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Protein

Probable N6-adenosine-methyltransferase MT-A70-like

Gene

Os02g0672600

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which is present at internal sites of some mRNAs, may play a role in the efficiency of mRNA splicing, transport or translation (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + m7G(5')pppAm = S-adenosyl-L-homocysteine + m7G(5')pppm6Am.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiREACT_281481. Processing of Capped Intron-Containing Pre-mRNA.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N6-adenosine-methyltransferase MT-A70-like (EC:2.1.1.62)
Gene namesi
Ordered Locus Names:Os02g0672600, LOC_Os02g45110
ORF Names:OJ1197_E09.7, OJ1493_H11.20
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
ProteomesiUP000000763 Componenti: Chromosome 2

Organism-specific databases

GrameneiQ6EU10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 706706Probable N6-adenosine-methyltransferase MT-A70-likePRO_0000260072Add
BLAST

Proteomic databases

PRIDEiQ6EU10.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os02g45110.1.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi252 – 2576Poly-Gln

Sequence similaritiesi

Belongs to the MT-A70-like family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG4725.
HOGENOMiHOG000077476.
InParanoidiQ6EU10.
KOiK05925.
OMAiRAMVAVC.

Family and domain databases

InterProiIPR007757. MT-A70-like.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF05063. MT-A70. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51143. MT_A70. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6EU10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAQADAGGD DLAAMREQCR SLEEAIGFRR ETQMGLVASL QRLVPDLVPS
60 70 80 90 100
LDRSLRIIAA FNDRPFVPTP NPDGGHGKSP AALKPHHRRA LPDPARSTRR
110 120 130 140 150
KTSPGSSPAS VAAAPGGLDA VRTMVAVCLL ELVPFAEIDA AALARRLQAE
160 170 180 190 200
SSSASEAERT ALADLAAELG GSAASAVVLA LRRIAEDTGG VQIEEAMIGG
210 220 230 240 250
KSMTMVWAID RNKLLKELPE SATLPLLQPP PAPQMPPSET DAGSAMIPRT
260 270 280 290 300
PQQQQPQPDM WPHSMPPIFP RPRGMTMQGM QRVPGVPPGL MPLQRPFMGP
310 320 330 340 350
AGVITMGGGV GPSPNQQKQK SEEDELKDLE LLLNKKTYRE KQNTKTGEEL
360 370 380 390 400
LDLIHRPTAK ETAVAAKFKT KGGSQLKEYC TNLTKEDCRR QSGSFVACDK
410 420 430 440 450
VHFRRIIAPH TDTNLGDCSF LDTCRHTKTC KYVHYELDQT PDIPPMMAGA
460 470 480 490 500
LAPPRQIRLQ RAEYCSEVEL GEAQWINCDI RNFRMDILGQ FGVIMADPPW
510 520 530 540 550
DIHMELPYGT MADDEMRTLN VPALQTDGLI FLWVTGRAME LGRECLELWG
560 570 580 590 600
YKRVEEIIWV KTNQLQRIIR TGRTGHWLNH SKEHCLVGIK GNPLVNRNID
610 620 630 640 650
TDVIVAEVRE TSRKPDEMYP MLERISPRTR KLELFARMHN AHAGWLSLGN
660 670 680 690 700
QLNGVRLVDE GLRARYKAAY PDSEVQPPSP PRASAPIDGD QGTSQKPTVS

DGERPA
Length:706
Mass (Da):77,803
Last modified:August 16, 2004 - v1
Checksum:i91BDDF2AAEABA405
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti504 – 5041M → I in AK101174 (PubMed:12869764).Curated
Sequence conflicti513 – 5131D → N in AK101174 (PubMed:12869764).Curated
Sequence conflicti537 – 5371R → L in AK070286 (PubMed:12869764).Curated
Sequence conflicti614 – 6141K → R in AK101174 (PubMed:12869764).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP004160 Genomic DNA. Translation: BAD27818.1.
AP004188 Genomic DNA. Translation: BAD27860.1.
AP008208 Genomic DNA. Translation: BAF09621.1.
AK070286 mRNA. No translation available.
AK101174 mRNA. No translation available.
RefSeqiNP_001047707.1. NM_001054242.1.
UniGeneiOs.20898.

Genome annotation databases

EnsemblPlantsiOS02T0672600-01; OS02T0672600-01; OS02G0672600.
GeneIDi4330284.
KEGGiosa:4330284.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP004160 Genomic DNA. Translation: BAD27818.1.
AP004188 Genomic DNA. Translation: BAD27860.1.
AP008208 Genomic DNA. Translation: BAF09621.1.
AK070286 mRNA. No translation available.
AK101174 mRNA. No translation available.
RefSeqiNP_001047707.1. NM_001054242.1.
UniGeneiOs.20898.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os02g45110.1.

Proteomic databases

PRIDEiQ6EU10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOS02T0672600-01; OS02T0672600-01; OS02G0672600.
GeneIDi4330284.
KEGGiosa:4330284.

Organism-specific databases

GrameneiQ6EU10.

Phylogenomic databases

eggNOGiCOG4725.
HOGENOMiHOG000077476.
InParanoidiQ6EU10.
KOiK05925.
OMAiRAMVAVC.

Enzyme and pathway databases

ReactomeiREACT_281481. Processing of Capped Intron-Containing Pre-mRNA.

Family and domain databases

InterProiIPR007757. MT-A70-like.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF05063. MT-A70. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51143. MT_A70. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  3. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiMTA70_ORYSJ
AccessioniPrimary (citable) accession number: Q6EU10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: August 16, 2004
Last modified: July 22, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.