120 130 140 150
TFKGVDGSVY KGSWRMNKKH GMGTMVYSNS DTYEGFWNEG LPDEFGKYTW
160 170 180 190 200
ADGNVYIGRW KSGKMNGSGV MQWINGDTLD CNWLNGLAHG KGYCKYASGA
210 220 230 240 250
CYIGTWDRGL KDGHGTFYQP GSKIPCNLEV SDCLTSHDGT SASSSSNEKI
260 270 280 290 300
TIGLLFLLQK LCKNWRLRRF LHRPRRISNG TTPVFDDNSG SHLCQDVSSK
310 320 330 340 350
SFSADDQCLQ DSEVDKDSVY EREYVQGVLI MEQPKNEDSR MSESGIAQEN
360 370 380 390 400
NWEKQAKGPM ETIYKGHRSY YLMLNLQLGI RYTVGKITPV PLREVRSNDF
410 420 430 440 450
GPRARIKMYF PCEGSQYTPP HYSVDFFWKD YCPMVFRNLR EMFHIDAADY
460 470 480 490 500
MMSICGGDSL KELSSPGKSG SIFYLSQDER FVIKTLRKTE LKIGLMKYVL
510 520 530 540 550
QILLKMLPKY YNHVKAYDNT LITKFFGVHR ITLKPGRKVR FVVMGNMFCT
560 570 580 590 600
ELRIHRKYDL KGSTQGRSTK KQNINENTTL KDLDLSYVFH VDKPWREALF
610 620 630 640 650
RQIALDCMFL ESQSIIDYSM LLGIHFRAPN HLKRITSCQN ALESTGISAE
660 670 680 690 700
TECSVALHHE ETISSKGFLL VAADEPGPAV RGSHIRGSMV RAAEGGYEEV
710 720 730 740 750
DLVLPGTGRF RVQLGVNMPA RARKVQEDVN VEVENRDTIE EYDVVLYLGI
760 770 780 790 800
IDILQEYNVS KRVEHAVKSL KFDPLSISAV DPNLYSRRFI SFLEKVFPEQ

D
Length:801
Mass (Da):90,680
Last modified:August 16, 2005 - v2
Checksum:iA72DED14A54CDCE6
GO
Isoform 2 (identifier: Q6EX42-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     494-502: Missing.

Note: May be due to intron retention. No experimental confirmation available.
Show »
Length:792
Mass (Da):89,634
Checksum:iC63D276B87126611
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015135494 – 502Missing in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ439082 mRNA. Translation: CAD27794.1.
AJ544688 mRNA. Translation: CAD67588.1.
AC091670 Genomic DNA. Translation: AAX95508.1.
DP000009 Genomic DNA. Translation: ABF98412.1.
AP008209 Genomic DNA. Translation: BAF12919.1.
AP014959 Genomic DNA. No translation available.
UniGeneiOs.38046.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ439082 mRNA. Translation: CAD27794.1.
AJ544688 mRNA. Translation: CAD67588.1.
AC091670 Genomic DNA. Translation: AAX95508.1.
DP000009 Genomic DNA. Translation: ABF98412.1.
AP008209 Genomic DNA. Translation: BAF12919.1.
AP014959 Genomic DNA. No translation available.
UniGeneiOs.38046.

3D structure databases

ProteinModelPortaliQ6EX42.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os03g49510.1.

Proteomic databases

PaxDbiQ6EX42.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0229. Eukaryota.
COG4642. LUCA.
COG5253. LUCA.
HOGENOMiHOG000193875.
InParanoidiQ6EX42.

Enzyme and pathway databases

ReactomeiR-OSA-1660499. Synthesis of PIPs at the plasma membrane.
R-OSA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-OSA-8856828. Clathrin-mediated endocytosis.

Gene expression databases

GenevisibleiQ6EX42. OS.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProiIPR003409. MORN.
IPR017163. PIno-4-P-5_kinase_pln.
IPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 2 hits.
PfamiPF02493. MORN. 8 hits.
PF01504. PIP5K. 1 hit.
[Graphical view]
PIRSFiPIRSF037274. PIP5K_plant_prd. 1 hit.
SMARTiSM00698. MORN. 8 hits.
SM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPI5K1_ORYSJ
AccessioniPrimary (citable) accession number: Q6EX42
Secondary accession number(s): Q10ED0, Q70Z13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: October 5, 2016
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Transgenic plants suppressing PIPK1 show earlier heading (7 to 14 days earlier), delayed leaf development (a common phenotype observed with earlier flowering), and greater expression of floral induction genes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.