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Protein

Carboxylic ester hydrolase

Gene

estA

Organism
Aspergillus niger
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation

Enzyme and pathway databases

SABIO-RKQ6ED33.

Protein family/group databases

ESTHERiaspni-EstA. Fungal_carboxylesterase_lipase.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxylic ester hydrolaseUniRule annotation (EC:3.1.1.-UniRule annotation)
Gene namesi
Name:estAImported
OrganismiAspergillus nigerImported
Taxonomic identifieri5061 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616UniRule annotationAdd
BLAST
Chaini17 – 538522Carboxylic ester hydrolaseUniRule annotationPRO_5005143954Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi85 ↔ 101Combined sources
Glycosylationi138 – 1381N-linked (GlcNAc...)Combined sourcesCAR_5005389954
Disulfide bondi263 ↔ 272Combined sources
Disulfide bondi402 ↔ 526Combined sources

Proteomic databases

PaxDbiQ6ED33.

Interactioni

Protein-protein interaction databases

STRINGi5061.CADANGAP00010509.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UKCX-ray2.10A/B17-538[»]
ProteinModelPortaliQ6ED33.
SMRiQ6ED33. Positions 22-538.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6ED33.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 529504COesteraseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the type-B carboxylesterase/lipase family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG4389. Eukaryota.
COG2272. LUCA.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ED33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHLVCLALL CHVARGLPTQ ASHNAQPVIN LGYARYQGVR LEAGVDEFLG
60 70 80 90 100
MRYASPPIGD LRFRAPQDPP ANQTLQSATE YGPICIGLDE EESPGDISED
110 120 130 140 150
CLFINVFKPS TATSQSKLPV WLFIQGGGYA ENSNANYNGT QVIQASDDVI
160 170 180 190 200
VFVTFNYRVG ALGFLASEKV RQNGDLNAGL LDQRKALRWV KQYIEQFGGD
210 220 230 240 250
PDHIVIHGVS AGAGSVAYHL SAYGGKDEGL FIGAIVESSF WPTQRTVSEM
260 270 280 290 300
EFQFERFVND TGCSSARDSL ECLREQDIAT IQKGNTGSPF PGGSSSPLPD
310 320 330 340 350
WYFLPVTDGS LVPDELYNAF DAGNFIKVPV LVGDDTDEGS NFAYNASSSA
360 370 380 390 400
DVSRFFKNNY PNLTSQQLNE INQVYPRGKL LPRHAAYFGA SSAAYGDATF
410 420 430 440 450
TCPGNHVASS AARYLPNSVW NYRVNIIDES NIAGGIGVPH TFELPAIFGA
460 470 480 490 500
GSTGTLSSDS SYLTYNAAII PVTMHYFISF VQTLNPNTYR YATAPEWNTW
510 520 530
GNGQRLRLQT NDTAMEAVPE SSLQDCAFWK SLTVPMEV
Length:538
Mass (Da):58,624
Last modified:August 16, 2004 - v1
Checksum:i5A67673A25FED228
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY456379 Genomic DNA. Translation: AAS13488.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY456379 Genomic DNA. Translation: AAS13488.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UKCX-ray2.10A/B17-538[»]
ProteinModelPortaliQ6ED33.
SMRiQ6ED33. Positions 22-538.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5061.CADANGAP00010509.

Protein family/group databases

ESTHERiaspni-EstA. Fungal_carboxylesterase_lipase.

Proteomic databases

PaxDbiQ6ED33.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG4389. Eukaryota.
COG2272. LUCA.

Enzyme and pathway databases

SABIO-RKQ6ED33.

Miscellaneous databases

EvolutionaryTraceiQ6ED33.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Aspergillus niger protein EstA defines a new class of fungal esterases within the alpha/beta hydrolase fold superfamily of proteins."
    Bourne Y., Hasper A.A., Chahinian H., Juin M., De Graaff L.H., Marchot P.
    Structure 12:677-687(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ6ED33_ASPNG
AccessioniPrimary (citable) accession number: Q6ED33
Entry historyi
Integrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: May 11, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.