Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6EEV6

- SUMO4_HUMAN

UniProt

Q6EEV6 - SUMO4_HUMAN

Protein

Small ubiquitin-related modifier 4

Gene

SUMO4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I.3 Publications

    GO - Biological processi

    1. protein sumoylation Source: InterPro

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Small ubiquitin-related modifier 4
    Short name:
    SUMO-4
    Alternative name(s):
    Small ubiquitin-like protein 4
    Gene namesi
    Name:SUMO4
    Synonyms:SMT3H4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:21181. SUMO4.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    MIMi600320. phenotype.
    PharmGKBiPA134979206.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9393Small ubiquitin-related modifier 4PRO_0000042710Add
    BLAST
    Propeptidei94 – 952By similarityPRO_0000042711

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki93 – 93Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)

    Post-translational modificationi

    In contrast to SUMO1, SUMO2 and SUMO3, seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates.

    Keywords - PTMi

    Isopeptide bond

    Proteomic databases

    MaxQBiQ6EEV6.
    PaxDbiQ6EEV6.
    PRIDEiQ6EEV6.

    PTM databases

    PhosphoSiteiQ6EEV6.

    Expressioni

    Tissue specificityi

    Expressed mainly in adult and embryonic kidney. Expressed at various levels in immune tissues, with the highest expression in the lymph node and spleen.2 Publications

    Gene expression databases

    BgeeiQ6EEV6.
    CleanExiHS_SUMO4.
    GenevestigatoriQ6EEV6.

    Interactioni

    Subunit structurei

    Interacts with SAE2. Covalently attached to a number of proteins Probable.Curated

    Protein-protein interaction databases

    BioGridi132223. 96 interactions.
    STRINGi9606.ENSP00000318635.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6EEV6.
    SMRiQ6EEV6. Positions 17-88.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini17 – 9579Ubiquitin-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ubiquitin family. SUMO subfamily.Curated
    Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5227.
    HOGENOMiHOG000207495.
    HOVERGENiHBG053025.
    InParanoidiQ6EEV6.
    KOiK12160.
    OrthoDBiEOG76X62R.
    PhylomeDBiQ6EEV6.
    TreeFamiTF315116.

    Family and domain databases

    InterProiIPR022617. Rad60/SUMO_like.
    IPR027218. SUMO_chordates.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PANTHERiPTHR10562:SF10. PTHR10562:SF10. 1 hit.
    PfamiPF11976. Rad60-SLD. 1 hit.
    [Graphical view]
    SMARTiSM00213. UBQ. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.
    PROSITEiPS50053. UBIQUITIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6EEV6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANEKPTEEV KTENNNHINL KVAGQDGSVV QFKIKRQTPL SKLMKAYCEP   50
    RGLSMKQIRF RFGGQPISGT DKPAQLEMED EDTIDVFQQP TGGVY 95
    Length:95
    Mass (Da):10,685
    Last modified:November 8, 2005 - v2
    Checksum:i9012CAEE734ED223
    GO

    Polymorphismi

    Variant Val-55 could be associated with insulin-dependent diabetes mellitus 5 (IDDM5) [MIMi:600320].

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti55 – 551M → V May be associated with susceptibility to type 1 diabetes; greater NFKB1 transcriptional activity and IL12B expression. 6 Publications
    Corresponds to variant rs237025 [ dbSNP | Ensembl ].
    VAR_023740

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY340238 mRNA. Translation: AAR04484.1.
    AB205057 Genomic DNA. Translation: BAH05006.1.
    AL031133 Genomic DNA. Translation: CAA20019.1.
    CH471051 Genomic DNA. Translation: EAW47808.1.
    BC130305 mRNA. Translation: AAI30306.1.
    CCDSiCCDS34549.1.
    RefSeqiNP_001002255.1. NM_001002255.1.
    UniGeneiHs.657168.

    Genome annotation databases

    EnsembliENST00000326669; ENSP00000318635; ENSG00000177688.
    GeneIDi387082.
    KEGGihsa:387082.
    UCSCiuc003qml.3. human.

