Reviewed, UniProtKB/Swiss-Prot Q6EV56 (OFUT2_PANTR)

Names and origin

Protein names

Recommended name:
    GDP-fucose protein O-fucosyltransferase 2
    EC=2.4.1.221
Alternative name(s):
    Peptide-O-fucosyltransferase 2
      Short name=O-FucT-2

Gene names

Name:	POFUT2
Synonyms:	FUT13

Organism

Pan troglodytes (Chimpanzee)

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan

Protein attributes

Sequence length	429 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in thrombospondin type 1 repeats By similarity.
Catalytic activity	Transfers an alpha-L-fucosyl residue from GDP-beta-L-fucose to the serine hydroxy group of a protein acceptor.
Pathway	Protein modification; protein glycosylation.
Subcellular location	Endoplasmic reticulum By similarity.
Sequence similarities	Belongs to the glycosyltransferase 68 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Fucose metabolism
Cellular component	Endoplasmic reticulum
Domain	Signal
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	fucose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	peptide-O-fucosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 429	408	GDP-fucose protein O-fucosyltransferase 2		PRO_0000012156
Amino acid modifications
	Glycosylation	189	1	N-linked (GlcNAc...) Potential
	Glycosylation	209	1	N-linked (GlcNAc...) Potential
	Glycosylation	259	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6EV56-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 77A3635BD4698983	FASTA	429	49,847
	10 20 30 40 50 60 MATLSFVFLL LGAVSWPPAS ASGQEFWPGQ SAADILSGAA SRRRYLLYDV NPPEGFNLRR 70 80 90 100 110 120 DVYIRIASLL KTLLKTEEWV LVLPPWGRLY HWQSPDIHQV RIPWSEFFDL PSLNKNIPVI 130 140 150 160 170 180 EYEQFIAESG GPFIDQVYVL QSYAEGWKEG TWEEKVDERP CIDQLLYSQD KHEYYRGWFW 190 200 210 220 230 240 GYEETRGLNV SCLSVQGSAS IVAPLLLRNT SARSVMLDRA ENLLHDHYGG KEYWDTRRSM 250 260 270 280 290 300 VFARHLREVG DEFRSRHLNS TDDADGIPFQ EDWTKMKVKL GSALGGPYLG VHLRRKDFIW 310 320 330 340 350 360 GHRQDVPSLE GAVRKIRSLM KTHRLDKVFV ATDAVRKEYE ELKKLLPEMV RFEPTWEELE 370 380 390 400 410 420 LYKDGGVAII DQWICAHARF FIGTSVSTFS FRIHEEREIL GLDPKTTYNR FCGDQEKACE QPTHWKITY

References

[1]

"A new superfamily of protein-O-fucosyltransferases, alpha2-fucosyltransferases, and alpha6-fucosyltransferases: phylogeny and identification of conserved peptide motifs." Martinez-Duncker I., Mollicone R., Candelier J.-J., Breton C., Oriol R. Glycobiology 13:1C-5C(2003) [PubMed: 12966037] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ781756 mRNA. Translation: CAH03731.1.
RefSeq	NP_001008983.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6EV56.
Protein family/group databases
CAZy	GT68. Glycosyltransferase Family 68.
Genome annotation databases
Ensembl	ENSPTRT00000026129; ENSPTRP00000024102; ENSPTRG00000014001; Pan troglodytes. [Genome view]
GeneID	449505.
KEGG	ptr:449505.
Organism-specific databases
CTD	449505.
Phylogenomic databases
eggNOG	prNOG09136.
HOVERGEN	Q6EV56.
InParanoid	Q6EV56.
OMA	HARFFIG.
Enzyme and pathway databases
BRENDA	2.4.1.221. 264977.
Family and domain databases
InterPro	IPR019378. GDP-Fuc_prot_O-FucTrfase. [Graphical view]
Pfam	PF10250. O-FucT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OFUT2_PANTR

Accession

Primary (citable) accession number: Q6EV56

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	August 16, 2004
Last modified:	January 19, 2010
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)