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Protein

DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

Gene

POLR2M

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-31246-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5
Alternative name(s):
DNA-directed RNA polymerase II subunit M, isoforms 4/5
Gene namesi
Name:POLR2M
Synonyms:GRINL1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:14862. POLR2M.

Pathology & Biotechi

Organism-specific databases

DisGeNETi100820829.
145781.
81488.
OpenTargetsiENSG00000255529.
PharmGKBiPA28986.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003262331 – 148DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5Add BLAST148

Proteomic databases

EPDiQ6EEV4.
MaxQBiQ6EEV4.
PeptideAtlasiQ6EEV4.
PRIDEiQ6EEV4.
TopDownProteomicsiQ6EEV4-2. [Q6EEV4-2]

PTM databases

iPTMnetiQ6EEV4.
PhosphoSitePlusiQ6EEV4.

Expressioni

Gene expression databases

CleanExiHS_GRINL1A.
ExpressionAtlasiQ6EEV4. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi123498. 56 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ6EEV4.
SMRiQ6EEV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000063232.

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 4 (identifier: Q6EEV4-1) [UniParc]FASTAAdd to basket
Also known as: Gdown4

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATPARAPES PPSADPALVA GPAEEAECPP PRQPQPAQNV LAAPRLRAPS
60 70 80 90 100
SRGLGAAEFG GAAGNVEAPG ETFAQRVSWG PAESPPGSFS SSSLGAPLPS
110 120 130 140
RTLFPSLEGD FDSVTFASVL RASGRRACCG RAVPLPGQKI HLQIARQR
Length:148
Mass (Da):15,131
Last modified:August 16, 2004 - v1
Checksum:iA820EB7E6488C298
GO
Isoform 1 (identifier: P0CAP2-1) [UniParc]FASTAAdd to basket
Also known as: Gdown1
The sequence of this isoform can be found in the external entry P0CAP2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:368
Mass (Da):41,740
GO
Isoform 2 (identifier: P0CAP2-2) [UniParc]FASTAAdd to basket
Also known as: Gdown6
The sequence of this isoform can be found in the external entry P0CAP2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:211
Mass (Da):24,533
GO
Isoform 3 (identifier: P0CAP2-3) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P0CAP2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:363
Mass (Da):40,734
GO
Isoform 5 (identifier: Q6EEV4-2) [UniParc]FASTAAdd to basket
Also known as: Gdown3

The sequence of this isoform differs from the canonical sequence as follows:
     77-138: Missing.

Show »
Length:86
Mass (Da):8,827
Checksum:iB5EC3D84577E830D
GO
Isoform 6 (identifier: P0CAP1-11) [UniParc]FASTAAdd to basket
Also known as: Gcom1, GRINL1A complex locus protein 1
The sequence of this isoform can be found in the external entry P0CAP1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Based on a naturally occurring readthrough transcript which produces a MYZAP-POLR2M fusion protein.
Length:550
Mass (Da):64,046
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054029127A → P.Corresponds to variant rs11858659dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03262477 – 138Missing in isoform 5. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY341344 mRNA. Translation: AAQ76830.1.
AY339380 mRNA. Translation: AAQ82540.1.
RefSeqiNP_001018112.1. NM_001018102.2.
NP_056347.1. NM_015532.4.
UniGeneiHs.437256.
Hs.702937.

Genome annotation databases

EnsembliENST00000464277; ENSP00000437015; ENSG00000255529. [Q6EEV4-1]
GeneIDi81488.
KEGGihsa:81488.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY341344 mRNA. Translation: AAQ76830.1.
AY339380 mRNA. Translation: AAQ82540.1.
RefSeqiNP_001018112.1. NM_001018102.2.
NP_056347.1. NM_015532.4.
UniGeneiHs.437256.
Hs.702937.

3D structure databases

ProteinModelPortaliQ6EEV4.
SMRiQ6EEV4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123498. 56 interactors.

PTM databases

iPTMnetiQ6EEV4.
PhosphoSitePlusiQ6EEV4.

Proteomic databases

EPDiQ6EEV4.
MaxQBiQ6EEV4.
PeptideAtlasiQ6EEV4.
PRIDEiQ6EEV4.
TopDownProteomicsiQ6EEV4-2. [Q6EEV4-2]

Protocols and materials databases

DNASUi81488.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000464277; ENSP00000437015; ENSG00000255529. [Q6EEV4-1]
GeneIDi81488.
KEGGihsa:81488.

Organism-specific databases

CTDi81488.
DisGeNETi100820829.
145781.
81488.
GeneCardsiPOLR2M.
HGNCiHGNC:14862. POLR2M.
MIMi606485. gene.
neXtProtiNX_Q6EEV4.
OpenTargetsiENSG00000255529.
PharmGKBiPA28986.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000063232.

Enzyme and pathway databases

BioCyciZFISH:G66-31246-MONOMER.

Miscellaneous databases

GenomeRNAii81488.
SOURCEiSearch...

Gene expression databases

CleanExiHS_GRINL1A.
ExpressionAtlasiQ6EEV4. baseline and differential.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiGL1AD_HUMAN
AccessioniPrimary (citable) accession number: Q6EEV4
Secondary accession number(s): Q6EEV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: August 16, 2004
Last modified: November 30, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The adjacent MYZAP and POLR2M genes are part of a complex transcription unit. The respective transcripts derive from different promoters and are alternatively spliced. In human, some transcripts of the upstream promoter of MYZAP use exons of the downstream POLR2M gene.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.