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Q6EMS9

- COX1_BOSIN

UniProt

Q6EMS9 - COX1_BOSIN

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Protein
Cytochrome c oxidase subunit 1
Gene
MT-CO1, COI, COXI, MTCO1
Organism
Bos indicus (Zebu)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi61 – 611Iron (heme A axial ligand) Inferred
Metal bindingi244 – 2441Copper B Inferred
Metal bindingi290 – 2901Copper B Inferred
Metal bindingi291 – 2911Copper B Inferred
Metal bindingi376 – 3761Iron (heme A3 axial ligand) Inferred
Metal bindingi378 – 3781Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. hydrogen ion transmembrane transport Source: GOC
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:MT-CO1
Synonyms:COI, COXI, MTCO1
Encoded oniMitochondrion
OrganismiBos indicus (Zebu)
Taxonomic identifieri9915 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111Mitochondrial matrix By similarity
Add
BLAST
Transmembranei12 – 4029Helical; Name=I; By similarity
Add
BLAST
Topological domaini41 – 5010Mitochondrial intermembrane By similarity
Transmembranei51 – 8636Helical; Name=II; By similarity
Add
BLAST
Topological domaini87 – 948Mitochondrial matrix By similarity
Transmembranei95 – 11723Helical; Name=III; By similarity
Add
BLAST
Topological domaini118 – 14023Mitochondrial intermembrane By similarity
Add
BLAST
Transmembranei141 – 17030Helical; Name=IV; By similarity
Add
BLAST
Topological domaini171 – 18212Mitochondrial matrix By similarity
Add
BLAST
Transmembranei183 – 21230Helical; Name=V; By similarity
Add
BLAST
Topological domaini213 – 22715Mitochondrial intermembrane By similarity
Add
BLAST
Transmembranei228 – 26134Helical; Name=VI; By similarity
Add
BLAST
Topological domaini262 – 2698Mitochondrial matrix By similarity
Transmembranei270 – 28617Helical; Name=VII; By similarity
Add
BLAST
Topological domaini287 – 29812Mitochondrial intermembrane By similarity
Add
BLAST
Transmembranei299 – 32729Helical; Name=VIII; By similarity
Add
BLAST
Topological domaini328 – 3358Mitochondrial matrix By similarity
Transmembranei336 – 35722Helical; Name=IX; By similarity
Add
BLAST
Topological domaini358 – 37013Mitochondrial intermembrane By similarity
Add
BLAST
Transmembranei371 – 40030Helical; Name=X; By similarity
Add
BLAST
Topological domaini401 – 4066Mitochondrial matrix By similarity
Transmembranei407 – 43327Helical; Name=XI; By similarity
Add
BLAST
Topological domaini434 – 44613Mitochondrial intermembrane By similarity
Add
BLAST
Transmembranei447 – 47832Helical; Name=XII; By similarity
Add
BLAST
Topological domaini479 – 51436Mitochondrial matrix By similarity
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Cytochrome c oxidase subunit 1
PRO_0000253785Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki240 ↔ 2441'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6EMS9.
SMRiQ6EMS9. Positions 1-514.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG003841.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6EMS9-1 [UniParc]FASTAAdd to Basket

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MFINRWLFST NHKDIGTLYL LFGAWAGMVG TALSLLIRAE LGQPGTLLGD    50
DQIYNVVVTA HAFVMIFFMV MPIMIGGFGN WLVPLMIGAP DMAFPRMNNM 100
SFWLLPPSFL LLLASSMVEA GAGTGWTVYP PLAGNLAHAG ASVDLTIFSL 150
HLAGVSSILG AINFITTIIN MKPPAMSQYQ TPLFVWSVMI TAVLLLLSLP 200
VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH PEVYILILPG 250
FGMISHIVTY YSGKKEPFGY MGMVWAMMSI GFLGFIVWAH HMFTVGMDVD 300
TRAYFTSATM IIAIPTGVKV FSWLATLHGG NIKWSPAMMW ALGFIFLFTV 350
GGLTGIVLAN SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM GGFVHWFPLF 400
SGYTLNDTWA KIHFAIMFVG VNMTFFPQHF LGLSGMPRRY SDYPDAYTMW 450
NTISSMGSFI SLTAVMLMVF IIWEAFASKR EVLTVDLTTT NLEWLNGCPP 500
PYHTFEEPTY VNLK 514
Length:514
Mass (Da):57,032
Last modified:August 16, 2004 - v1
Checksum:i0D7C807D7FA3996C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF492350 Genomic DNA. Translation: AAQ06582.1.
AY126697 Genomic DNA. Translation: AAM95732.1.
RefSeqiYP_052699.1. NC_005971.1.

Genome annotation databases

GeneIDi2885981.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF492350 Genomic DNA. Translation: AAQ06582.1 .
AY126697 Genomic DNA. Translation: AAM95732.1 .
RefSeqi YP_052699.1. NC_005971.1.

3D structure databases

ProteinModelPortali Q6EMS9.
SMRi Q6EMS9. Positions 1-514.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2885981.

Organism-specific databases

CTDi 4512.

Phylogenomic databases

HOVERGENi HBG003841.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of the Bos indicus mitochondrial genome."
    Hiendleder S., Lewalski H., Wolf E.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.
  2. "The complete mitochondrial genome nucleotide sequence of Bos indicus."
    Miretti M.M., Pereira H.A. Jr., Greggio C., Suzuki J. Jr., Ferro J.A., Ferro M.I., Meirelles F., Garcia J.M., Smith L.C.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX1_BOSIN
AccessioniPrimary (citable) accession number: Q6EMS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: August 16, 2004
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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