Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q6EV69 (OFUT1_PANTR)

Last modified November 3, 2009. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    GDP-fucose protein O-fucosyltransferase 1
    EC=2.4.1.221
Alternative name(s):
    Peptide-O-fucosyltransferase 1
      Short name=O-FucT-1
Gene names
Name: POFUT1
Synonyms: FUT12
OrganismPan troglodytes (Chimpanzee)
Taxonomic identifier9598 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in EGF domains. Plays a crucial role in Notch signaling By similarity.

Catalytic activity

Transfers an alpha-L-fucosyl residue from GDP-beta-L-fucose to the serine hydroxy group of a protein acceptor.

Cofactor

Manganese By similarity.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Endoplasmic reticulum By similarity.

Sequence similarities

Belongs to the glycosyltransferase 68 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 388362GDP-fucose protein O-fucosyltransferase 1
PRO_0000012150

Regions

Motif385 – 3884Prevents secretion from ER Potential

Amino acid modifications

Glycosylation621N-linked (GlcNAc...) Potential
Glycosylation1601N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q6EV69-1 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 3FACCCA434D02415

FASTA38843,956
        10         20         30         40         50         60 
MGAAAWARPL SVSFLLLLLP LPGMPAGSWD PAGYLLYCPC MGRFGNQADH FLGSLAFAKL 

        70         80         90        100        110        120 
LNRTLAVPPW IEYQHHKPPF TNLHVSYQKY FKLEPLQAYH RVISLEDFME KLAPTHWPPE 

       130        140        150        160        170        180 
KRVAYCFEVA AQRSPDKKTC PMKEGNPFGP FWDQFHVSFN KSELFTGISF SASYREQWSQ 

       190        200        210        220        230        240 
RFSPKEHPVL ALPGAPAQFP VLEEHRPLQK YMVWSDEMVK TGEAQIHAHL VRPYVGIHLR 

       250        260        270        280        290        300 
IGSDWKNACA MLKDGTAGSH FMASPQCVGY SRSTAAPLTM TMCLPDLKEI QRAVKLWVRS 

       310        320        330        340        350        360 
LDAQSVYVAT DSESYVPELQ QLFKGKVKVV SLKPEVAQVD LYILGQADHF IGNCVSSFTA 

       370        380 
FVKRERDLQG RPSSFFGMDR PPKLRDEF 

« Hide

References

[1]"A new superfamily of protein-O-fucosyltransferases, alpha2-fucosyltransferases, and alpha6-fucosyltransferases: phylogeny and identification of conserved peptide motifs."
Martinez-Duncker I., Mollicone R., Candelier J.-J., Breton C., Oriol R.
Glycobiology 13:1C-5C(2003) [PubMed: 12966037] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

AJ781500 mRNA. Translation: CAH03712.1.
RefSeqNP_001008982.1.

3D structure databases

ModBaseSearch...

Protein family/group databases

CAZyGT65. Glycosyltransferase Family 65.

Genome annotation databases

EnsemblENSPTRT00000024842; ENSPTRP00000022931; ENSPTRG00000013375; Pan troglodytes. [Genome view]
GeneID449504.
KEGGptr:449504.

Organism-specific databases

CTD449504.

Phylogenomic databases

HOVERGENQ6EV69.
OMAQSVYIAT.

Enzyme and pathway databases

BRENDA2.4.1.221. 264977.

Family and domain databases

InterProIPR019378. GDP-Fuc_prot_O-FucTrfase.
[Graphical view]
PfamPF10250. O-FucT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOFUT1_PANTR
AccessionPrimary (citable) accession number: Q6EV69
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: August 16, 2004
Last modified: November 3, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents