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Protein

MADS-box transcription factor 6

Gene

MADS6

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable transcription factor. Regulates floral organ identity and floral meristem determinacy. May be involved in the control of flowering time.2 Publications

GO - Molecular functioni

  • DNA binding Source: AgBase
  • protein dimerization activity Source: AgBase
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: InterPro
  • transcription factor activity, sequence-specific DNA binding Source: InterPro

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • embryo sac development Source: AgBase
  • floral meristem determinacy Source: AgBase
  • floral organ development Source: AgBase
  • floral organ formation Source: AgBase
  • floral whorl morphogenesis Source: AgBase
  • floral whorl structural organization Source: AgBase
  • integument development Source: AgBase
  • MAPK cascade Source: InterPro
  • meristem determinacy Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: InterPro
  • regulation of meristem development Source: AgBase
  • seed development Source: AgBase
  • seed growth Source: AgBase
  • specification of carpel identity Source: AgBase
  • specification of floral organ identity Source: UniProtKB
  • specification of floral organ number Source: AgBase
  • stamen formation Source: AgBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Flowering, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
MADS-box transcription factor 6
Alternative name(s):
OsMADS6
Protein MOSAIC FLORAL ORGANS 1
Gene namesi
Name:MADS6
Synonyms:MFO1
Ordered Locus Names:Os02g0682200, LOC_Os02g45770
ORF Names:OJ1123_G04.6, OsJ_07942
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
Proteomesi
  • UP000059680 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Abnormal and almost sterile florets. Mosaic organs and disturbed identities of palea and lodicule. Extra carpels or spikelets.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi24R → H in mfo1-1; loss of function. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002298951 – 250MADS-box transcription factor 6Add BLAST250

Proteomic databases

PaxDbiQ6EU39.
PRIDEiQ6EU39.

Expressioni

Tissue specificityi

Expressed in the floral meristem. Highly expressed in lodicules. Expressed in palea and pistil. Weakly expressed in carpels, empty glumes and stamens. Not detected in lemmas.2 Publications

Developmental stagei

Expressed during ovule development in the inner and outer integuments. Not detected in young panicles.2 Publications

Gene expression databases

GenevisibleiQ6EU39. OS.

Interactioni

Subunit structurei

May interact with the K-box of MADS1, MADS5, MADS7, MADS8, MADS14, MADS15, MADS16, MADS17 and MADS18. May interact with MADS13. The dimer composed of MADS6 and MADS18 forms a ternary complex with histone fold protein NF-YB1.

Binary interactionsi

WithEntry#Exp.IntActNotes
MADS1Q10PZ94EBI-627980,EBI-627957
MADS14Q10CQ15EBI-627980,EBI-627890
MADS15Q6Q9I23EBI-627980,EBI-627918
MADS18Q0D4T43EBI-627980,EBI-627967
MADS5Q0DEB83EBI-627980,EBI-627927
MADS7Q0J4665EBI-627980,EBI-627872

GO - Molecular functioni

  • protein dimerization activity Source: AgBase

Protein-protein interaction databases

IntActiQ6EU39. 15 interactors.
STRINGi39947.LOC_Os02g45770.1.

Structurei

3D structure databases

ProteinModelPortaliQ6EU39.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 61MADS-boxPROSITE-ProRule annotationAdd BLAST61
Domaini86 – 176K-boxPROSITE-ProRule annotationAdd BLAST91

Sequence similaritiesi

Contains 1 K-box domain.PROSITE-ProRule annotation
Contains 1 MADS-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0014. Eukaryota.
COG5068. LUCA.
HOGENOMiHOG000155301.
InParanoidiQ6EU39.
KOiK09264.
OMAiAGGENNF.
OrthoDBiEOG09360JNU.