    Polymorphism databases

    DMDMi81175019.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    SUMO protein entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY340238 mRNA. Translation: AAR04484.1 .
    AB205057 Genomic DNA. Translation: BAH05006.1 .
    AL031133 Genomic DNA. Translation: CAA20019.1 .
    CH471051 Genomic DNA. Translation: EAW47808.1 .
    BC130305 mRNA. Translation: AAI30306.1 .
    CCDSi CCDS34549.1.
    RefSeqi NP_001002255.1. NM_001002255.1.
    UniGenei Hs.657168.

    3D structure databases

    ProteinModelPortali Q6EEV6.
    SMRi Q6EEV6. Positions 17-88.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 132223. 96 interactions.
    STRINGi 9606.ENSP00000318635.

    PTM databases

    PhosphoSitei Q6EEV6.

    Polymorphism databases

    DMDMi 81175019.

    Proteomic databases

    MaxQBi Q6EEV6.
    PaxDbi Q6EEV6.
    PRIDEi Q6EEV6.

    Protocols and materials databases

    DNASUi 387082.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000326669 ; ENSP00000318635 ; ENSG00000177688 .
    GeneIDi 387082.
    KEGGi hsa:387082.
    UCSCi uc003qml.3. human.

    Organism-specific databases

    CTDi 387082.
    GeneCardsi GC06P149763.
    HGNCi HGNC:21181. SUMO4.
    MIMi 600320. phenotype.
    608829. gene.
    neXtProti NX_Q6EEV6.
    PharmGKBi PA134979206.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5227.
    HOGENOMi HOG000207495.
    HOVERGENi HBG053025.
    InParanoidi Q6EEV6.
    KOi K12160.
    OrthoDBi EOG76X62R.
    PhylomeDBi Q6EEV6.
    TreeFami TF315116.

    Miscellaneous databases

    GeneWikii SUMO4.
    GenomeRNAii 387082.
    NextBioi 101180.
    PROi Q6EEV6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6EEV6.
    CleanExi HS_SUMO4.
    Genevestigatori Q6EEV6.

    Family and domain databases

    InterProi IPR022617. Rad60/SUMO_like.
    IPR027218. SUMO_chordates.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    PANTHERi PTHR10562:SF10. PTHR10562:SF10. 1 hit.
    Pfami PF11976. Rad60-SLD. 1 hit.
    [Graphical view ]
    SMARTi SM00213. UBQ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    PROSITEi PS50053. UBIQUITIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus."
      Bohren K.M., Nadkarni V., Song J.H., Gabbay K.H., Owerbach D.
      J. Biol. Chem. 279:27233-27238(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, VARIANT VAL-55, CHARACTERIZATION OF VARIANT VAL-55.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, VARIANT VAL-55, CHARACTERIZATION OF VARIANT VAL-55.
    3. "SUMO4."
      Noso S.
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-55.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-55.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-55.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-55.
    7. "A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation."
      Owerbach D., McKay E.M., Yeh E.T.H., Gabbay K.H., Bohren K.M.
      Biochem. Biophys. Res. Commun. 337:517-520(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: LACK OF PROTEOLYTIC CLEAVAGE.
    8. "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress."
      Guo D., Han J., Adam B.-L., Colburn N.H., Wang M.-H., Dong Z., Eizirik D.L., She J.-X., Wang C.-Y.
      Biochem. Biophys. Res. Commun. 337:1308-1318(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. Cited for: ASSOCIATION OF VARIANT VAL-55 WITH INSULIN-DEPENDENT DIABETES MELLITUS.
    10. "Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes."
      Qu H., Bharaj B., Liu X.Q., Curtis J.A., Newhook L.A., Paterson A.D., Hudson T.J., Polychronakos C.
      Nat. Genet. 37:111-112(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: ASSOCIATION OF VARIANT VAL-55 WITH INSULIN-DEPENDENT DIABETES MELLITUS.
    11. "Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes."
      Park Y., Park S., Kang J., Yang S., Kim D.
      Nat. Genet. 37:112-112(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: ASSOCIATION OF VARIANT VAL-55 WITH INSULIN-DEPENDENT DIABETES MELLITUS.

    Entry informationi

    Entry nameiSUMO4_HUMAN
    AccessioniPrimary (citable) accession number: Q6EEV6
    Secondary accession number(s): A1L3W5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2005
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3