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Protein

Probable protein phosphatase 2C member 13, mitochondrial

Gene

PP2C13

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable protein phosphatase that may play a role as a mitochondrial signal transduction mediator in pollen germination. May function in retrograde signaling from the mitochondria to the nucleus. May be a downstream factor of cytoplasmic male sterility (CMS). CMS is caused by genetic incompatibility between nuclei and mitochondria within male reproductive organs.1 Publication

Miscellaneous

Plants silencing PP2C13 exhibit a major loss of seed-set fertility, without visible defect in pollen development. Plants silencing PP2C13 show up-regulation of AOX1A gene which is regulated by mitochondrial retrograde signaling.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi147Manganese 1By similarity1
Metal bindingi147Manganese 2By similarity1
Metal bindingi148Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi309Manganese 2By similarity1
Metal bindingi348Manganese 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C member 13, mitochondrialCurated (EC:3.1.3.16Curated)
Short name:
OsPP2C131 Publication
Alternative name(s):
Protein DOWNREGULATED IN CW-CMS 111 Publication
Gene namesi
Name:PP2C131 Publication
Synonyms:DCW111 Publication
Ordered Locus Names:Os02g0255100Imported, LOC_Os02g15594Curated
ORF Names:OSJNBa0052K15.14Imported
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 59MitochondrionSequence analysisAdd BLAST59
ChainiPRO_000036325960 – 363Probable protein phosphatase 2C member 13, mitochondrialAdd BLAST304

Proteomic databases

PaxDbiQ6EN45.
PRIDEiQ6EN45.

Expressioni

Tissue specificityi

Highly expressed in mature pollen grains.1 Publication

Developmental stagei

Expressed in anthers from the bi-cellluar to the tri-cellular pollen stage.1 Publication

Gene expression databases

ExpressionAtlasiQ6EN45. baseline and differential.
GenevisibleiQ6EN45. OS.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os02g15594.1.

Structurei

3D structure databases

ProteinModelPortaliQ6EN45.
SMRiQ6EN45.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini111 – 357PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST247

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi18 – 22Poly-Thr5

Sequence similaritiesi

Belongs to the PP2C family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0698. Eukaryota.
COG0631. LUCA.
HOGENOMiHOG000233896.
InParanoidiQ6EN45.
KOiK17506.
OMAiTYQKTDS.
OrthoDBiEOG09360FJK.

Family and domain databases

CDDicd00143. PP2Cc. 1 hit.
Gene3Di3.60.40.10. 2 hits.
InterProiView protein in InterPro
IPR015655. PP2C.
IPR000222. PP2C_BS.
IPR036457. PPM-type_dom_sf.
IPR001932. PPM-type_phosphatase_dom.
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiView protein in Pfam
PF00481. PP2C. 1 hit.
SMARTiView protein in SMART
SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiView protein in PROSITE
PS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6EN45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCFASLRRA LPLLLRATTT TTPRFLLPRA LSGGVGGGAA VDARALLRGH
60 70 80 90 100
SGWRGLRVAA RMMLDSSDSA AAAGQMQPQQ RAAGAVACSA QDGGAAGYAS
110 120 130 140 150
GGWAREDGKL KCGYSSFRGK RATMEDFYDV KLTEIDGQAV SLFGVFDGHG
160 170 180 190 200
GPRAAEYLKE NLFENLLKHP EFLTDTKLAI SETYQKTDTD FLESESNAFR
210 220 230 240 250
DDGSTASTAV LVGGHLYVAN VGDSRAVVSK AGKAMALSED HKPNRSDERK
260 270 280 290 300
RIENAGGVVI WAGTWRVGGV LAMSRAFGNR LLKPFVVAEP EIQEELVNED
310 320 330 340 350
LECLVLASDG LWDVVENEEA VSLAKTEDLP ESVARKLTEI AYSRGSADNI
360
TCIVVQFHHD KTE
Length:363
Mass (Da):38,958
Last modified:August 16, 2004 - v1
Checksum:iCD1318CCA7E043C7
GO

Sequence cautioni

Q6EN45: The sequence AK069289 differs from that shown. Reason: Erroneous termination at position 261. Translated as Trp.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti261Missing in AK069289 (PubMed:12869764).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006844 Genomic DNA. Translation: BAD29690.1.
AP008208 Genomic DNA. Translation: BAF08375.1.
AP014958 Genomic DNA. Translation: BAS77942.1.
AK069289 mRNA. No translation available.
RefSeqiXP_015625481.1. XM_015769995.1.
UniGeneiOs.27158.

Genome annotation databases

EnsemblPlantsiOS02T0255100-01; OS02T0255100-01; OS02G0255100.
GeneIDi4328913.
GrameneiOS02T0255100-01; OS02T0255100-01; OS02G0255100.
KEGGiosa:4328913.

Similar proteinsi

Entry informationi

Entry nameiP2C13_ORYSJ
AccessioniPrimary (citable) accession number: Q6EN45
Secondary accession number(s): A0A0P0VH70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: August 16, 2004
Last modified: October 25, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families