Family and domain databases

CDDicd00265. MADS_MEF2_like. 1 hit.
InterProiIPR033896. MADS_MEF2-like.
IPR002487. TF_Kbox.
IPR002100. TF_MADSbox.
[Graphical view]
PfamiPF01486. K-box. 1 hit.
PF00319. SRF-TF. 1 hit.
[Graphical view]
PRINTSiPR00404. MADSDOMAIN.
SMARTiSM00432. MADS. 1 hit.
[Graphical view]
SUPFAMiSSF55455. SSF55455. 1 hit.
PROSITEiPS51297. K_BOX. 1 hit.
PS00350. MADS_BOX_1. 1 hit.
PS50066. MADS_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6EU39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRGRVELKR IENKINRQVT FSKRRNGLLK KAYELSVLCD AEVALIIFSS
60 70 80 90 100
RGKLYEFGSA GITKTLERYQ HCCYNAQDSN NALSETQSWY HEMSKLKAKF
110 120 130 140 150
EALQRTQRHL LGEDLGPLSV KELQQLEKQL ECALSQARQR KTQLMMEQVE
160 170 180 190 200
ELRRKERQLG EINRQLKHKL EVEGSTSNYR AMQQASWAQG AVVENGAAYV
210 220 230 240 250
QPPPHSAAMD SEPTLQIGYP HQFVPAEANT IQRSTAPAGA ENNFMLGWVL
Length:250
Mass (Da):28,437
Last modified:August 16, 2004 - v1
Checksum:i7E574BD86A48220C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78782 mRNA. Translation: AAB64250.1.
FJ666318 mRNA. Translation: ACV89861.1.
AP004178 Genomic DNA. Translation: BAD27830.1.
AP008208 Genomic DNA. Translation: BAF09663.1.
AP014958 Genomic DNA. Translation: BAS80308.1.
CM000139 Genomic DNA. Translation: EEE57586.1.
AK069103 mRNA. Translation: BAG91254.1.
PIRiT04167.
RefSeqiXP_015623947.1. XM_015768461.1.
UniGeneiOs.7271.

Genome annotation databases

EnsemblPlantsiOS02T0682200-01; OS02T0682200-01; OS02G0682200.
GeneIDi4330328.
GrameneiOS02T0682200-01; OS02T0682200-01; OS02G0682200.
KEGGiosa:4330328.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78782 mRNA. Translation: AAB64250.1.
FJ666318 mRNA. Translation: ACV89861.1.
AP004178 Genomic DNA. Translation: BAD27830.1.
AP008208 Genomic DNA. Translation: BAF09663.1.
AP014958 Genomic DNA. Translation: BAS80308.1.
CM000139 Genomic DNA. Translation: EEE57586.1.
AK069103 mRNA. Translation: BAG91254.1.
PIRiT04167.
RefSeqiXP_015623947.1. XM_015768461.1.
UniGeneiOs.7271.

3D structure databases

ProteinModelPortaliQ6EU39.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6EU39. 15 interactors.
STRINGi39947.LOC_Os02g45770.1.

Proteomic databases

PaxDbiQ6EU39.
PRIDEiQ6EU39.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOS02T0682200-01; OS02T0682200-01; OS02G0682200.
GeneIDi4330328.
GrameneiOS02T0682200-01; OS02T0682200-01; OS02G0682200.
KEGGiosa:4330328.

Phylogenomic databases

eggNOGiKOG0014. Eukaryota.
COG5068. LUCA.
HOGENOMiHOG000155301.
InParanoidiQ6EU39.
KOiK09264.
OMAiAGGENNF.
OrthoDBiEOG09360JNU.

Gene expression databases

GenevisibleiQ6EU39. OS.

Family and domain databases

CDDicd00265. MADS_MEF2_like. 1 hit.
InterProiIPR033896. MADS_MEF2-like.
IPR002487. TF_Kbox.
IPR002100. TF_MADSbox.
[Graphical view]
PfamiPF01486. K-box. 1 hit.
PF00319. SRF-TF. 1 hit.
[Graphical view]
PRINTSiPR00404. MADSDOMAIN.
SMARTiSM00432. MADS. 1 hit.
[Graphical view]
SUPFAMiSSF55455. SSF55455. 1 hit.
PROSITEiPS51297. K_BOX. 1 hit.
PS00350. MADS_BOX_1. 1 hit.
PS50066. MADS_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMADS6_ORYSJ
AccessioniPrimary (citable) accession number: Q6EU39
Secondary accession number(s): A0A0P0VN09, O24228, Q0DYM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: August 16, 2004
Last modified: November 30, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.