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Protein

Vasorin

Gene

VASN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as an inhibitor of TGF-beta signaling.1 Publication

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • transforming growth factor beta binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Vasorin
Alternative name(s):
Protein slit-like 2
Gene namesi
Name:VASN
Synonyms:SLITL2
ORF Names:UNQ314/PRO357/PRO1282
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:18517. VASN.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 575ExtracellularSequence analysisAdd BLAST552
Transmembranei576 – 596HelicalSequence analysisAdd BLAST21
Topological domaini597 – 673CytoplasmicSequence analysisAdd BLAST77

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • cell surface Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • lysosomal membrane Source: UniProtKB
  • mitochondrion Source: Ensembl
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168140.
ENSG00000274334.
PharmGKBiPA134974883.

Polymorphism and mutation databases

BioMutaiVASN.
DMDMi74748436.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000023263024 – 673VasorinAdd BLAST650

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi101N-linked (GlcNAc...)1 Publication1
Glycosylationi117N-linked (GlcNAc...) (complex)3 Publications1
Glycosylationi273N-linked (GlcNAc...)2 Publications1
Disulfide bondi409 ↔ 420PROSITE-ProRule annotation
Disulfide bondi414 ↔ 430PROSITE-ProRule annotation
Disulfide bondi432 ↔ 441PROSITE-ProRule annotation
Glycosylationi500N-linked (GlcNAc...)Sequence analysis1
Glycosylationi528N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated. N-glycan heterogeneity at Asn-117: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major), Hex6HexNAc5 (minor) and dHex1Hex6HexNAc5 (minor).5 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ6EMK4.
MaxQBiQ6EMK4.
PaxDbiQ6EMK4.
PeptideAtlasiQ6EMK4.
PRIDEiQ6EMK4.

PTM databases

iPTMnetiQ6EMK4.
PhosphoSitePlusiQ6EMK4.
SwissPalmiQ6EMK4.
UniCarbKBiQ6EMK4.

Expressioni

Tissue specificityi

Expressed at highest levels in aorta, at intermediate levels in kidney and placenta and at lowest levels in brain, heart, liver, lung and skeletal muscle. Within the aorta, the strongest expression is found in the tunica media of the proximal ascending aorta, the descending thoracic aorta, the abdominal aorta and the coronary arteries. Within the kidney, expression is found in the interstitial cells.1 Publication

Gene expression databases

BgeeiENSG00000168140.
CleanExiHS_VASN.
GenevisibleiQ6EMK4. HS.

Organism-specific databases

HPAiHPA011246.

Interactioni

Subunit structurei

Interacts with TGFB1, TGFB2 and TGFB3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RNF31Q96EP0-33EBI-10249550,EBI-10225152

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • transforming growth factor beta binding Source: UniProtKB

Protein-protein interaction databases

BioGridi125406. 70 interactors.
DIPiDIP-46245N.
IntActiQ6EMK4. 23 interactors.
STRINGi9606.ENSP00000306864.

Structurei

3D structure databases

ProteinModelPortaliQ6EMK4.
SMRiQ6EMK4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 51LRRNTAdd BLAST28
Repeati52 – 74LRR 1Add BLAST23
Repeati77 – 98LRR 2Add BLAST22
Repeati101 – 122LRR 3Add BLAST22
Repeati125 – 146LRR 4Add BLAST22
Repeati149 – 170LRR 5Add BLAST22
Repeati171 – 191LRR 6Add BLAST21
Repeati193 – 214LRR 7Add BLAST22
Repeati217 – 238LRR 8Add BLAST22
Repeati240 – 262LRR 9Add BLAST23
Repeati265 – 287LRR 10Add BLAST23
Domaini298 – 351LRRCTAdd BLAST54
Domaini405 – 442EGF-likePROSITE-ProRule annotationAdd BLAST38
Domaini460 – 558Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST99

Sequence similaritiesi

Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation
Contains 10 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

