Q6EU10 (MTA70_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable N6-adenosine-methyltransferase MT-A70-like
EC=2.1.1.62

Gene names

Ordered Locus Names:	Os02g0672600, LOC_Os02g45110
ORF Names:	OJ1197_E09.7, OJ1493_H11.20

Organism

Oryza sativa subsp. japonica (Rice) [Reference proteome]

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Liliopsida › commelinids › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza › Oryza sativa

Protein attributes

Sequence length	706 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which is present at internal sites of some mRNAs, may play a role in the efficiency of mRNA splicing, transport or translation By similarity.
Catalytic activity	S-adenosyl-L-methionine + m7G(5')pppAm = S-adenosyl-L-homocysteine + m7G(5')pppm6Am.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the MT-A70-like family.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	RNA-binding S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	chloroplast Inferred from electronic annotation. Source: EnsemblPlants/Gramene nuclear speck Inferred from electronic annotation. Source: EnsemblPlants/Gramene
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 706	706	Probable N6-adenosine-methyltransferase MT-A70-like		PRO_0000260072
Regions
	Compositional bias	252 – 257	6	Poly-Gln
Experimental info
	Sequence conflict	504	1	M → I in AK101174. Ref.3
	Sequence conflict	513	1	D → N in AK101174. Ref.3
	Sequence conflict	537	1	R → L in AK070286. Ref.3
	Sequence conflict	614	1	K → R in AK101174. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q6EU10 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 91BDDF2AAEABA405	FASTA	706	77,803
	10 20 30 40 50 60 MEAQADAGGD DLAAMREQCR SLEEAIGFRR ETQMGLVASL QRLVPDLVPS LDRSLRIIAA 70 80 90 100 110 120 FNDRPFVPTP NPDGGHGKSP AALKPHHRRA LPDPARSTRR KTSPGSSPAS VAAAPGGLDA 130 140 150 160 170 180 VRTMVAVCLL ELVPFAEIDA AALARRLQAE SSSASEAERT ALADLAAELG GSAASAVVLA 190 200 210 220 230 240 LRRIAEDTGG VQIEEAMIGG KSMTMVWAID RNKLLKELPE SATLPLLQPP PAPQMPPSET 250 260 270 280 290 300 DAGSAMIPRT PQQQQPQPDM WPHSMPPIFP RPRGMTMQGM QRVPGVPPGL MPLQRPFMGP 310 320 330 340 350 360 AGVITMGGGV GPSPNQQKQK SEEDELKDLE LLLNKKTYRE KQNTKTGEEL LDLIHRPTAK 370 380 390 400 410 420 ETAVAAKFKT KGGSQLKEYC TNLTKEDCRR QSGSFVACDK VHFRRIIAPH TDTNLGDCSF 430 440 450 460 470 480 LDTCRHTKTC KYVHYELDQT PDIPPMMAGA LAPPRQIRLQ RAEYCSEVEL GEAQWINCDI 490 500 510 520 530 540 RNFRMDILGQ FGVIMADPPW DIHMELPYGT MADDEMRTLN VPALQTDGLI FLWVTGRAME 550 560 570 580 590 600 LGRECLELWG YKRVEEIIWV KTNQLQRIIR TGRTGHWLNH SKEHCLVGIK GNPLVNRNID 610 620 630 640 650 660 TDVIVAEVRE TSRKPDEMYP MLERISPRTR KLELFARMHN AHAGWLSLGN QLNGVRLVDE 670 680 690 700 GLRARYKAAY PDSEVQPPSP PRASAPIDGD QGTSQKPTVS DGERPA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The map-based sequence of the rice genome." International rice genome sequencing project (IRGSP) Nature 436:793-800(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[2]	"The rice annotation project database (RAP-DB): 2008 update." The rice annotation project (RAP) Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: cv. Nipponbare.
[3]	"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice." The rice full-length cDNA consortium Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Nipponbare.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP004160 Genomic DNA. Translation: BAD27818.1. AP004188 Genomic DNA. Translation: BAD27860.1. AP008208 Genomic DNA. Translation: BAF09621.1. AK070286 mRNA. No translation available. AK101174 mRNA. No translation available.
RefSeq	NP_001047707.1. NM_001054242.1.
UniGene	Os.20898.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	39947.LOC_Os02g45110.1.
Proteomic databases
PRIDE	Q6EU10.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	LOC_Os02g45110.1; LOC_Os02g45110.1; LOC_Os02g45110.
GeneID	4330284.
KEGG	osa:4330284.
Organism-specific databases
Gramene	Q6EU10.
Phylogenomic databases
eggNOG	COG4725.
HOGENOM	HOG000077476.
KO	K05925.
OMA	ELFARMH.
ProtClustDB	CLSN2686057.
Family and domain databases
InterPro	IPR007757. MT-A70-like. [Graphical view]
Pfam	PF05063. MT-A70. 1 hit. [Graphical view]
PROSITE	PS51143. MT_A70. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTA70_ORYSJ

Accession

Primary (citable) accession number: Q6EU10

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	August 16, 2004
Last modified:	April 3, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program