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Q6EU10

- MTA70_ORYSJ

UniProt

Q6EU10 - MTA70_ORYSJ

Protein

Probable N6-adenosine-methyltransferase MT-A70-like

Gene

Os02g0672600

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Probable N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which is present at internal sites of some mRNAs, may play a role in the efficiency of mRNA splicing, transport or translation By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + m7G(5')pppAm = S-adenosyl-L-homocysteine + m7G(5')pppm6Am.

    GO - Molecular functioni

    1. mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity Source: UniProtKB-EC
    2. RNA binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Ligandi

    RNA-binding, S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable N6-adenosine-methyltransferase MT-A70-like (EC:2.1.1.62)
    Gene namesi
    Ordered Locus Names:Os02g0672600, LOC_Os02g45110
    ORF Names:OJ1197_E09.7, OJ1493_H11.20
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 2

    Organism-specific databases

    GrameneiQ6EU10.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. chloroplast Source: EnsemblPlants/Gramene
    2. nuclear speck Source: EnsemblPlants/Gramene

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 706706Probable N6-adenosine-methyltransferase MT-A70-likePRO_0000260072Add
    BLAST

    Proteomic databases

    PRIDEiQ6EU10.

    Interactioni

    Protein-protein interaction databases

    STRINGi39947.LOC_Os02g45110.1.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi252 – 2576Poly-Gln

    Sequence similaritiesi

    Belongs to the MT-A70-like family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG4725.
    HOGENOMiHOG000077476.
    KOiK05925.
    OMAiEDCRRQT.

    Family and domain databases

    InterProiIPR007757. MT-A70-like.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF05063. MT-A70. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51143. MT_A70. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6EU10-1 [UniParc]FASTAAdd to Basket

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    MEAQADAGGD DLAAMREQCR SLEEAIGFRR ETQMGLVASL QRLVPDLVPS    50
    LDRSLRIIAA FNDRPFVPTP NPDGGHGKSP AALKPHHRRA LPDPARSTRR 100
    KTSPGSSPAS VAAAPGGLDA VRTMVAVCLL ELVPFAEIDA AALARRLQAE 150
    SSSASEAERT ALADLAAELG GSAASAVVLA LRRIAEDTGG VQIEEAMIGG 200
    KSMTMVWAID RNKLLKELPE SATLPLLQPP PAPQMPPSET DAGSAMIPRT 250
    PQQQQPQPDM WPHSMPPIFP RPRGMTMQGM QRVPGVPPGL MPLQRPFMGP 300
    AGVITMGGGV GPSPNQQKQK SEEDELKDLE LLLNKKTYRE KQNTKTGEEL 350
    LDLIHRPTAK ETAVAAKFKT KGGSQLKEYC TNLTKEDCRR QSGSFVACDK 400
    VHFRRIIAPH TDTNLGDCSF LDTCRHTKTC KYVHYELDQT PDIPPMMAGA 450
    LAPPRQIRLQ RAEYCSEVEL GEAQWINCDI RNFRMDILGQ FGVIMADPPW 500
    DIHMELPYGT MADDEMRTLN VPALQTDGLI FLWVTGRAME LGRECLELWG 550
    YKRVEEIIWV KTNQLQRIIR TGRTGHWLNH SKEHCLVGIK GNPLVNRNID 600
    TDVIVAEVRE TSRKPDEMYP MLERISPRTR KLELFARMHN AHAGWLSLGN 650
    QLNGVRLVDE GLRARYKAAY PDSEVQPPSP PRASAPIDGD QGTSQKPTVS 700
    DGERPA 706
    Length:706
    Mass (Da):77,803
    Last modified:August 16, 2004 - v1
    Checksum:i91BDDF2AAEABA405
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti504 – 5041M → I in AK101174. (PubMed:12869764)Curated
    Sequence conflicti513 – 5131D → N in AK101174. (PubMed:12869764)Curated
    Sequence conflicti537 – 5371R → L in AK070286. (PubMed:12869764)Curated
    Sequence conflicti614 – 6141K → R in AK101174. (PubMed:12869764)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP004160 Genomic DNA. Translation: BAD27818.1.
    AP004188 Genomic DNA. Translation: BAD27860.1.
    AP008208 Genomic DNA. Translation: BAF09621.1.
    AK070286 mRNA. No translation available.
    AK101174 mRNA. No translation available.
    RefSeqiNP_001047707.1. NM_001054242.1.
    UniGeneiOs.20898.

    Genome annotation databases

    EnsemblPlantsiOS02T0672600-01; OS02T0672600-01; OS02G0672600.
    GeneIDi4330284.
    KEGGiosa:4330284.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP004160 Genomic DNA. Translation: BAD27818.1 .
    AP004188 Genomic DNA. Translation: BAD27860.1 .
    AP008208 Genomic DNA. Translation: BAF09621.1 .
    AK070286 mRNA. No translation available.
    AK101174 mRNA. No translation available.
    RefSeqi NP_001047707.1. NM_001054242.1.
    UniGenei Os.20898.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 39947.LOC_Os02g45110.1.

    Proteomic databases

    PRIDEi Q6EU10.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS02T0672600-01 ; OS02T0672600-01 ; OS02G0672600 .
    GeneIDi 4330284.
    KEGGi osa:4330284.

    Organism-specific databases

    Gramenei Q6EU10.

    Phylogenomic databases

    eggNOGi COG4725.
    HOGENOMi HOG000077476.
    KOi K05925.
    OMAi EDCRRQT.

    Family and domain databases

    InterProi IPR007757. MT-A70-like.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF05063. MT-A70. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51143. MT_A70. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. "The rice annotation project database (RAP-DB): 2008 update."
      The rice annotation project (RAP)
      Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: cv. Nipponbare.
    3. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
      The rice full-length cDNA consortium
      Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiMTA70_ORYSJ
    AccessioniPrimary (citable) accession number: Q6EU10
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3