EGF-like domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00730000111167.
HOGENOMiHOG000261606.
HOVERGENiHBG084318.
InParanoidiQ6EMK4.
OMAiDFGCPAT.
OrthoDBiEOG091G04XS.
PhylomeDBiQ6EMK4.
TreeFamiTF351825.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 1 hit.
SM00369. LRR_TYP. 8 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50853. FN3. 1 hit.
PS51450. LRR. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6EMK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCSRVPLLLP LLLLLALGPG VQGCPSGCQC SQPQTVFCTA RQGTTVPRDV
60 70 80 90 100
PPDTVGLYVF ENGITMLDAG SFAGLPGLQL LDLSQNQIAS LPSGVFQPLA
110 120 130 140 150
NLSNLDLTAN RLHEITNETF RGLRRLERLY LGKNRIRHIQ PGAFDTLDRL
160 170 180 190 200
LELKLQDNEL RALPPLRLPR LLLLDLSHNS LLALEPGILD TANVEALRLA
210 220 230 240 250
GLGLQQLDEG LFSRLRNLHD LDVSDNQLER VPPVIRGLRG LTRLRLAGNT
260 270 280 290 300
RIAQLRPEDL AGLAALQELD VSNLSLQALP GDLSGLFPRL RLLAAARNPF
310 320 330 340 350
NCVCPLSWFG PWVRESHVTL ASPEETRCHF PPKNAGRLLL ELDYADFGCP
360 370 380 390 400
ATTTTATVPT TRPVVREPTA LSSSLAPTWL SPTEPATEAP SPPSTAPPTV
410 420 430 440 450
GPVPQPQDCP PSTCLNGGTC HLGTRHHLAC LCPEGFTGLY CESQMGQGTR
460 470 480 490 500
PSPTPVTPRP PRSLTLGIEP VSPTSLRVGL QRYLQGSSVQ LRSLRLTYRN
510 520 530 540 550
LSGPDKRLVT LRLPASLAEY TVTQLRPNAT YSVCVMPLGP GRVPEGEEAC
560 570 580 590 600
GEAHTPPAVH SNHAPVTQAR EGNLPLLIAP ALAAVLLAAL AAVGAAYCVR
610 620 630 640 650
RGRAMAAAAQ DKGQVGPGAG PLELEGVKVP LEPGPKATEG GGEALPSGSE
660 670
CEVPLMGFPG PGLQSPLHAK PYI
Length:673
Mass (Da):71,713
Last modified:August 16, 2004 - v1
Checksum:i891E149652DEA286
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70G → S in AAQ88665 (PubMed:12975309).Curated1
Sequence conflicti91 – 165Missing in AAQ88665 (PubMed:12975309).CuratedAdd BLAST75

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025991384E → A.2 PublicationsCorresponds to variant rs3810818dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY166584 mRNA. Translation: AAO27704.1.
AY358298 mRNA. Translation: AAQ88665.1.
AY358299 mRNA. Translation: AAQ88666.1.
BC013767 mRNA. Translation: AAH13767.1.
BC068575 mRNA. Translation: AAH68575.1.
CCDSiCCDS10514.1.
RefSeqiNP_612449.2. NM_138440.2.
UniGeneiHs.372579.

Genome annotation databases

EnsembliENST00000304735; ENSP00000306864; ENSG00000168140.
ENST00000622615; ENSP00000481884; ENSG00000274334.
GeneIDi114990.
KEGGihsa:114990.
UCSCiuc002cwj.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY166584 mRNA. Translation: AAO27704.1.
AY358298 mRNA. Translation: AAQ88665.1.
AY358299 mRNA. Translation: AAQ88666.1.
BC013767 mRNA. Translation: AAH13767.1.
BC068575 mRNA. Translation: AAH68575.1.
CCDSiCCDS10514.1.
RefSeqiNP_612449.2. NM_138440.2.
UniGeneiHs.372579.

3D structure databases

ProteinModelPortaliQ6EMK4.
SMRiQ6EMK4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125406. 70 interactors.
DIPiDIP-46245N.
IntActiQ6EMK4. 23 interactors.
STRINGi9606.ENSP00000306864.

PTM databases

iPTMnetiQ6EMK4.
PhosphoSitePlusiQ6EMK4.
SwissPalmiQ6EMK4.
UniCarbKBiQ6EMK4.

Polymorphism and mutation databases

BioMutaiVASN.
DMDMi74748436.

Proteomic databases

EPDiQ6EMK4.
MaxQBiQ6EMK4.
PaxDbiQ6EMK4.
PeptideAtlasiQ6EMK4.
PRIDEiQ6EMK4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304735; ENSP00000306864; ENSG00000168140.
ENST00000622615; ENSP00000481884; ENSG00000274334.
GeneIDi114990.
KEGGihsa:114990.
UCSCiuc002cwj.1. human.

Organism-specific databases

CTDi114990.
GeneCardsiVASN.
HGNCiHGNC:18517. VASN.
HPAiHPA011246.
MIMi608843. gene.
neXtProtiNX_Q6EMK4.
OpenTargetsiENSG00000168140.
ENSG00000274334.
PharmGKBiPA134974883.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00730000111167.
HOGENOMiHOG000261606.
HOVERGENiHBG084318.
InParanoidiQ6EMK4.
OMAiDFGCPAT.
OrthoDBiEOG091G04XS.
PhylomeDBiQ6EMK4.
TreeFamiTF351825.

Miscellaneous databases

GenomeRNAii114990.
PROiQ6EMK4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168140.
CleanExiHS_VASN.
GenevisibleiQ6EMK4. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 1 hit.
SM00369. LRR_TYP. 8 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50853. FN3. 1 hit.
PS51450. LRR. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVASN_HUMAN
AccessioniPrimary (citable) accession number: Q6EMK4
Secondary accession number(s): Q6UXL4, Q6UXL5, Q96CX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: August 16, 2004
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.