ID   Q6EVB8_PAVHB            Unreviewed;       666 AA.
AC   Q6EVB8;
DT   16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT   16-AUG-2004, sequence version 1.
DT   27-MAR-2024, entry version 65.
DE   SubName: Full=Non-structural protein {ECO:0000313|EMBL:CAG70323.1};
DE   Flags: Fragment;
GN   Name=ns {ECO:0000313|EMBL:CAG70323.1};
OS   Human parvovirus B19 (HPV B19).
OC   Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Quintoviricetes;
OC   Piccovirales; Parvoviridae; Parvovirinae; Erythroparvovirus;
OC   Erythroparvovirus primate1.
OX   NCBI_TaxID=10798 {ECO:0000313|EMBL:CAG70323.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:CAG70323.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=3 {ECO:0000313|EMBL:CAG70323.1};
RX   PubMed=15288608; DOI=10.1016/j.jcv.2004.05.015;
RA   Plentz A., Hahn J., Holler E., Jilg W., Modrow S.;
RT   "Long-term parvovirus B19 viraemia associated with pure red cell aplasia
RT   after allogeneic bone marrow transplantation.";
RL   J. Clin. Virol. 31:16-19(2004).
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000256|ARBA:ARBA00004147}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; AJ781033; CAG70323.1; -; Genomic_DNA.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0019079; P:viral genome replication; IEA:InterPro.
DR   Gene3D; 3.40.1310.20; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR014015; Helicase_SF3_DNA-vir.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001257; Parvovirus_NS1_helicase.
DR   InterPro; IPR014835; Rep_N.
DR   Pfam; PF01057; Parvo_NS1; 1.
DR   Pfam; PF08724; Rep_N; 1.
DR   SUPFAM; SSF55464; Origin of replication-binding domain, RBD-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51206; SF3_HELICASE_1; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   Host nucleus {ECO:0000256|ARBA:ARBA00022562};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840}.
FT   DOMAIN          297..452
FT                   /note="SF3 helicase"
FT                   /evidence="ECO:0000259|PROSITE:PS51206"
FT   REGION          527..549
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:CAG70323.1"
SQ   SEQUENCE   666 AA;  73442 MW;  62CBD899176773D8 CRC64;
     GVLQISSNVL DCANDNWWCS LLDLDTSDWE PLTHTNRLMA IYLSSVASKL DFTGGPLAGC
     LYFFQVECNK FEEGYHIHVV IGGPGLNPRN LTVCVEGLFN NVLYHLVTGN VKLKFLPGMT
     TKGKYFRDGE QFIENYLMKK IPLNVVWCVT NIDGYIDTCI SATFRRGACH AKKPRMTTAI
     NDTSSDAGES SGTGAEVVPF NGKGTKASIK FQTMVNWLCE NRVFTEDKWK LVDFNQYTLL
     SSSHSGSFQI QSALKLAIYK ATNLVPTSTF LLHTDFEQVM CIKDNKIVKL LLCQNYDPLL
     VGQHVLKWID KKCGKKNTLW FYGPPSTGKT NLAMAIAKSV PVYGMVNWNN ENFPFNDVAG
     KSLVVWDEGI IKSTIVEAAK AILGGQPTRV DQKMRGSVAV PGVPVVITSN GDITFVVSGN
     TTTTVHAKAL KERMVKLNFT VRCSPDMGLL TEADVQQWLT WCNAQSWDHY ENWAIYYTFD
     FPGINADALH PDLQTTPIVT DTSISSSGGE SSEELSESSF FNLITPGAWN TETPRSSTPI
     PGTSSGESFV GSPVSSEVVA ASWEEAFYTP LADQFRELLV GVDYVWDGVR GLPVCCVQHI
     NNSGGGLGLC PHCINVGAWY NGWKFREFTP DLVRCSCHVG ASNPFSVLTC KKCAYLSGLQ
     SFVDYE
//