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Q6EMS9

- COX1_BOSIN

UniProt

Q6EMS9 - COX1_BOSIN

Protein

Cytochrome c oxidase subunit 1

Gene

MT-CO1

Organism
Bos indicus (Zebu)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi61 – 611Iron (heme A axial ligand)Curated
    Metal bindingi244 – 2441Copper BCurated
    Metal bindingi290 – 2901Copper BCurated
    Metal bindingi291 – 2911Copper BCurated
    Metal bindingi376 – 3761Iron (heme A3 axial ligand)Curated
    Metal bindingi378 – 3781Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. hydrogen ion transmembrane transport Source: GOC
    3. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:MT-CO1
    Synonyms:COI, COXI, MTCO1
    Encoded oniMitochondrion
    OrganismiBos indicus (Zebu)
    Taxonomic identifieri9915 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain complex IV Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 514514Cytochrome c oxidase subunit 1PRO_0000253785Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki240 ↔ 2441'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6EMS9.
    SMRiQ6EMS9. Positions 1-514.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1111Mitochondrial matrixBy similarityAdd
    BLAST
    Topological domaini41 – 5010Mitochondrial intermembraneBy similarity
    Topological domaini87 – 948Mitochondrial matrixBy similarity
    Topological domaini118 – 14023Mitochondrial intermembraneBy similarityAdd
    BLAST
    Topological domaini171 – 18212Mitochondrial matrixBy similarityAdd
    BLAST
    Topological domaini213 – 22715Mitochondrial intermembraneBy similarityAdd
    BLAST
    Topological domaini262 – 2698Mitochondrial matrixBy similarity
    Topological domaini287 – 29812Mitochondrial intermembraneBy similarityAdd
    BLAST
    Topological domaini328 – 3358Mitochondrial matrixBy similarity
    Topological domaini358 – 37013Mitochondrial intermembraneBy similarityAdd
    BLAST
    Topological domaini401 – 4066Mitochondrial matrixBy similarity
    Topological domaini434 – 44613Mitochondrial intermembraneBy similarityAdd
    BLAST
    Topological domaini479 – 51436Mitochondrial matrixBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 4029Helical; Name=IBy similarityAdd
    BLAST
    Transmembranei51 – 8636Helical; Name=IIBy similarityAdd
    BLAST
    Transmembranei95 – 11723Helical; Name=IIIBy similarityAdd
    BLAST
    Transmembranei141 – 17030Helical; Name=IVBy similarityAdd
    BLAST
    Transmembranei183 – 21230Helical; Name=VBy similarityAdd
    BLAST
    Transmembranei228 – 26134Helical; Name=VIBy similarityAdd
    BLAST
    Transmembranei270 – 28617Helical; Name=VIIBy similarityAdd
    BLAST
    Transmembranei299 – 32729Helical; Name=VIIIBy similarityAdd
    BLAST
    Transmembranei336 – 35722Helical; Name=IXBy similarityAdd
    BLAST
    Transmembranei371 – 40030Helical; Name=XBy similarityAdd
    BLAST
    Transmembranei407 – 43327Helical; Name=XIBy similarityAdd
    BLAST
    Transmembranei447 – 47832Helical; Name=XIIBy similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG003841.

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6EMS9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFINRWLFST NHKDIGTLYL LFGAWAGMVG TALSLLIRAE LGQPGTLLGD    50
    DQIYNVVVTA HAFVMIFFMV MPIMIGGFGN WLVPLMIGAP DMAFPRMNNM 100
    SFWLLPPSFL LLLASSMVEA GAGTGWTVYP PLAGNLAHAG ASVDLTIFSL 150
    HLAGVSSILG AINFITTIIN MKPPAMSQYQ TPLFVWSVMI TAVLLLLSLP 200
    VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH PEVYILILPG 250
    FGMISHIVTY YSGKKEPFGY MGMVWAMMSI GFLGFIVWAH HMFTVGMDVD 300
    TRAYFTSATM IIAIPTGVKV FSWLATLHGG NIKWSPAMMW ALGFIFLFTV 350
    GGLTGIVLAN SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM GGFVHWFPLF 400
    SGYTLNDTWA KIHFAIMFVG VNMTFFPQHF LGLSGMPRRY SDYPDAYTMW 450
    NTISSMGSFI SLTAVMLMVF IIWEAFASKR EVLTVDLTTT NLEWLNGCPP 500
    PYHTFEEPTY VNLK 514
    Length:514
    Mass (Da):57,032
    Last modified:August 16, 2004 - v1
    Checksum:i0D7C807D7FA3996C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF492350 Genomic DNA. Translation: AAQ06582.1.
    AY126697 Genomic DNA. Translation: AAM95732.1.
    RefSeqiYP_052699.1. NC_005971.1.

    Genome annotation databases

    GeneIDi2885981.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF492350 Genomic DNA. Translation: AAQ06582.1 .
    AY126697 Genomic DNA. Translation: AAM95732.1 .
    RefSeqi YP_052699.1. NC_005971.1.

    3D structure databases

    ProteinModelPortali Q6EMS9.
    SMRi Q6EMS9. Positions 1-514.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2885981.

    Organism-specific databases

    CTDi 4512.

    Phylogenomic databases

    HOVERGENi HBG003841.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of the Bos indicus mitochondrial genome."
      Hiendleder S., Lewalski H., Wolf E.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Liver.
    2. "The complete mitochondrial genome nucleotide sequence of Bos indicus."
      Miretti M.M., Pereira H.A. Jr., Greggio C., Suzuki J. Jr., Ferro J.A., Ferro M.I., Meirelles F., Garcia J.M., Smith L.C.
      Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCOX1_BOSIN
    AccessioniPrimary (citable) accession number: Q6EMS9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3