Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome P450 26B1

Gene

cyp26b1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Appears to be involved in the inactivation of all-trans-retinoic acid (RA). Plays a role in skeletal development.2 Publications

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi440 – 4401Iron (heme axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

  • bone morphogenesis Source: ZFIN
  • cartilage morphogenesis Source: ZFIN
  • coronal suture morphogenesis Source: ZFIN
  • cranial suture morphogenesis Source: ZFIN
  • embryonic cranial skeleton morphogenesis Source: ZFIN
  • head morphogenesis Source: ZFIN
  • hindbrain development Source: ZFIN
  • negative regulation of retinoic acid receptor signaling pathway Source: UniProtKB
  • odontogenesis Source: ZFIN
  • regulation of ossification Source: ZFIN
  • retinoic acid catabolic process Source: ZFIN
  • retinoic acid metabolic process Source: UniProtKB
  • rhombomere 4 morphogenesis Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 26B1 (EC:1.14.-.-)
Short name:
Cyp26B1
Alternative name(s):
Retinoic acid-metabolizing cytochrome
Gene namesi
Name:cyp26b1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-030131-2908. cyp26b1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 511511Cytochrome P450 26B1PRO_0000051986Add
BLAST

Proteomic databases

PaxDbiQ6EIG3.

Expressioni

Developmental stagei

Expressed zygotically. Weak expression at 75% epiboly. At the 2-somite stage, expressed in the presumptive rhombomere 4 (r4) region partially overlapping with the r3 region. At the 10-somite stage, expressed in the r4, r3 and r2 regions. At the 14-somite stage, expression extends to the r5 and r6 regions and is observed in the diencephalon. At 24-48 hours post-fertilization (hpf), additionally expressed in the eye, midbrain-hindbrain boundary, cerebellum, pectoral fin and the pharyngeal arch primordia.1 Publication

Gene expression databases

BgeeiQ6EIG3.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000101543.

Structurei

3D structure databases

ProteinModelPortaliQ6EIG3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Sequence analysis

Phylogenomic databases

eggNOGiKOG0157. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000220829.
HOVERGENiHBG051099.
InParanoidiQ6EIG3.
KOiK12664.
OrthoDBiEOG7F24SP.
PhylomeDBiQ6EIG3.
TreeFamiTF105093.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00465. EP450IV.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6EIG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFESFDLVS ALATLAACLV SMALLLAVPQ QLWQLRWTAT RDKSCKLPMP
60 70 80 90 100
KGSMGFPIIG ETCHWFFQGA GFHASRRQKY GNVFKTHLLG RPLIRVTGAE
110 120 130 140 150
NVRKVLMGEH SLVTVDWPQS TSTLLGPNSL ANSIGDIHRK RRKIFAKVFS
160 170 180 190 200
HEALESYLPK IQQVIQETLR VWSSNPDPIN VYRESQRLSF NMAVRVLLGF
210 220 230 240 250
RIPEEEMHCL FSTFQEFVEN VFSLPIDLPF SGYRKGIRAR DSLQKSIEKA
260 270 280 290 300
IREKPLHTQG KDYTDALDVL LESAKENNTE LTMQELKEST IELIFAAFAT
310 320 330 340 350
TASASTSLVM QLLRHPAVLE KLREELRSCG LLHDGCLCQG ELRLDSIISL
360 370 380 390 400
KYLDCVIKEV LRLFAPVSGG YRIATQTFEL DGVQVPKGWS VMYSIRDTHD
410 420 430 440 450
TSAVFKDVEA FDPDRFSPER SEDREGRFHY LPFGGGVRSC LGKQLATLFL
460 470 480 490 500
KLLAVELAGG SRFELSTRTF PRMISVPVVH PTDGLRVKFF GLDSNQNQIM
510
AKSDEMLDAT V
Length:511
Mass (Da):57,598
Last modified:August 16, 2004 - v1
Checksum:iCBEF6E42745AB381
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291P → S in AAH66759 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY321366 mRNA. Translation: AAQ82596.1.
BC066759 mRNA. Translation: AAH66759.1.
RefSeqiNP_997831.1. NM_212666.1.
UniGeneiDr.76359.

Genome annotation databases

GeneIDi324188.
KEGGidre:324188.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY321366 mRNA. Translation: AAQ82596.1.
BC066759 mRNA. Translation: AAH66759.1.
RefSeqiNP_997831.1. NM_212666.1.
UniGeneiDr.76359.

3D structure databases

ProteinModelPortaliQ6EIG3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000101543.

Proteomic databases

PaxDbiQ6EIG3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi324188.
KEGGidre:324188.

Organism-specific databases

CTDi56603.
ZFINiZDB-GENE-030131-2908. cyp26b1.

Phylogenomic databases

eggNOGiKOG0157. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000220829.
HOVERGENiHBG051099.
InParanoidiQ6EIG3.
KOiK12664.
OrthoDBiEOG7F24SP.
PhylomeDBiQ6EIG3.
TreeFamiTF105093.

Miscellaneous databases

PROiQ6EIG3.

Gene expression databases

BgeeiQ6EIG3.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00465. EP450IV.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of cyp26b1 during zebrafish early development."
    Zhao Q., Dobbs-McAuliffe B., Linney E.
    Gene Expr. Patterns 5:363-369(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: EmbryoImported.
  3. "Craniosynostosis and multiple skeletal anomalies in humans and zebrafish result from a defect in the localized degradation of retinoic acid."
    Laue K., Pogoda H.M., Daniel P.B., van Haeringen A., Alanay Y., von Ameln S., Rachwalski M., Morgan T., Gray M.J., Breuning M.H., Sawyer G.M., Sutherland-Smith A.J., Nikkels P.G., Kubisch C., Bloch W., Wollnik B., Hammerschmidt M., Robertson S.P.
    Am. J. Hum. Genet. 89:595-606(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN SKELETAL DEVELOPMENT.

Entry informationi

Entry nameiCP26B_DANRE
AccessioniPrimary (citable) accession number: Q6EIG3
Secondary accession number(s): Q6NY30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: August 16, 2004
Last modified: June 8, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.