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Protein

Forkhead box protein O1

Gene

foxo1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi149 – 24395Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • cellular glucose homeostasis Source: UniProtKB
  • cellular response to cold Source: UniProtKB
  • cellular response to hyperoxia Source: UniProtKB
  • cellular response to starvation Source: UniProtKB
  • fat cell differentiation Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of apoptotic process Source: UniProtKB
  • positive regulation of autophagy Source: UniProtKB
  • positive regulation of protein catabolic process Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • protein acetylation Source: UniProtKB
  • regulation of energy homeostasis Source: UniProtKB
  • temperature homeostasis Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein O1
Short name:
FoxO1
Short name:
xFoxO1
Alternative name(s):
FoxO1A
Gene namesi
Name:foxo11 Publication
Synonyms:foxo1aBy similarity
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-482532. foxo1.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus PROSITE-ProRule annotationBy similarity

  • Note: Shuttles between cytoplasm and nucleus.By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: UniProtKB
  • mitochondrion Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 631631Forkhead box protein O1PRO_0000270986Add
BLAST

Post-translational modificationi

Phosphorylated by AKT1; insulin-induced.By similarity
IGF1 rapidly induces phosphorylation of Thr-28, Ser-245 and Ser-308. Phosphorylation of Ser-245 decreases DNA-binding activity and promotes the phosphorylation of Thr-28, and Ser-308, which leads to nuclear exclusion and loss of function. Phosphorylation of Ser-318 is independent of IGF1 and leads to reduced function (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Expressioni

Tissue specificityi

Localized to the animal hemisphere during early cleavage stages. At early tadpole stages, expressed in the branchial arches, pronephros and liver. Within the head, expressed in the forming thyroid gland and in head mesenchyme anterior to the eyes.1 Publication

Developmental stagei

Expressed both maternally and zygotically. Maternal expression decreases during early cleavage stages becoming absent during gastrulation. Zygotic expression begins during neurulation with expression levels increasing as development progresses.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ6EUW2.
SMRiQ6EUW2. Positions 150-245.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 5450Pro-richSequence analysisAdd
BLAST
Compositional biasi89 – 11022Gln-richSequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG057789.
KOiK07201.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR032067. FOXO-TAD.
IPR032068. FOXO_KIX-bd.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
PF16676. FOXO-TAD. 1 hit.
PF16675. FOXO_KIX_bdg. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6EUW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAPQPPPP LVEIDPDFEP FSRPRSCTWP LPRPEFNPSS SANSSPAPSL
60 70 80 90 100
QPEPAAGNVD FLSNLSLLEE SEDFDPAEAL GVCGDFPCQD IRQLQPPIPQ
110 120 130 140 150
QQQQHSQQQQ EALTLLAPSV PSALSPASSP SPLGAQQPRK SSSSRRNAWG
160 170 180 190 200
NLSYADLISQ AIESSPEKRL TLSQIYDWMV KSVPYFKDKG DSNSSAGWKN
210 220 230 240 250
SIRHNLSLHS KFVRVQNEGT GKSSWWILNP EGGKNGKSPR RRAASMDNNS
260 270 280 290 300
KFAKSRGRAA KKKASMQSSQ DGSSDSPGSQ FSKWPGSPSS QSNDDFEAWS
310 320 330 340 350
TFRPRTSSNA STISGRLSPI MPEQDDLGDA DVHNLVYPSS ATKLTSTLPS
360 370 380 390 400
LSEMGNSENM ENLLDNLNLL TPNSSTQSSP ASMMQQSGYL FTSPNTSLGS
410 420 430 440 450
PNSEYRKYSY AQTGISPISQ MPMQTVPENK SGYRAVGQYP VPAGLLKELL
460 470 480 490 500
TSDSPPHNDI LTPVDPAVSQ ANNRVLGQNS LIGSNSIMPA YGSQPAPNKM
510 520 530 540 550
SSHPHLHQPN HPTSINGRPI AHNPGINRLS TVKTSVQVPM PHQPIQMTSM
560 570 580 590 600
GSYSMNSCNG YGRVGIVSIH QEILPSDLDD MLIESLDCDV ESIIRNDLME
610 620 630
DGEADFNFDS ILPNQSFPHS VTTTTHSWVS G
Length:631
Mass (Da):68,468
Last modified:August 16, 2004 - v1
Checksum:i8AE83E8A7D936845
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ783963 mRNA. Translation: CAH04456.1.
RefSeqiNP_001086417.1. NM_001092948.1.
UniGeneiXl.48324.

Genome annotation databases

GeneIDi444991.
KEGGixla:444991.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ783963 mRNA. Translation: CAH04456.1.
RefSeqiNP_001086417.1. NM_001092948.1.
UniGeneiXl.48324.

3D structure databases

ProteinModelPortaliQ6EUW2.
SMRiQ6EUW2. Positions 150-245.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi444991.
KEGGixla:444991.

Organism-specific databases

CTDi2308.
XenbaseiXB-GENE-482532. foxo1.

Phylogenomic databases

HOVERGENiHBG057789.
KOiK07201.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR032067. FOXO-TAD.
IPR032068. FOXO_KIX-bd.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
PF16676. FOXO-TAD. 1 hit.
PF16675. FOXO_KIX_bdg. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFOXO1_XENLA
AccessioniPrimary (citable) accession number: Q6EUW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: August 16, 2004
Last modified: June 8, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.