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Protein

Tachykinin-4

Gene

TAC4

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Tachykinin-4
Alternative name(s):
Preprotachykinin-C
Short name:
PPT-C
Cleaved into the following 2 chains:
Gene namesi
Name:TAC4Imported
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 19

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000032001720 – 55By similarityAdd BLAST36
PeptideiPRO_500009247158 – 67Endokinin-1Imported10
PeptideiPRO_500009247271 – 82Endokinin-2ImportedAdd BLAST12
PropeptideiPRO_000032001885 – 100By similarityAdd BLAST16

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Expressioni

Gene expression databases

BgeeiENSOCUG00000023306.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000019855.

Family & Domainsi

Sequence similaritiesi

Belongs to the tachykinin family.Sequence analysis

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2QI. Eukaryota.
ENOG41113ZV. LUCA.
GeneTreeiENSGT00390000015220.
HOGENOMiHOG000154596.
HOVERGENiHBG097570.
InParanoidiQ6ECK6.
KOiK05241.
OMAiWVTVTLE.
OrthoDBiEOG091G0TYJ.
TreeFamiTF338519.

Family and domain databases

InterProiView protein in InterPro
IPR013055. Tachy_Neuro_lke_CS.
IPR008216. Tachykinin_fam.
PANTHERiPTHR11250. PTHR11250. 1 hit.
PROSITEiView protein in PROSITE
PS00267. TACHYKININ. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ECK6-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSSVTLLLL MGLSVCTSAE DGGEEQTLGA EAGPWVTVTL EAGAVASIQL
60 70 80 90 100
QLQEVKRGKA SQFFGLMGKR VRGYQMGQRG LLGRRASSTK GSVDEDQGAE
Length:100
Mass (Da):10,487
Last modified:August 16, 2004 - v1
Checksum:iA22C9F1D1F456BE7
GO
Isoform 2 (identifier: Q6ECK6-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     74-91: Missing.

Show »
Length:82
Mass (Da):8,539
Checksum:iCD5CB29B9B951B92
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05268274 – 91Missing in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY471576 mRNA. Translation: AAS46598.1.
AY471577 mRNA. Translation: AAS46599.1.
RefSeqiNP_001075634.1. NM_001082165.1. [Q6ECK6-1]
UniGeneiOcu.3179.

Genome annotation databases

EnsembliENSOCUT00000024419; ENSOCUP00000019855; ENSOCUG00000023306. [Q6ECK6-1]
GeneIDi100008925.
KEGGiocu:100008925.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTKN4_RABIT
AccessioniPrimary (citable) accession number: Q6ECK6
Secondary accession number(s): Q6ECK5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: August 16, 2004
Last modified: August 30, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families