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Protein
Submitted name:

Neuronal nicotinic acetylcholine receptor, alpha5 subunit

Gene

CHRNA5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Neuronal nicotinic acetylcholine receptor, alpha5 subunitImported
Gene namesi
Name:CHRNA5Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 41HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSG00000169684.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000299565.

Structurei

3D structure databases

ProteinModelPortaliQ6EWN4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 36Neur_chan_membInterPro annotationAdd BLAST34

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
KOiK04807.

Family and domain databases

Gene3Di1.20.120.370. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02932. Neur_chan_memb. 1 hit.
[Graphical view]
SUPFAMiSSF90112. SSF90112. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q6EWN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DVREVVEDWK FIAQVLDRMF LWTFLFVSIV GSLGLFVPVI YKWANILIPV

HIGNANK
Length:57
Mass (Da):6,619
Last modified:August 16, 2004 - v1
Checksum:i36E995660FD2C213
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ584705 mRNA. Translation: CAE48367.1.
AJ584706 mRNA. Translation: CAE48368.1.
RefSeqiNP_000736.2. NM_000745.3.
NP_001294874.1. NM_001307945.1.
UniGeneiHs.1614.
Hs.719767.

Genome annotation databases

GeneIDi1138.
KEGGihsa:1138.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ584705 mRNA. Translation: CAE48367.1.
AJ584706 mRNA. Translation: CAE48368.1.
RefSeqiNP_000736.2. NM_000745.3.
NP_001294874.1. NM_001307945.1.
UniGeneiHs.1614.
Hs.719767.

3D structure databases

ProteinModelPortaliQ6EWN4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000299565.

Protocols and materials databases

DNASUi1138.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1138.
KEGGihsa:1138.

Organism-specific databases

CTDi1138.

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
KOiK04807.

Miscellaneous databases

GenomeRNAii1138.

Gene expression databases

BgeeiENSG00000169684.

Family and domain databases

Gene3Di1.20.120.370. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02932. Neur_chan_memb. 1 hit.
[Graphical view]
SUPFAMiSSF90112. SSF90112. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6EWN4_HUMAN
AccessioniPrimary (citable) accession number: Q6EWN4
Entry historyi
Integrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 2, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.