ID   ZN470_HUMAN             Reviewed;         717 AA.
AC   Q6ECI4; A8MTW0; B9EGU1; Q6ZPA1; Q9Y2N9;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 3.
DT   27-MAR-2024, entry version 156.
DE   RecName: Full=Zinc finger protein 470;
DE   AltName: Full=Chondrogenesis zinc finger protein 1;
DE            Short=CZF-1;
GN   Name=ZNF470; Synonyms=CZF1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, AND VARIANTS LEU-23 AND ILE-418.
RC   TISSUE=Mesenchymal stem cell;
RX   PubMed=15302581; DOI=10.1016/j.yexcr.2004.05.030;
RA   Hering T.M., Kazmi N.H., Huynh T.D., Kollar J., Xu L., Hunyady A.B.,
RA   Johnstone B.;
RT   "Characterization and chondrocyte differentiation stage-specific expression
RT   of KRAB zinc-finger protein gene ZNF470.";
RL   Exp. Cell Res. 299:137-147(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 188-717 (ISOFORM 1), AND VARIANT
RP   ILE-418.
RC   TISSUE=Adrenal gland;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15302581}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6ECI4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6ECI4-2; Sequence=VSP_023660, VSP_023661;
CC   -!- TISSUE SPECIFICITY: Highly expressed in testis. Very low expression in
CC       thymus. No expression in other tissues tested. Expressed in a
CC       differentiation stage-specific manner in mesenchymal chondrogenic
CC       progenitor cells. {ECO:0000269|PubMed:15302581}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC85218.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY484591; AAS64219.1; -; mRNA.
DR   EMBL; AC007228; AAD23607.1; -; Genomic_DNA.
DR   EMBL; BC136762; AAI36763.1; -; mRNA.
DR   EMBL; AK129686; BAC85218.1; ALT_INIT; mRNA.
DR   CCDS; CCDS33122.1; -. [Q6ECI4-1]
DR   RefSeq; NP_001001668.3; NM_001001668.3. [Q6ECI4-1]
DR   AlphaFoldDB; Q6ECI4; -.
DR   SMR; Q6ECI4; -.
DR   BioGRID; 132748; 2.
DR   STRING; 9606.ENSP00000333223; -.
DR   iPTMnet; Q6ECI4; -.
DR   PhosphoSitePlus; Q6ECI4; -.
DR   BioMuta; ZNF470; -.
DR   DMDM; 313104257; -.
DR   jPOST; Q6ECI4; -.
DR   MassIVE; Q6ECI4; -.
DR   MaxQB; Q6ECI4; -.
DR   PaxDb; 9606-ENSP00000333223; -.
DR   PeptideAtlas; Q6ECI4; -.
DR   ProteomicsDB; 66276; -. [Q6ECI4-1]
DR   ProteomicsDB; 66277; -. [Q6ECI4-2]
DR   Antibodypedia; 33221; 16 antibodies from 11 providers.
DR   DNASU; 388566; -.
DR   Ensembl; ENST00000330619.13; ENSP00000333223.7; ENSG00000197016.12. [Q6ECI4-1]
DR   Ensembl; ENST00000391709.4; ENSP00000375590.3; ENSG00000197016.12. [Q6ECI4-1]
DR   GeneID; 388566; -.
DR   KEGG; hsa:388566; -.
DR   MANE-Select; ENST00000330619.13; ENSP00000333223.7; NM_001001668.4; NP_001001668.3.
DR   UCSC; uc002qnl.5; human. [Q6ECI4-1]
DR   AGR; HGNC:22220; -.
DR   CTD; 388566; -.
DR   GeneCards; ZNF470; -.
DR   HGNC; HGNC:22220; ZNF470.
DR   HPA; ENSG00000197016; Tissue enhanced (retina).
DR   MIM; 620441; gene.
DR   neXtProt; NX_Q6ECI4; -.
DR   OpenTargets; ENSG00000197016; -.
DR   PharmGKB; PA145007252; -.
DR   VEuPathDB; HostDB:ENSG00000197016; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000163087; -.
DR   HOGENOM; CLU_002678_44_5_1; -.
DR   InParanoid; Q6ECI4; -.
DR   OMA; CNDCEKM; -.
DR   OrthoDB; 4760110at2759; -.
DR   PhylomeDB; Q6ECI4; -.
DR   TreeFam; TF341817; -.
DR   PathwayCommons; Q6ECI4; -.
DR   Reactome; R-HSA-212436; Generic Transcription Pathway.
