Q6EEV4 (GL1AD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

Alternative name(s):
DNA-directed RNA polymerase II subunit M, isoforms 4/5

Gene names

Name:	POLR2M
Synonyms:	GRINL1A

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	148 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 4 (identifier: Q6EEV4-1)

Also known as: Gdown4;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: P0CAP2-1)

Also known as: Gdown1;

The sequence of this isoform can be found in the external entry P0CAP2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Isoform 2 (identifier: P0CAP2-2)

Also known as: Gdown6;

The sequence of this isoform can be found in the external entry P0CAP2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Isoform 3 (identifier: P0CAP2-3)

The sequence of this isoform can be found in the external entry P0CAP2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Isoform 5 (identifier: Q6EEV4-2)

Also known as: Gdown3;

The sequence of this isoform differs from the canonical sequence as follows:
     77-138: Missing.

Isoform 6 (identifier: P0CAP1-11)

Also known as: Gcom1;

The sequence of this isoform can be found in the external entry P0CAP1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Based on a naturally occurring readthrough transcript which produces a GCOM1-POLR2M fusion protein.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 148	148	DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5		PRO_0000326233
Natural variations
	Alternative sequence	77 – 138	62	Missing in isoform 5.		VSP_032624
	Natural variant	127	1	A → P. Corresponds to variant rs11858659 [ dbSNP | Ensembl ].		VAR_054029

Sequences

	Sequence		Length	Mass (Da)
	Isoform 4 (Gdown4) [UniParc]. Last modified August 16, 2004. Version 1. Checksum: A820EB7E6488C298	FASTA	148	15,131
	10 20 30 40 50 60 MATPARAPES PPSADPALVA GPAEEAECPP PRQPQPAQNV LAAPRLRAPS SRGLGAAEFG 70 80 90 100 110 120 GAAGNVEAPG ETFAQRVSWG PAESPPGSFS SSSLGAPLPS RTLFPSLEGD FDSVTFASVL 130 140 RASGRRACCG RAVPLPGQKI HLQIARQR
	Isoform 1 (Gdown1) [UniParc]. See P0CAP2.		–	–
	Isoform 2 (Gdown6) [UniParc]. See P0CAP2.		–	–
	Isoform 3 [UniParc]. See P0CAP2.		–	–
	Isoform 5 (Gdown3) [UniParc]. Checksum: B5EC3D84577E830D	FASTA	86	8,827
	10 20 30 40 50 60 MATPARAPES PPSADPALVA GPAEEAECPP PRQPQPAQNV LAAPRLRAPS SRGLGAAEFG 70 80 GAAGNVEAPG ETFAQRKIHL QIARQR
	Isoform 6 (Gcom1) [UniParc]. See P0CAP1.		–	–

References

[1]	"The human GRINL1A gene defines a complex transcription unit, an unusual form of gene organization in eukaryotes." Roginski R.S., Mohan Raj B.K., Birditt B., Rowen L. Genomics 84:265-276(2004) [PubMed: 15233991] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4 AND 5). Tissue: Brain and Heart.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY341344 mRNA. Translation: AAQ76830.1. AY339380 mRNA. Translation: AAQ82540.1.
IPI	IPI00455444. IPI00455446.
RefSeq	NP_001018112.1. NM_001018102.1. NP_056347.1. NM_015532.3.
UniGene	Hs.437256.
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q6EEV4.
Proteomic databases
PRIDE	Q6EEV4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	81488.
KEGG	hsa:81488.
UCSC	uc002aev.1. human.
Organism-specific databases
CTD	81488.
GeneCards	GC15P057885.
HGNC	HGNC:14862. POLR2M.
MIM	606485. gene.
neXtProt	NX_Q6EEV4.
GenAtlas	Search...
Gene expression databases
CleanEx	HS_GRINL1A.
Genevestigator	Q6EEV4.
Family and domain databases
ProtoNet	Search...
Other
NextBio	71714.
SOURCE	Search...

Entry information

Entry name

GL1AD_HUMAN

Accession

Primary (citable) accession number: Q6EEV4
Secondary accession number(s): Q6EEV7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	August 16, 2004
Last modified:	January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.