DR   BioGRID-ORCS; 388566; 6 hits in 1170 CRISPR screens.
DR   GenomeRNAi; 388566; -.
DR   Pharos; Q6ECI4; Tdark.
DR   PRO; PR:Q6ECI4; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q6ECI4; Protein.
DR   Bgee; ENSG00000197016; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 108 other cell types or tissues.
DR   ExpressionAtlas; Q6ECI4; baseline and differential.
DR   GO; GO:0016604; C:nuclear body; IDA:HPA.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   Gene3D; 6.10.140.140; -; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 17.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR23232; KRAB DOMAIN C2H2 ZINC FINGER; 1.
DR   PANTHER; PTHR23232:SF90; KRAB DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 16.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 17.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 10.
DR   SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 17.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 17.
DR   Genevisible; Q6ECI4; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..717
FT                   /note="Zinc finger protein 470"
FT                   /id="PRO_0000280413"
FT   DOMAIN          23..94
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         228..250
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         256..278
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         284..306
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         312..334
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         340..362
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         368..391
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         397..419
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         425..447
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         453..475
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         481..503
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         509..531
FT                   /note="C2H2-type 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         537..559
FT                   /note="C2H2-type 12"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         565..587
FT                   /note="C2H2-type 13"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         593..615
FT                   /note="C2H2-type 14"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         621..643
FT                   /note="C2H2-type 15"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         649..671
FT                   /note="C2H2-type 16"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         677..699
FT                   /note="C2H2-type 17"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   MOTIF           216..219
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   MOTIF           385..388
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         63
FT                   /note="G -> GKSIFLLLPPHDSVVFYAIIRISHSFPQHRQFLYVFLHAG (in
FT                   isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_023660"
FT   VAR_SEQ         95..251
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_023661"
FT   VARIANT         23
FT                   /note="V -> L (in dbSNP:rs10421285)"
FT                   /evidence="ECO:0000269|PubMed:15302581"
FT                   /id="VAR_031143"
FT   VARIANT         254
FT                   /note="K -> R (in dbSNP:rs3752179)"
FT                   /id="VAR_031144"
FT   VARIANT         418
FT                   /note="T -> I (in dbSNP:rs4801177)"
FT                   /evidence="ECO:0000269|PubMed:14702039,
FT                   ECO:0000269|PubMed:15302581"
FT                   /id="VAR_031145"
FT   VARIANT         642
FT                   /note="I -> T (in dbSNP:rs35077804)"
FT                   /id="VAR_061950"
FT   CONFLICT        542
FT                   /note="C -> R (in Ref. 1; AAS64219)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        584
FT                   /note="Q -> P (in Ref. 1; AAS64219)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   717 AA;  82650 MW;  3CE8F2E9FC5603A3 CRC64;
     MKSQEEVEVA GIKLCKAMSL GSVTFTDVAI DFSQDEWEWL NLAQRSLYKK VMLENYRNLV
     SVGLCISKPD VISLLEQEKD PWVIKGGMNR GLCPDLECVW VTKSLSLNQD IYEEKLPPAI
     IMERLKSYDL ECSTLGKNWK CEDLFERELV NQKTHFRQET ITHIDTLIEK RDHSNKSGTV
     FHLNTLSYIK QIFPMEERIF NFHTDKKSLK THSVVKKHKQ DRGEKKLLKC NDCEKIFSKI
     STLTLHQRIH TGEKPYECIE CGKAFSQSAH LAQHQRIHTG EKPFECTECG KAFSQNAHLV
     QHQRVHTGEK PYQCKQCNKA FSQLAHLAQH QRVHTGEKPY ECIECGKAFS DCSSLAHHRR
     IHTGKRPYEC IDCGKAFRQN ASLIRHRRYY HTGEKPFDCI DCGKAFTDHI GLIQHKRTHT
     GERPYKCNVC GKAFSHGSSL TVHQRIHTGE KPYECNICEK AFSHRGSLTL HQRVHTGEKP
     YECKECGKAF RQSTHLAHHQ RIHTGEKPYE CKECSKTFSQ NAHLAQHQKI HTGEKPYECK
     ECGKAFSQIA HLVQHQRVHT GEKPYECIEC GKAFSDGSYL VQHQRLHSGK RPYECLECGK
     AFRQRASLIC HQRCHTGEKP YECNVCGKAF SHRKSLTLHQ RIHTGEKPYE CKECSKAFSQ
     VAHLTLHKRI HTGERPYECK ECGKAFRQSV HLAHHQRIHT GESSVILSSA LPYHQVL
//